Ionic liquids as a shuttle for releasing and capturing hydrogen chloride: a new way to utilize waste HCl generated in organic reactions

Abstract

Herein, an ionic liquid, 1-[1-(ethoxycarbonyl)-2-oxopropyl]-3-methylimidazolium chloride (1,3-(CO)2IL-HCl), was synthesized and used as a donor of hydrogen chloride (HCl) to participate into an organic reaction. Interestingly, the simultaneously generated 1-[1-(ethoxycarbonyl)-2-oxopropyl]-3-methylimidazolium inner...

γ-Hydroxy-γ-butyrolactams as 1,2-bis-electrophiles in a Brønsted/Lewis acid-free synthesis of condensed nitrogen heterocycles

“…These factors motivate the pursuit of alternative reagents exhibiting enhanced chemoselectivity, stability, and, consequently, the ability to remain unaltered within the substrate until the required moment without changes. α-Halogen ketones, 14 geminal alcohols 15 and epoxides 16,17 can be used as hidden analogues (Scheme 1b–d, respectively). All the above reagents remain highly reactive and necessitate the use of various catalysts and reagents, including oxidizing agents, which can interact with other functional groups within the molecule.…”