Ionic Liquids and Ohmic Heating in Combination for Pd-Catalyzed Cross-Coupling Reactions: Sustainable Synthesis of Flavonoids

Silva, Vera L. M.; Soengas, Raquel G.; Silva, Artur M. S.

doi:10.3390/molecules25071564

Cited by 13 publications

(6 citation statements)

References 38 publications

(50 reference statements)

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“…There are numerous documented organic reactions carried out under ohmic heating (Soengas et al, 2016). Recently, Silva et al (Silva et al, 2020) have reported a Suzuki-Miyaura reaction protocol that is based on the combined use of ohmic heating (ΩH) and supported ionic liquid phase catalysts. This methodology was applied to obtain different flavonoid derivatives in aqueous media in a sustainable and efficient way.…”

Section: Ohmic and Induction Heatingmentioning

confidence: 99%

Process intensification in continuous flow organic synthesis with enabling and hybrid technologies

et al. 2022

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Industrial organic synthesis is time and energy consuming, and generates substantial waste. Traditional conductive heating and mixing in batch reactors is no longer competitive with continuous-flow synthetic methods and enabling technologies that can strongly promote reaction kinetics. These advances lead to faster and simplified downstream processes with easier workup, purification and process scale-up. In the current Industry 4.0 revolution, new advances that are based on cyber-physical systems and artificial intelligence will be able to optimize and invigorate synthetic processes by connecting cascade reactors with continuous in-line monitoring and even predict solutions in case of unforeseen events. Alternative energy sources, such as dielectric and ohmic heating, ultrasound, hydrodynamic cavitation, reactive extruders and plasma have revolutionized standard procedures. So-called hybrid or hyphenated techniques, where the combination of two different energy sources often generates synergistic effects, are also worthy of mention. Herein, we report our consolidated experience of all of these alternative techniques.

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Section: Ohmic and Induction Heatingmentioning

confidence: 99%

Process intensification in continuous flow organic synthesis with enabling and hybrid technologies

et al. 2022

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“…Silva and co-corkers have recently developed an environmentally benign, economically friendly, and sustainable Suzuki–Miyaura reaction of halo and dihalo dienyl derivatives and boronic acids employing Pd(II) immobilized in a silica-supported ionic liquid in water using ohmic heating (ΩH) [ 74 ]. Ohmic heating is and advanced thermal technology recently developed for organic synthesis [ 75 , 76 ] which leads activation on several reactions, including transition-metal catalysed cross-couplings [ 77 ].…”

Section: Transition Metal-catalysed Cross-coupling Reactionsmentioning

confidence: 99%

Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes

Soengas

Rodríguez‐Solla

2021

Molecules

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The 1,3-butadiene motif is widely found in many natural products and drug candidates with relevant biological activities. Moreover, dienes are important targets for synthetic chemists, due to their ability to give access to a wide range of functional group transformations, including a broad range of C-C bond-forming processes. Therefore, the stereoselective preparation of dienes have attracted much attention over the past decades, and the search for new synthetic protocols continues unabated. The aim of this review is to give an overview of the diverse methodologies that have emerged in the last decade, with a focus on the synthetic processes that meet the requirements of efficiency and sustainability of modern organic chemistry.

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“…These disadvantages can be avoided with modern technologies such as ohmic heating [ 11 ]. The latter is a thermal treatment that heats food by passing an alternating electric current through it; as a consequence, this method has a large capacity for rapid and homogeneous heating [ 12 ]. In addition, this technique provides safe and high-quality food products [ 13 ] while preserving their nutritional value [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Application and Effects of Ohmic-Vacuum Combination Heating on the Quality Factors of Tomato Paste

Alkanan

Altemimi

Al‐Hilphy

et al. 2021

Foods

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Ohmic-vacuum combination heating is a common method used in the food industry as a concentration process. In the present study, an OH-VC combination heating system was developed for producing tomato paste at temperatures of 70, 80, and 90 °C and pressure of 0.3, 0.5, and 0.7 bar and electric field of 1.82, 2.73, and 3.64 V/cm using a central composite design. The effects of heating conditions on the quality and sensory evaluation of tomato paste were also evaluated. Each combination of temperature, pressure, and the electric field was quantified for specific energy consumption, energy efficiency, and productivity. A decrease of 35.08% in the amount of acid ascorbic and lycopene content 19.01%, using conventional heating compared to ohmic-vacuum heating under optimized conditions, was attained. The results also highlighted an increase in the amount of HMF (69.79%) and PME (24.33%) using conventional heating compared to ohmic-vacuum heating under optimized conditions. Ascorbic acid, lycopene, titratable acidity, productivity, energy efficiency was higher than conventional heating; on the other hand, HMF, PME, pH, SEC were lower than conventional heating at the applied OH-VC process. No significant effects between OH-VC and conventional heating on the TSS were observed. In addition, OH-VC heating was highly efficient in the inhibition of bacterial growth. Further, a minor effect on the sensory properties of tomato paste with OH-VC heating compared to the conventional treatment. The obtained results indicate a strong potential for an OH-VC combination heating system as a rapid-heating, high-efficiency alternative for saving electrical energy consumption and preserving nutritional value.

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Ionic Liquids and Ohmic Heating in Combination for Pd-Catalyzed Cross-Coupling Reactions: Sustainable Synthesis of Flavonoids

Cited by 13 publications

References 38 publications

Process intensification in continuous flow organic synthesis with enabling and hybrid technologies

Process intensification in continuous flow organic synthesis with enabling and hybrid technologies

Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes

Application and Effects of Ohmic-Vacuum Combination Heating on the Quality Factors of Tomato Paste

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