Ionic liquid supported multistep divergent synthesis of benzimidazole linked pyrrolo-/pyrido-/isoindolo-benzimidazolones

Polymer-Supported Stereoselective Synthesis of Benzimidazolinopiperazinones

“…3,4,4a,5-Tetrahydrobenzo [4,5]imidazo [1,2-a]pyridin-1(2H)-ones linked by benzimidazoles have also been documented. 16 The aromatic part of 1,2-dihydrobenzo [4,5]imidazo [1,2-a]pyrazin-3(4H)-ones II, benzimidazoles, were synthesized several times, in solution 17−21 and on solid phase. 22−25 Benzimidazole derivatives can serve as angiotensin II receptor antagonists, 26 as inhibitors of trypsinlike serine protease (factor Xa), 27 and as antibacterial agents.…”

“…Other related derivatives, such as deazaanalogues of compound II , 1,2-dihydrobenzo[4,5]imidazo[1,2- a ]pyridin-3(5 H )-ones III (Figure ), are reportedly anxiolytic, − antiviral, and antimicrobial agents. 3,4,4a,5-Tetrahydro­benzo[4,5]imidazo[1,2- a ]pyridin-1(2 H )-ones linked by benzimidazoles have also been documented . The aromatic part of 1,2-dihydrobenzo[4,5]imidazo[1,2- a ]pyrazin-3(4 H )-ones II , benzimidazoles, were synthesized several times, in solution − and on solid phase. − Benzimidazole derivatives can serve as angiotensin II receptor antagonists, as inhibitors of trypsin-like serine protease (factor Xa), and as antibacterial agents .…”

“…The aromatic part of 1,2-dihydrobenzo[4,5]imidazo[1,2- a ]pyrazin-3(4 H )-ones II , benzimidazoles, were synthesized several times, in solution − and on solid phase. − Benzimidazole derivatives can serve as angiotensin II receptor antagonists, as inhibitors of trypsin-like serine protease (factor Xa), and as antibacterial agents . The synthesis of benzimidazolines and their closely related compounds, 2-oxo/thioderivatives and spiro-benzimidazolines, has also been described. ,− …”

Heterocycles-Based Ionic Liquid-Supported Synthesis of Small Organic Molecules

“…IL-grafted 101 was selected as a common scaffold to the synthesis of 2-alkyl-substituted bis-benzimidazole 102, and pyrrole[1,2-a]benzimidazolones 103 using various keto acids in one step (Scheme 12) [43]. SCHEME 12 Sun's diversity-oriented approaches toward heterocycles-resembling compound libraries.…”

Novel dibenzo-18-crown-6 ether functionalized bis-benzimidazole derivatives: synthesis and antifungal evaluation

“…Benzimidazole heterocycles are well established as ''privileged scaffolds,'' being integrated into pharmaceutical agents to form enzyme inhibitors, receptor-binding drugs, and DNA intercalators [13,14]. Benzimidazole derivatives have been reported to possess noteworthy pharmacological activities such as anticancer [15], antimicrobial [16], antihypertensive [17], cytotoxic [18], anticonvulsant [19], antileukemic [20], and antifungal properties [21]. Recently, benzimidazole nucleuscontaining drugs cambendazole, thiabendazole, and mebendazole were reported to display antihelminthics activity [22] (Fig.…”