Ionic liquid-modified silica gel as adsorbents for adsorption and separation of water-soluble phenolic acids from Salvia militiorrhiza Bunge

Nie, Lei; Lü, Jing; Zhang, Wei; He, Aiyong; Yao, Shun

doi:10.1016/j.seppur.2015.01.037

Cited by 40 publications

(23 citation statements)

References 30 publications

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“…The peak at 562 cm −1 for RGO/Fe 3 O 4 corresponds to the stretching vibration of Fe–O of Fe 3 O 4 [33]. While comparing the spectra of RGO/Fe 3 O 4 -IL-MIP before extracting the template molecule with RGO/Fe 3 O 4 , peaks at 1164 and 837 cm −1 were observed, corresponding to the imidazolium cation vibration of the C–N bond and the P–F of PF 6 − stretching vibration [34], respectively. The results suggest the functionalization of PF 6 − based imidazolium ILs onto RGO/Fe 3 O 4 .…”

Section: Resultsmentioning

confidence: 99%

An Electrochemical Sensor for Diphenylamine Detection Based on Reduced Graphene Oxide/Fe3O4-Molecularly Imprinted Polymer with 1,4-Butanediyl-3,3′-bis-l-vinylimidazolium Dihexafluorophosphate Ionic Liquid as Cross-Linker

et al. 2018

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In this paper, we report a new composite of reduced graphene oxide/Fe3O4-ionic liquid based molecularly imprinted polymer (RGO/Fe3O4-IL-MIP) fabricated for diphenylamine (DPA) detection. RGO/Fe3O4-IL-MIP was prepared with RGO/Fe3O4 as supporter, ionic liquid 1-vinyl-3-butylimidazolium hexafluorophosphate ([VC4mim][PF6]) as functional monomer, ionic liquid 1,4-butanediyl-3,3’-bis-l-vinylimidazolium dihexafluorophosphate ([V2C4(mim)2][(PF6)2]) as cross-linker, and diphenylamine (DPA) as template molecule. Fourier transform infrared spectroscopy, thermal gravimetric analysis, scanning electron microscopy, and vibrating sample magnetometer were employed to characterize the RGO/Fe3O4-IL-MIP composite. RGO/Fe3O4-IL-MIP was then drop-cast onto a glassy carbon electrode to construct an electrochemical sensor for DPA. The differential pulse voltammetry (DPV) peak current response for 20 μM DPA of RGO/Fe3O4-IL-MIP modified glassy carbon electrode (GCE) was 3.24 and 1.68 times that of RGO/Fe3O4-IL-NIP and RGO/Fe3O4-EGDMA-MIP modified GCEs, respectively, indicating the advantage of RGO/Fe3O4-IL-MIP based on ionic liquid (IL) as a cross-linker. The RGO/Fe3O4-IL-MIP sensor demonstrated good recognition for DPA. Under the optimized conditions, the RGO/Fe3O4-IL-MIP sensor exhibited a DPA detection limit of 0.05 μM (S/N = 3) with a linear range of 0.1–30 μM. Moreover, the new RGO/Fe3O4-IL-MIP based sensor detected DPA in real samples with satisfactory results.

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Section: Resultsmentioning

confidence: 99%

An Electrochemical Sensor for Diphenylamine Detection Based on Reduced Graphene Oxide/Fe3O4-Molecularly Imprinted Polymer with 1,4-Butanediyl-3,3′-bis-l-vinylimidazolium Dihexafluorophosphate Ionic Liquid as Cross-Linker

et al. 2018

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“…[40]. More recently, Nie et al have applied ionic liquid-modified silica to the isolation of five phenolic acids from Danshen [41]. They further found that silica modified with N -methylimidazolium hexafluorophosphate had the most excellent adsorption capacity for target compounds.…”

Section: Chemical Compoundsmentioning

confidence: 99%

Chemical Analysis of the Herbal Medicine Salviae miltiorrhizae Radix et Rhizoma (Danshen)

Pang

Tang

et al. 2016

Molecules

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Radix Salviae miltiorrhizae et Rhizoma, known as Danshen in China, is one of the most popular traditional Chinese medicines. Recently, there has been increasing scientific attention on Danshen for its remarkable bioactivities, such as promoting blood circulation, removing blood stasis, and clearing away heat. This review summarized the advances in chemical analysis of Danshen and its preparations since 2009. Representative established methods were reviewed, including spectroscopy, thin layer chromatography, gas chromatography, liquid chromatography (LC), liquid chromatography-mass spectrometry (LC-MS), capillary electrophoresis, electrochemistry, and bioanalysis. Especially the analysis of polysaccharides in Danshen was discussed for the first time. Some proposals were also put forward to benefit quality control of Danshen.

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“…There are many publications on the purification of SAB from Danshen, with different technologies of liquid–liquid extraction [9], high-speed countercurrent chromatography [10,11,12,13], and resin chromatography [14,15,16]. Nie et al [17] used ionic liquid-modified silica gel for the separation of water-soluble phenolic acids, including SAB. Guo et al [18] reported a two-step procedure for the large-scale purification of SAB using an aqueous two-phase extraction followed by preparative high-performance liquid chromatography (HPLC).…”

Section: Introductionmentioning

confidence: 99%

Preparation of Salvianolic Acid B Disodium Salt Considering the Water Extract Quality Standard

Gong

2019

Molecules

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A preparation process of salvianolic acid B (SAB) disodium salt from Salvia miltiorrhiza Bunge (Danshen) is provided in this work. A water extract quality standard was also developed to estimate the influences of Danshen quality on SAB disodium salt quality at an early stage of the preparation process. Crude SAB solution was obtained after water extraction, concentration, acidification, 1-butanol extraction, water washing, basification, and water back extraction. Extraction temperature, extraction pH, and back-extraction pH were identified to be key parameters for the preparation of crude SAB solution. These parameters were optimized with Box–Behnken designed experiments. Crude SAB solution was further purified with a chromatography process. AMBERCHROW CG161M resin was selected as the best adsorbent. SAB disodium salt could be obtained by drying the eluate. Considering the quality of Danshen may affect the purity and yield of SAB disodium salt, different batches of Danshen were used to prepare SAB disodium salt with the optimized parameters. Water extract indices of phenolic compound purity and phenolic compound yield were measured. By developing models between SAB disodium salt purity and yield with water extract indices, the quality standard of Danshen water extract was obtained. The application of water extract quality standards can improve the quality consistency of SAB disodium salt. The effects of different batches of Danshen raw materials on the final product could be evaluated at the beginning of production stages. The present method could prepare about five grams of high-purity SAB disodium salt (>95%) in one preparation cycle. The method reported in this work can also be used to develop process intermediate quality standards for other natural products.

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Ionic liquid-modified silica gel as adsorbents for adsorption and separation of water-soluble phenolic acids from Salvia militiorrhiza Bunge

Cited by 40 publications

References 30 publications

An Electrochemical Sensor for Diphenylamine Detection Based on Reduced Graphene Oxide/Fe3O4-Molecularly Imprinted Polymer with 1,4-Butanediyl-3,3′-bis-l-vinylimidazolium Dihexafluorophosphate Ionic Liquid as Cross-Linker

An Electrochemical Sensor for Diphenylamine Detection Based on Reduced Graphene Oxide/Fe3O4-Molecularly Imprinted Polymer with 1,4-Butanediyl-3,3′-bis-l-vinylimidazolium Dihexafluorophosphate Ionic Liquid as Cross-Linker

Chemical Analysis of the Herbal Medicine Salviae miltiorrhizae Radix et Rhizoma (Danshen)

Preparation of Salvianolic Acid B Disodium Salt Considering the Water Extract Quality Standard

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