Ionic liquid/HCl catalyzed synthesis of 4-(trifluoromethyl)-2(1H)-pyrimidinones

Frizzo, Clarissa P.; Marzari, Mara R. B.; Bender, Caroline R.; Gindri, Izabelle M.; Trindade, Jefferson; Buriol, Lilian; Caleffi, Guilherme S.; Bonacorso, Hélio G.; Zanata, Nilo; Martins, Marcos A. P.

doi:10.1007/s00706-013-1126-0

Cited by 3 publications

(2 citation statements)

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“…1 Even though they were described almost a century ago, ILs have recently attracted interest in an assorted array of applications, ranging from synthetic processes in chemistry, [2][3][4] to a number of biological processes, 5 and utilization as active pharmaceutical ingredients (API). 1 Even though they were described almost a century ago, ILs have recently attracted interest in an assorted array of applications, ranging from synthetic processes in chemistry, [2][3][4] to a number of biological processes, 5 and utilization as active pharmaceutical ingredients (API).…”

Section: Introductionmentioning

confidence: 99%

“…Ionic liquids (ILs) are a class of low temperature molten salts, comprised of an amphiphilic cationic moiety and a weakly coordinated anion. 1 Even though they were described almost a century ago, ILs have recently attracted interest in an assorted array of applications, ranging from synthetic processes in chemistry, [2][3][4] to a number of biological processes, 5 and utilization as active pharmaceutical ingredients (API). 6 The most attractive property of ILs is the exibility or 'tunability' in the design of physical, chemical and biological properties by changing the structure of the cation and anion.…”

Section: Introductionmentioning

confidence: 99%

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Dicationic imidazolium-based ionic liquids: a new strategy for non-toxic and antimicrobial materials

et al. 2014

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New dicationic imidazolium-based ionic liquids (ILs) were synthesized, characterized and tested in regards to cytotoxicity and antimicrobial activity. Insertion of a new cationic head and use of organic anions increased the biocompatibility of the ILs developed. IC 50 (concentration necessary to inhibit 50% of enzymatic activity) values obtained were considerably higher than those described for monocationic ILs, which indicates an improvement in cytocompatibility. Antimicrobial activity against bacterial species of clinical relevance in wounds and the oral environment was tested. The results showed that ILs were effective in inhibiting bacterial growth even below the minimum inhibitory concentration (MIC). It was observed that structural features that confer higher hydrophobicity to ILs decreased both the IC 50 and MIC simultaneously. However, it was possible to establish an equilibrium between those two effects, which gives the safe range of concentrations that ILs can be employed. The results demonstrated that the dicationic-imidazolium-based ILs synthesized may constitute a potent strategy for applications requiring non-toxic materials exhibiting antimicrobial activity.

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