Ionic liquid gels and antioxidant carbon nanotubes: Hybrid soft materials with improved radical scavenging activity

Rizzo, Carla; Marullo, Salvatore; Dintcheva, Nadka Tzankova; Gambarotti, Cristian; Billeci, Floriana; D’Anna, Francesca

doi:10.1016/j.jcis.2019.08.108

Cited by 11 publications

(14 citation statements)

References 80 publications

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“…Overall, the temperature induced transition in the ionogel matrix open up new avenues in the field of new age hybrid pharmaceutically active smart materials in the field of biomedical research. [77] The surfactant active properties of these gelators further helps in developing the future technological development of drug formulations. [38]…”

Section: Resultsmentioning

confidence: 99%

Temperature‐Responsive Low Molecular Weight Ionic Liquid Based Gelator: An Approach to Fabricate an Anti‐Cancer Drug‐Loaded Hybrid Ionogel

et al. 2020

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Conceptualising gelators with stimuli responsiveness is advantageous to design smart materials for emerging technologies. These gelators, if are surface active and made up of active pharmaceutical ingredients, can (i) exhibit an interesting pharmaceutical profile, (ii) be useful in drug formulations and (iii) exert direct effects on cell membranes. Herein, cetylpyridinium salicylate (CetPySal) that offers higher surface activity than its precursor surfactant, cetpylpyridinium chloride (CPCl), was synthesised. CetPySal forms a temperature‐responsive ionogel at a critical gelation concentration that changes its physical appearance with temperature, i. e. opaque to transparent, owing to its structural arrangement within its supramolecular framework, that are characterized through spectrometric, calorimetric, scattering and microscopic techniques. The viscoelastic nature of the ionogels was studied through dynamic rheological measurements and the interactions that governs the phase transition were studied through FTIR spectroscopy. The hybrid pharmaceutical ionogels was successfully constructed through encapsulation of the chemotherapeutic drug imatinib mesylate within the ionogel matrix. The sustained release of the drug was investigated from this hybrid ionogel matrix. These results suggest that this new thermo‐responsive ionogel may be used to improve sustained release of drugs and open up new avenues as low‐cost gelators for biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Temperature‐Responsive Low Molecular Weight Ionic Liquid Based Gelator: An Approach to Fabricate an Anti‐Cancer Drug‐Loaded Hybrid Ionogel

et al. 2020

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“…The electrostatic repulsive forces induced from the oxygen-containing groups and the hydrophobic interaction between NFC and MWCNTs facilitate the dispersion of MWCNTs in NFC suspension [ 33 ], which is consistent with the result of SEM analysis. MWCNTs with oxygen-containing groups can be also seen as the functionalized CNTs, which can favor the dispersion, assembly and reinforcement in the substrate [ 60 ].…”

Section: Resultsmentioning

confidence: 99%

A Nanofibrillated Cellulose-Based Electrothermal Aerogel Constructed with Carbon Nanotubes and Graphene

Zhuo¹,

Cao²,

Li³

et al. 2020

Molecules

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Nanofibrillated cellulose (NFC) as an environmentally friendly substrate material has superiority for flexible electrothermal composite, while there is currently no research on porous NFC based electrothermal aerogel. Therefore, this work used NFC as a skeleton, combined with multi-walled carbon nanotubes (MWCNTs) and graphene (GP), to prepare NFC/MWCNTs/GP aerogel (CCGA) via a simple and economic freeze-drying method. The electrothermal CCGA was finally assembled after connecting CCGA with electrodes. The results show that when the concentration of the NFC/MWCNTs/GP suspension was 5 mg mL−1 and NFC amount was 80 wt.%, the maximum steady-state temperature rise of electrothermal CCGA at 3000 W m−2 and 2000 W m−2 was of about 62.0 °C and 40.4 °C, respectively. The resistance change rate of the CCGA was nearly 15% at the concentration of 7 mg mL−1 under the power density of 2000 W m−2. The formed three-dimensional porous structure is conducive to the heat exchange. Consequently, the electrothermal CCGA can be used as a potential lightweight substrate for efficient electrothermal devices.

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“…[ 81 ] Polymeric gel or film endowing antioxidant properties are other meaningful applications of Vit E for macroscale materials. [ 82 ] For instance, enhancing the shelf life of food products by introducing Vit E and other antioxidants is well described in a review by Jafari. [ 83 ] In the case of biomedical applications, most strategies exploit conventional polymer‐based delivery systems, such as polymeric micelles or NPs, because of the hydrophobicity of Vit E. At the early stage, Vit E was simply loaded in the polymer‐based depot and sustained release was observed.…”

Section: Polymer‐based Delivery Of Antioxidantsmentioning

confidence: 99%

Polymeric Antioxidant Materials for Treatment of Inflammatory Disorders

Yeo

Lee

et al. 2021

Advanced Therapeutics

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Reactive oxygen and nitrogen species (RONS) play a key role in physiological conditions as signaling molecules for regulating homeostasis in the human body. However, abnormally increased RONS levels can damage DNA, protein, and tissue, or even impair cellular signaling. Consequently, when this state is present for a long time, it can lead to severe inflammatory disorders, such as lupus, diabetes, rheumatoid arthritis, Crohn's disease, and neurodegenerative disorders. Although antioxidant therapies have been developed for a long time to treat acute or chronic inflammatory diseases, small molecule‐based antioxidants showed relatively low therapeutic effects due to rapid clearance and low stability in the bloodstream. As one of the solutions to overcome such limitations, incorporating polymers would provide enhanced blood stability, bioavailability, and even enhanced therapeutic effects. Herein, diverse polymeric antioxidant materials are introduced that are categorized into simple loading strategies and polymers with inherent antioxidative activity. Further, preclinical and clinical studies of polymeric antioxidant materials for anti‐inflammatory therapy are discussed and a better direction is provided for these to be pursued and improved in anti‐inflammatory therapy.

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Ionic liquid gels and antioxidant carbon nanotubes: Hybrid soft materials with improved radical scavenging activity

Cited by 11 publications

References 80 publications

Temperature‐Responsive Low Molecular Weight Ionic Liquid Based Gelator: An Approach to Fabricate an Anti‐Cancer Drug‐Loaded Hybrid Ionogel

Temperature‐Responsive Low Molecular Weight Ionic Liquid Based Gelator: An Approach to Fabricate an Anti‐Cancer Drug‐Loaded Hybrid Ionogel

A Nanofibrillated Cellulose-Based Electrothermal Aerogel Constructed with Carbon Nanotubes and Graphene

Polymeric Antioxidant Materials for Treatment of Inflammatory Disorders

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