Ionic Liquid-Functionalized Titanomagnetite Nanoparticles as Efficient and Recyclable Catalyst for Green Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

Abstract

In the present study, titanomagnetite nanoparticles (Fe 3-x Ti x O 4 NPs) were synthesized via coprecipitation approach and then functionalized using 3trimethoxysilylpropyl chloride silan coupling agent followed by tetrabutylammonium asparaginate through a facial and newly one-pot procedure to afford an ionic liquid (IL)-modified Fe 3-x Ti x O 4 NPs. The synthesized NPs were examined as potent and recyclable nanocatalysts for one-pot three-component synthesis of 2,3-dihydroquinazolin-4(1H)-ones under solvent-free conditions. Easy magnetic separation and efficient recyclability of the catalyst, excellent yields of the reactions, low reaction times as well as solvent-free conditions are the most important advantages of the present procedure that qualified the fabricated Fe 3-x Ti x O 4 NPs as a nanocatalyst for industrial applications.

Cascade embedding triethyltryptophanium iodide ionic liquid (TrpEt3+I−) on silicated titanomagnetite core (Fe3‐xTixO4‐SiO2@TrpEt3+I−): A novel nano organic–inorganic hybrid to prepare a library of 4‐substituted quinoline‐2‐carboxylates and 4,6‐disubstituted quinoline‐2‐carboxylates

“…[32] In addition, many catalytic systems were prepared based on titanomagnetite to promote different kinds of organic transformations like synthesis of dihydropyrano[3,2-c]chromen-2-ones, [33] tetrahydrobenzo [b]pyrans, and dihydropyrano [2,3-c]pyrazoles synthesis, [34] hexahydroquinolines, [35,36] and 2,3-dihydroquinazolin-4 (1H)-ones. [37] Ionic liquids (ILs) are organic/inorganic salts with a melting point often below 100 C, low vapor pressure, low toxicity, high ion density and ionic conductivity, high chemical stabilities, and nonflammability. ILs possess wide-spread availability through changeable cations and anions that play dual crucial role in organic chemistry as exclusive catalyst/reaction media.…”

“…[ 32 ] In addition, many catalytic systems were prepared based on titanomagnetite to promote different kinds of organic transformations like synthesis of dihydropyrano[3,2‐c]chromen‐2‐ones, [ 33 ] tetrahydrobenzo[ b ]pyrans, and dihydropyrano[2,3‐ c ]pyrazoles synthesis, [ 34 ] hexahydroquinolines, [ 35,36 ] and 2,3‐dihydroquinazolin‐4(1 H )‐ones. [ 37 ]…”