Ionic liquid functionalized non-releasing antibacterial hydrogel dressing coupled with electrical stimulation for the promotion of diabetic wound healing

Liu, Pan; Jin, Kai; Wong, Wing‐Leung; Wang, Yanying; Liang, Tao; He, Meng; Li, Huiyue; Lu, Chunfeng; Tang, Xue; Zong, Yuange; Li, Chunya

doi:10.1016/j.cej.2021.129025

Cited by 96 publications

(44 citation statements)

References 66 publications

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“…Zinc ion-coordinated poly-IL membranes with bactericidal properties were efficiently used for wound healing [184]. A conductive hydrogel wound dressing composed of a poly-IL (1-vinyl-3-(aminopropyl)imidazolium tetrafluoroborate) and konjac glucomannan demonstrated long-lasting bactericidal activity against S. aureus and E. coli [185]. Similarly, promising results were obtained with a poly-IL (1-vinyl-3-butylimidazolium bromide)/poly(vinyl alcohol) wound dressing [172], a reusable 1-vinyl-3-butylimidazolium bromide-grafted cotton gauze wound dressing [173], and molecular brushes with 3-(12-mercaptododecyl)-1methylimidazolium bromide [186].…”

Section: Ionic Liquid-containing Bactericidal Coatingsmentioning

confidence: 99%

Quaternary Ammonium Compounds (QACs) and Ionic Liquids (ILs) as Biocides: From Simple Antiseptics to Tunable Antimicrobials

Vereshchagin

Frolov

Egorova

et al. 2021

IJMS

156

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Quaternary ammonium compounds (QACs) belong to a well-known class of cationic biocides with a broad spectrum of antimicrobial activity. They are used as essential components in surfactants, personal hygiene products, cosmetics, softeners, dyes, biological dyes, antiseptics, and disinfectants. Simple but varied in their structure, QACs are divided into several subclasses: Mono-, bis-, multi-, and poly-derivatives. Since the beginning of the 20th century, a significant amount of work has been dedicated to the advancement of this class of biocides. Thus, more than 700 articles on QACs were published only in 2020, according to the modern literature. The structural variability and diverse biological activity of ionic liquids (ILs) make them highly prospective for developing new types of biocides. QACs and ILs bear a common key element in the molecular structure–quaternary positively charged nitrogen atoms within a cyclic or acyclic structural framework. The state-of-the-art research level and paramount demand in modern society recall the rapid development of a new generation of tunable antimicrobials. This review focuses on the main QACs exhibiting antimicrobial and antifungal properties, commercial products based on QACs, and the latest discoveries in QACs and ILs connected with biocide development.

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Section: Ionic Liquid-containing Bactericidal Coatingsmentioning

confidence: 99%

Quaternary Ammonium Compounds (QACs) and Ionic Liquids (ILs) as Biocides: From Simple Antiseptics to Tunable Antimicrobials

Vereshchagin

Frolov

Egorova

et al. 2021

IJMS

156

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“…Ionic liquids are a group of organic salts comprised of organic cations and organic or inorganic anions [ 28 , 29 ]. They are chemical and thermally stable, biocompatible, and antibacterial and can maintain fluidity at or near room temperature [ 30 – 32 ]. By composing the ionic liquids into hydrogels (ionic gel), the low saturated vapor pressure and high ionic conductivity of ionic liquids would endow the hydrogel with a highly sensitive perception at a wide temperature range [ 30 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

“…They are chemical and thermally stable, biocompatible, and antibacterial and can maintain fluidity at or near room temperature [ 30 – 32 ]. By composing the ionic liquids into hydrogels (ionic gel), the low saturated vapor pressure and high ionic conductivity of ionic liquids would endow the hydrogel with a highly sensitive perception at a wide temperature range [ 30 , 33 , 34 ]. Moreover, since the numbers of the migratable ions and the ion migration rate vary with the temperature, the ionic gel displays a distinct thermal-sensitive feature, being feasible for multimodal signal sensation [ 29 , 30 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Lignin-Reinforced Poly(Ionic Liquid) Hydrogel Wireless Strain Sensor

Zhao

Chen

et al. 2021

Research

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To meet critical requirements on flexible electronic devices, multifunctionalized flexible sensors with excellent electromechanical performance and temperature perception are required. Herein, lignin-reinforced thermoresponsive poly(ionic liquid) hydrogel is prepared through an ultrasound-assisted synthesized method. Benefitting from the electrostatic interaction between lignin and ionic liquid, the hydrogel displays high stretchability (over 1425%), excellent toughness (over 132 kPa), and impressive stress loading-unloading cyclic stability. The hydrogel strain sensor presents excellent electromechanical performance with a high gauge factor (1.37) and rapid response rate (198 ms), which lays the foundation for human body movement detection and smart input. Moreover, owing to the thermal-sensitive feature of poly(ionic liquid), the as-prepared hydrogel displays remarkable thermal response sensitivity (0.217°C-1) in body temperature range and low limit of detection, which can be applied as a body shell temperature indicator. Particularly, the hydrogel can detect dual stimuli of strain and temperature and identify each signal individually, showing the specific application in human-machine interaction and artificial intelligence. By integrating the hydrogel strain sensor into a wireless sensation system, remote motion capture and gesture identification is realized in real-time.

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“…Hydrogels are cross-linked three-dimensional networks comprised of hydrophilic polymer chains, which can absorb and retain large amounts of water or biological fluids [ 8 , 9 ]. Hydrogels, with large water uptake ability, have a microenvironment similar to the natural structure.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing

Zhang

Xiao-rui

et al. 2021

Marine Drugs

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Hydrogels, possessing high biocompatibility and adaptability to biological tissue, show great usability in medical applications. In this research, a series of novel cross-linked chitosan quaternary ammonium salt loading with gentamicin sulfate (CTMCSG) hydrogel films with different cross-linking degrees were successfully obtained by the reaction of chitosan quaternary ammonium salt (TMCS) and epichlorohydrin. Fourier transform infrared spectroscopy (FTIR), thermal analysis, and scanning electron microscope (SEM) were used to characterize the chemical structure and surface morphology of CTMCSG hydrogel films. The physicochemical property, gentamicin sulphate release behavior, cytotoxicity, and antibacterial activity of the CTMCSG against Escherichia coli and Staphylococcus aureus were determined. Experimental results demonstrated that CTMCSG hydrogel films exhibited good water stability, thermal stability, drug release capacity, as well as antibacterial property. The inhibition zone of CTMCSG hydrogel films against Escherichia coli and Staphylococcus aureus could be up to about 30 mm. Specifically, the increases in maximum decomposition temperature, mechanical property, water content, swelling degree, and a reduction in water vapor permeability of the hydrogel films were observed as the amount of the cross-linking agent increased. The results indicated that the CTMCSG-4 hydrogel film with an interesting physicochemical property, admirable antibacterial activity, and slight cytotoxicity showed the potential value as excellent antibacterial wound dressing.

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Ionic liquid functionalized non-releasing antibacterial hydrogel dressing coupled with electrical stimulation for the promotion of diabetic wound healing

Cited by 96 publications

References 66 publications

Quaternary Ammonium Compounds (QACs) and Ionic Liquids (ILs) as Biocides: From Simple Antiseptics to Tunable Antimicrobials

Quaternary Ammonium Compounds (QACs) and Ionic Liquids (ILs) as Biocides: From Simple Antiseptics to Tunable Antimicrobials

Thermoresponsive Lignin-Reinforced Poly(Ionic Liquid) Hydrogel Wireless Strain Sensor

Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing

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