Ionic liquid‐based ultrasound‐assisted extraction of fangchinoline and tetrandrine from Stephaniae tetrandrae

Abstract

An ionic liquid-based ultrasound-assisted extraction method has been developed for the effective extraction of fangchinoline and tetrandrine from Stephaniae tetrandrae. The effects of some ultrasound-assisted extraction parameters including the concentration of [BMIM][BF(4)], pH, ultrasonic power and time were investigated to optimize the ultrasound-assisted extraction conditions. Compared to the regular ultrasound-assisted extraction and traditional refluent extraction, the proposed [BMIM][BF(4)]-based ultrasound-assisted extraction offered shorter extraction times (from 6 h to 40 min) and remarkable higher efficiencies (approximately 30% improved), which supported the suitability of the proposed approach. In addition, the proposed approach was confirmed by the good correlation coefficient (R(2)), recovery and reproducibility (RSD, n = 5), which were in the range of 0.9992-0.9995, 85.5-101.1%, and 1.87-4.33%, respectively.

Application of ionic liquid for extraction and separation of bioactive compounds from plants

“…Traditional refluent solvent extraction has been used to extract fangchinoline and tetrandrine from S. tetrandrae. Compared to traditional refluent solvent extraction, Zhang et al developed an IL-based ultrasound-assisted extraction technique for the effective extraction of fangchinoline and tetrandrine from S. tetrandrae [61]. The effects of some ultrasound-assisted extraction parameters including the concentration of 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF 4 ]), pH, ultrasonic power and time were examined to optimize the ultrasound-assisted extraction conditions.…”

Optimization of ionic liquid based ultrasonic assisted extraction of puerarin from Radix Puerariae Lobatae by response surface methodology

“…Recently, a novel ionic liquid based ultrasonic assisted extraction (ILUAE) has been developed, combining the advantages of UAE and beneficial properties of ILs. Therefore, the ILUAE is becoming one of the attractive and promising extraction techniques (Cao et al, 2009;Wu et al, 2009;Zhang et al, 2009Zhang et al, , 2011Ma, Qiao, et al, 2011;Ma, Liu, et al, 2011).…”

“…These intrinsic features of ILs, combined with their ease of preparation, have resulted in a remarkable increase in their use in academia and industry (Sun & Armstrong, 2010). Now ILs have been successfully applied for the IL based extraction of bioactive compounds (Poole & Poole, 2010) from medicinal plants, such as alkaloids (Cao, Ye, Lu, Yu, & Mo, 2009;Du, Xiao, Xu, & Li, 2010;Lu, Ma, Hu, Dai, & Pan, 2008;Ma et al, 2010;Zhang et al, 2009), lactones (Chi et al, 2011), polyphenolic compounds (Du, Xiao, Luo, & Li, 2009;Du et al, 2007;Ma, Liu, et al, 2011;Ma, Qiao, et al, 2011), flavonoids (Du, Xiao, & Li, 2011;Huang & Xie, 2010;Zeng, Wang, Kong, Nie, & Yuan, 2010), phenolic acids and quinones (Wu et al, 2009). Recently, a novel ionic liquid based ultrasonic assisted extraction (ILUAE) has been developed, combining the advantages of UAE and beneficial properties of ILs.…”

Application of an Ionic Liquid in the Microwave Assisted Extraction of Cytotoxic Metabolites from Fruits of Schinus terebinthifolius Raddi (Anacardiaceae)

“…17 Additionally, ionic liquids in combination with more efficient extraction processes, such as microwave or ultrasound, have been successfully employed to extract various types of natural products including alkaloids, phenolic derivatives, terpenes and other metabolites. [18][19][20][21][22][23][24][25][26][27][28][29] Due to the high viscosity of the ionic liquids, usually they are used dissolved in water, which lowers the cost of the process. Finally, it is noteworthy that ionic liquids are compounds that absorb microwave very efficiently, making them excellent solvents when this technology is required.…”