Ionic liquid-based salt-induced liquid-liquid extraction of polyphenols and anthraquinones in Polygonum cuspidatum

Wang, Jialin; Feng, Jie; Xu, Lu; Ma, Jinpeng; Li, Jilong; Ma, Rui; Sun, Kun; Wang, Zhibing; Zhang, Hanqi

doi:10.1016/j.jpba.2018.09.050

Cited by 33 publications

(15 citation statements)

References 49 publications

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“…The collected data were analysed using one-way and twoway analysis of variance (ANOVA) followed by Duncan's multiple range tests using IBM (Wang et al 2019). Moreover, Ezhilan and Neelamegam (2012) identified five major compounds in the ethanolic extract of P. chinense using GC-MS chromatogram analysis, where four of them (squalene, 1,2-benzenedicarboxylic acid, mono (2-ethylhexyl) ester, 1,2-benzenedicarboxylic acid, diheptylester and 8-, methyloctahydrocoumarin) had been reported to possess antimicrobial activity.…”

Section: Discussionmentioning

confidence: 99%

Bactericidal Efficacy of Selected Medicinal Plant Crude Extracts and their Fractions against Common Fish Pathogens

Razak¹,

Shariff²,

Yusoff³

et al. 2019

JSM

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The emergence of new diseases and the increased use of antibiotics have led to the development of resistant bacterial strains. Thus, there is greater attention to seek new antibacterial agents from the natural sources for combating fish diseases in the aquaculture industry. The present study evaluated the bactericidal efficacy of crude methanolic and aqueous extracts from Polygonum chinense, Syzygium polyanthum, Premna foetida, Pimenta dioica, Brucea javanica, Vitex negundo, Alpinia conchigera and Clinacanthus nutans against Vibrio harveyi, Vibrio alginolyticus, Vibrio parahaemolyticus and Aeromonas hydrophila using disc diffusion method. The results showed that methanolic extracts of P. dioica, P. foetida and P. chinense, and aqueous extracts of P. dioica and S. polyanthum showed moderate to strong activity (10.8 to 17.2 mm) against all the tested bacteria. These five potential crude extracts were fractionated using liquid-liquid extraction method to obtain the methanol, dichloromethane and ethyl acetate fractions. Among the fractions, ethyl acetate fraction showed the highest activity against all tested bacteria, with minimum inhibition concentration (MIC) values between 0.625 and 10.000 mg/mL. In addition, the five potential crude extracts had low to moderate toxicity with LC 50 >100 µg/ mL using brine shrimp cytotoxicity assays. The results of this study indicated that methanolic extracts of P. chinense and P. foetida that showed high bactericidal activity and low toxicity could be good potentials for use in fish culture.

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Section: Discussionmentioning

confidence: 99%

Bactericidal Efficacy of Selected Medicinal Plant Crude Extracts and their Fractions against Common Fish Pathogens

Razak¹,

Shariff²,

Yusoff³

et al. 2019

JSM

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“…The HLLE in this case should start with forming a single homogenous phase, then adding a definite amount of EPPS until complete phase separation was achieved, and EPPS was precipitated. As shown in Table 2, SALLE has been extensively used in drugs [71][72][73], toxicants [74], pesticides [75] and active ingredients [76] in various matrices including biological fluids [77,78], food products [19,79], and water [80].…”

Section: F I G U R E 1 Procedures Of Salting-out Induced Homogeneous Liquid-liquid Extractionmentioning

confidence: 99%

Homogeneous liquid–liquid extraction as an alternative sample preparation technique for biomedical analysis

Hammad

Abdallah

Bedair

et al. 2021

J of Separation Science

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Liquid-liquid extraction is a widely used technique of sample preparation in biomedical analysis. In spite of the high pre-concentration capacities of liquidliquid extraction, it suffers from a number of limitations including time and effort consumption, large organic solvent utilization, and poor performance in highly polar analytes. Homogeneous liquid-liquid extraction is an alternative sample preparation technique that overcomes some drawbacks of conventional liquid-liquid extraction, and allows employing greener organic solvents in sample treatment. In homogeneous liquid-liquid extraction, a homogeneous phase is formed between the aqueous sample and the water-miscible extractant, followed by chemically or physically induced phase separation. To form the homogeneous phase, aqueous samples are mixed with water-miscible organic solvents, waterimmiscible solvents/cosolvents, surfactants, or smart polymers. Then, phase separation is induced chemically (adding salt, sugar, or buffer) or physically (changing temperature or pH). This mode is rapid, sustainable, and cost-effective in comparison with other sample preparation techniques. Moreover, homogeneous liquid-liquid extraction is more suitable for the extraction of delicate macromolecules such as enzymes, hormones, and proteins and it is more compatible with liquid chromatography with tandem mass spectrometry, which is a vital technique in metabolomics and proteomics. In this review, the principle, types, applications, automation, and technical aspects of homogeneous liquid-liquid extraction are discussed.

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“…As another kind of green solvent after water and supercritical carbon dioxide, ionic liquid has unique physical and chemical properties, such as negligible vapor pressure, good thermal and chemical stability, high solubility to organic and inorganic substances, and modifiable chemical structure [25][26][27][28]. As a green environmental solvent, ionic liquid has been widely used to extract active ingredients from natural products [29].…”

Section: Introductionmentioning

confidence: 99%

Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with HPLC and Artificial Neural Network Analysis for Ganoderma lucidum

Cui

Lü

et al. 2020

Molecules

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Ganoderma lucidum is widely used in traditional Chinese medicine (TCM). Ganoderic acid A and D are the main bioactive components with anticancer effects in G. lucidum. To obtain the maximum content of two compounds from G. lucidum, a novel extraction method, an ionic liquid-based ultrasonic-assisted method (ILUAE) was established. Ionic liquids (ILs) of different types and parameters, including the concentration of ILs, ultrasonic power, ultrasonic time, rotational speed, solid–liquid ratio, were optimized by the orthogonal experiment and variance analysis. Under these optimal conditions, the total extraction yield of the two compounds in G. lucidum was 3.31 mg/g, which is 36.21% higher than that of the traditional solvent extraction method. Subsequently, an artificial neural network (ANN) was developed to model the performance of the total extraction yield. The Levenberg–Marquardt back propagation algorithm with the sigmoid transfer function (logsig) at the hidden layer and a linear transfer function (purelin) at the output layer were used. Results showed that single hidden layer with 9 neurons presented the best values for the mean squared error (MSE) and the correlation coefficient (R), with respectively corresponding values of 0.09622 and 0.93332.

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Ionic liquid-based salt-induced liquid-liquid extraction of polyphenols and anthraquinones in Polygonum cuspidatum

Cited by 33 publications

References 49 publications

Bactericidal Efficacy of Selected Medicinal Plant Crude Extracts and their Fractions against Common Fish Pathogens

Bactericidal Efficacy of Selected Medicinal Plant Crude Extracts and their Fractions against Common Fish Pathogens

Homogeneous liquid–liquid extraction as an alternative sample preparation technique for biomedical analysis

Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with HPLC and Artificial Neural Network Analysis for Ganoderma lucidum

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