Ionic liquid-based aqueous two-phase system, a sample pretreatment procedure prior to high-performance liquid chromatography of opium alkaloids

Li, Shehong; He, Chiyang; Liu, Huwei; Li, Kèan; Li, Feng

doi:10.1016/j.jchromb.2005.08.005

Cited by 230 publications

(160 citation statements)

References 19 publications

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“…Apart from proteins like bovine serum albumin, lysozyme, trypsin, myoglobin (Pei et al, 2009, Du et al, 2007Dreyer & Kragl, 2008;Dreyer and Kragl, 2009) ATPS have been used for the recovery of small organic and inorganic molecules such as metal ions, radiochemicals, dyes, drug molecules (Huddleston et al, 1999;Willauer et al, 2002;Zhu et al, 2001;Bridges & Rogers, 2008). Short chain alcohols (Gutowski et al, 2003), phenol (Chen et al, 2009), testosterone and epitestosterone (He et al, 2005), penicillin G , opium alkaloids (Li et al, 2005a), L-tryptophan Ventura et al, 2009;Louros et al, 2010), antibiotics (Dominguez-Perez et al, 2010), caffeine and nicotine have been analysed as partitioning solutes so far. Biphasic liquid systems could find special applications in countercurrent chromatography (CCC) where both the mobile and stationary phase are immiscible liquids.…”

Section: Aqueous Biphasic Systems Based On Ionic Liquidmentioning

confidence: 99%

Ionic Liquids in Separation Techniques

Flieger¹,

Czajkowska-Żelazko²

2011

Applications of Ionic Liquids in Science and Technology

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Section: Aqueous Biphasic Systems Based On Ionic Liquidmentioning

confidence: 99%

Ionic Liquids in Separation Techniques

Flieger¹,

Czajkowska-Żelazko²

2011

Applications of Ionic Liquids in Science and Technology

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“…It was already shown that ATPS formed by K 3 PO 4 and ILs are extremely advantageous for the partition of several biomolecules yielding larger partition coefficients than those conventionally obtained with polymer-inorganic salts or polymer-polymer ATPS [6,10,13]. The extractive potential of biomolecules using IL-based ATPS was previously studied for distinct compounds, such as testosterone and epitestosterone, alkaloids, antibiotics, bovine serum albumin, penicillin G, ltryptophan and food coulorants [6,10,13,[20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Extraction of vanillin using ionic-liquid-based aqueous two-phase systems

Cláudio

Freire

et al. 2010

Separation and Purification Technology

182

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a b s t r a c tTo explore proper extractive solvents and to design an optimized separation process it is highly imperative to understand the molecular-based phenomena governing the solutes partitioning. Moreover, the development of new techniques for the biomolecules separation and purification, while maintaining their functional characteristics unchanged, is still ongoing. Therefore, in this work, the partition coefficients of vanillin, a compound with well-known organoleptic properties, were determined using improved ionicliquid-based aqueous two-phase systems (ATPS). Three main parameters were evaluated through the vanillin partitioning process: the ionic liquid (IL) cation and anion structure, the temperature of equilibrium and the available concentration of vanillin in the global system. In all systems and conditions tested, vanillin preferentially migrates for the IL-rich phase. In addition, the three studied parameters largely influence the vanillin partitioning. In an attempt to elucidate the thermodynamics of the partitioning process, the standard molar thermodynamic functions of transfer of vanillin were also determined based on the temperature dependence data. These data indicate that the partition of vanillin results from an interplay between enthalpic and entropic contributions where both the IL anion and more complex cations play an essential role. Moreover, viscosities and densities of both aqueous phases were experimentally measured at the mass fraction compositions for which the partition coefficients were determined. The results gathered in this work indicate that IL-based ATPS can be further employed in the extraction and purification of vanillin from different matrices, as confirmed by the large partition coefficients obtained and improved low viscosity systems.

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“…Some research groups have also studied the aggregation and micelles formation of ionic liquids in aqueous solution [32]. As RTILs can dissolve many kinds of organic, organometallic and inorganic compounds [33,34], their applications in analytical chemistry have also received attentions recently [35][36][37][38][39]. He et al determined the testosterone and epitestosterone in human urine using cloud extraction method based on aqueous two-phase systems consisting of ionic liquid 1-butyl-3-methylimidazolium chloride, coupled with HPLC/spectrophotometry detection, the detection limit of 1 ng/mL was obtained [38].…”

Section: Introductionmentioning

confidence: 99%

Analysis of phthalates via HPLC-UV in environmental water samples after concentration by solid-phase extraction using ionic liquid mixed hemimicelles

Cai

Shi

et al. 2008

Talanta

154

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Ionic liquid mixed hemimicelles-based solid-phase extraction for the preconcentration of five phthalates in environmental water sample was investigated in this paper. A comparative study on the use of room temperature ionic liquids (RTILs) 1-hexyl-3-methylimidazolium bromide ([C 6 mim]Br) and 1-dodecyl-3-methylimidazolium bromide ([C 12 mim]Br)-coated silica as sorbents was presented. Owing to having bigger adsorption amounts for analytes [C 12 mim], Br-coated silica was selected as SPE material and the five analytes di-ethyl-phthalate (DEP), di-n-propyl-phthalate (DnPP), di-n-butyl-phthalate (DnBP), di-cyclohexyl-phthalate (DcHP) and di-(2-ethylhexyl)-phthalate (DEHP) can be quantitatively extracted under optimal conditions. The analytes retained on the cartridge were desorbed completely with 3 mL methanol (pH 2). Predominant factors influencing the extraction efficiency, such as RTILs concentration, pH value, ionic strength and breakthrough volume were discussed. The proposed method had been applied to determining the five phthalates in four environmental water samples and concentration factor of 600 was achieved easily. Detection limits obtained ranged between 0.12 and 0.17 g/L. The accuracy of this method was evaluated by recovery measurement on spiked samples, and good recovery results (85-107%) with relative standard deviation (R.S.D.) of below 6% were achieved.

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Ionic liquid-based aqueous two-phase system, a sample pretreatment procedure prior to high-performance liquid chromatography of opium alkaloids

Cited by 230 publications

References 19 publications

Ionic Liquids in Separation Techniques

Ionic Liquids in Separation Techniques

Extraction of vanillin using ionic-liquid-based aqueous two-phase systems

Analysis of phthalates via HPLC-UV in environmental water samples after concentration by solid-phase extraction using ionic liquid mixed hemimicelles

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