Ionic Liquid‐Assisted Extraction and Isolation of Cynaropicrin and Cnicin from Artichoke and Blessed thistle

Mizuno, Hitomi; Usuki, Toyonobu

doi:10.1002/slct.201703063

Cited by 12 publications

(10 citation statements)

References 27 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cnicin 7 is isolated from artichoke and blessed thistle. 66 While it exerts its activity through covalently binding to the thiol group of Cys115, it is thought that the unsaturated ester side chain is essential to its activity from a structure-activity relationship (SAR) study. 67 Fosfomycin 8 is a phosphoenolpyruvate analogue produced by Streptomyces fradiae; moreover, it alkylates the active site Cys115 of MurA, causing bactericidal activity.…”

Section: Mray Inhibitorsmentioning

confidence: 99%

Peptidoglycan pathways: there are still more!

et al. 2019

View full text Add to dashboard Cite

show abstract

Section: Mray Inhibitorsmentioning

confidence: 99%

Peptidoglycan pathways: there are still more!

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Cnicin (Fig. 1) is a sesquiterpene lactone identified from the genus Centaurea (Mizuno and Usuki 2018). This compound shows allelopathic, antibacterial, cytotoxic, anti-myeloma, schistosomicidal, and cytostatic potential (Al-Snafi 2016; Bach et al 2011;Queiroz et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Cnicin from Centaurea benedicta L. is an active compound against skin inflammation in a mouse model

Sousa

Gonçalves

Queiroz

et al. 2021

Preprint

View full text Add to dashboard Cite

Centaurea benedicta L., commonly known as “cardo santo,” is used as a tonic, antidepressant, anti-inflammatory, antibacterial, and antiseptic in traditional medicine. This study evaluated the topical anti-inflammatory potential of an extract (ECB) and cnicin (CNI) from C. benedicta leaves in a mouse model. Activity was assessed using the ear edema method with croton oil, phenol, capsaicin, and histamine as phlogistic agents. Myeloperoxidase (MPO), N-acetyl-β-D-glucosaminidase (NAG), nitric oxide (NO), t umor necrosis factor α (TNF-α), interleukin 6 (IL-6), and histopathology were assessed as markers of edema/inflammation. Interaction profiles between CNI and cyclooxygenase-1 and -2, induced nitric oxide synthase, and glucocorticoid receptor were examined with molecular docking. Twenty-four h after induction of inflammation, ECB and CNI treatments decreased the thickness and weight of ears by 39.59%– 94.72%. MPO, NAG, NO, TNF-α, and IL-6 levels were also reduced. Histopathological, treatments reduced edema thickness, leukocytes, and vasodilation. Inflammation induced by phenol and histamine was inhibited by ECB and CNI, and ECB suppressed capsaicin-induced inflammation. CNI interacts with cyclooxygenase-1 and nitric oxide synthase through conventional hydrogen bonds, indicating inhibition of these enzymes. ECB and its compound cnicin reduce chemically-induced inflammation in mice suggesting new possibilities for the treatment of diseases associated with dermal inflammatory processes.

show abstract

“…Ionic liquids not only have the ability to dissolve and pretreat complex raw materials, but they can be also designed to selectively extract target compounds due to their tailoring ability. Nonetheless, when compared with their use in the extraction of value added products from biomass (Passos et al, 2014), few studies addressed the ILs application in the recovery of value added compounds from real food waste (Lateef et al, 2009; Bi et al, 2010; Qin et al, 2010; Bica et al, 2011; Guolin et al, 2012; Setoguchi et al, 2012; Cláudio et al, 2013, 2018; Jiao et al, 2013; Ge et al, 2014; Hernoux-Villière et al, 2014; Zhang et al, 2015, 2017; de Faria et al, 2017; Oberleitner et al, 2017; Mizuno and Usuki, 2018). Most of these studies employed imidazolium-based ILs to recover antioxidants, vitamins, fats, sugars, and essential oils from different types of food and food waste, such as tea, fruits, vegetables, crustaceans, or used oils.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Separation of Antioxidants and Carbohydrates From Food Wastes Using Aqueous Biphasic Systems Formed by Cholinium-Derived Ionic Liquids

et al. 2019

View full text Add to dashboard Cite

The food industry produces significant amounts of waste, many of them rich in valuable compounds that could be recovered and reused in the framework of circular economy. The development of sustainable and cost-effective technologies to recover these value added compounds will contribute to a significant decrease of the environmental footprint and economic burden of this industry sector. Accordingly, in this work, aqueous biphasic systems (ABS) composed of cholinium-derived bistriflimide ionic liquids (ILs) and carbohydrates were investigated as an alternative process to simultaneously separate and recover antioxidants and carbohydrates from food waste. Aiming at improving the biocompatible character of the studied ILs and proposed process, cholinium-derived bistriflimide ILs were chosen, which were properly designed by playing with the cation alkyl side chain and the number of functional groups attached to the cation to be able to create ABS with carbohydrates. These ILs were characterized by cytotoxicity assays toward human intestinal epithelial cells (Caco-2 cell line), demonstrating to have a significantly lower toxicity than other well-known and commonly used fluorinated ILs. The capability of these ILs to form ABS with a series of carbohydrates, namely monosaccharides, disaccharides and polyols, was then appraised by the determination of the respective ternary liquid-liquid phase diagrams at 25°C. The studied ABS were finally used to separate carbohydrates and antioxidants from real food waste samples, using an expired vanilla pudding as an example. With the studied systems, the separation of the two products occurs in one-step, where carbohydrates are enriched in the carbohydrate-rich phase and antioxidants are mainly present in the IL-rich phase. Extraction efficiencies of carbohydrates ranging between 89 and 92% to the carbohydrate-rich phase, and antioxidant relative activities ranging between 65 and 75% in the IL-rich phase were obtained. Furthermore, antioxidants from the IL-rich phase were recovered by solid-phase extraction, and the IL was recycled for two more times with no losses on the ABS separation performance. Overall, the obtained results show that the investigated ABS are promising platforms to simultaneously separate carbohydrates and antioxidants from real food waste samples, and could be used in further related applications foreseeing industrial food waste valorization.

show abstract

Ionic Liquid‐Assisted Extraction and Isolation of Cynaropicrin and Cnicin from Artichoke and Blessed thistle

Cited by 12 publications

References 27 publications

Peptidoglycan pathways: there are still more!

Peptidoglycan pathways: there are still more!

Cnicin from Centaurea benedicta L. is an active compound against skin inflammation in a mouse model

Simultaneous Separation of Antioxidants and Carbohydrates From Food Wastes Using Aqueous Biphasic Systems Formed by Cholinium-Derived Ionic Liquids

Contact Info

Product

Resources

About