1968
DOI: 10.1111/j.1476-5381.1968.tb00455.x
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Ionic Influences on Succinylcholine Blockade of the Mammalian Neuromuscular Junction

Abstract: Recent studies from a number of laboratories have been concerned with the delineation of factors affecting presynaptic events in neuromuscular transmission. In particular it seems that substances which block neuromuscular transmission by processes that include depolarization of the motor end-plate have important effects on the motor nerve terminals.These effects are not only produced by drugs such as succinylcholine and decamethonium, but are also shown by acetylcholine and its stable analogues.Hubbard, Schmid… Show more

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Cited by 11 publications
(10 citation statements)
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“…The ACh-induced contraction was constant during this period, as noted by Elmqvist & Thesleff (1960). Tihe animals were then killed by a blow on the head, exsanguinated, and the innervated and denervated diaphragms set up as described previously (Freeman, 1968). Isometric tension developed by the muscles in response to drugs or electrical stimulation was recorded with Statham UC2 transducing cells and a Beckman type R dynograph recorder.…”
Section: Methodsmentioning
confidence: 93%
See 1 more Smart Citation
“…The ACh-induced contraction was constant during this period, as noted by Elmqvist & Thesleff (1960). Tihe animals were then killed by a blow on the head, exsanguinated, and the innervated and denervated diaphragms set up as described previously (Freeman, 1968). Isometric tension developed by the muscles in response to drugs or electrical stimulation was recorded with Statham UC2 transducing cells and a Beckman type R dynograph recorder.…”
Section: Methodsmentioning
confidence: 93%
“…The standard nutrient solution used has been described elsewhere (Freeman, 1968). Na+-free solutions were buffered with tris(hydroxymethyl)aminomethane hydrochloride (Tris).…”
Section: Methodsmentioning
confidence: 99%
“…This loss of distinguishing characteristics is probably related to the changes in ion permeability which occur in isolated tissues (Creese & Northover, 1961;Krnjevic & Miledi, 1958), and also to the way in which the drug reaches the receptor sites (Gibberd, 1966). The most obvious characteristic common to all isolated nerve-muscle preparations is the biphasic response of the muscle to the continuing presence of the blocking agent (Jenden, Kamijo & Taylor, 1954;Jenden, 1955;Sabawala & Dillon, 1959;Maclagan, 1962;Taylor, 1962;Whittaker, 1962a, Freeman, 1968a. This response in particular has led to many of the current theories of the mechanism of depolarizing blockade in isolated nerve-muscle preparations.…”
Section: Discussionmentioning
confidence: 99%
“…This development of tolerance is in contrast to the findings of Hansson (1958), who did not observe tachyphylaxis to suxamethonium in horses under pentobarlbitone anaesthesia, and to the findings of Thesleff (1952) and Conway (1961) in the cat. Tachyphylaxis to the neuromuscular blocking and cardiovascular effects of suxamethonium has been recorded, however, iby other workers in isolated muscle preparations (Freeman, 1967), and in the intact dog (Stevenson, 1960a), cat (Adams & Hall, 1962), and man (Graf et al, 1963).…”
Section: Discussionmentioning
confidence: 99%