Ionic cross-linked chitosan beads for extended release of ciprofloxacin: <i> In vitro</i> characterization

Abstract

Chitosan beads loaded with ciprofloxacin hydrochloride were fabricated by ionic cross-linking with sodium tripolyphosphate. The beads showed an excellent water retention property. The degradation of fabricated beads was influenced by the pH of test medium. High drug load was achieved within the bead with a short curing time. Drug release was high in acidic medium (pH 1.2) vis-à-vis intestinal medium (pH 7.4). Ciprofloxacin hydrochloride release increased with an increasing concentration of ciprofloxacin and decreasing proportion of chitosan. Drug release followed both first-order and Higuchi's root time kinetics showing non-Fickian release mechanism.

Raditya Iswandana, Kurnia Sari Setio Putri, Randika Dwiputra, Tryas Yanuari, Santi Purna Sari, Joshita Djajadisastra

“…128%, 132%, and 136% for Formula 1, 2, and 3, respectively. The swelling ratio was high at pH 1.2 in comparison to 6.8 which is in line with the earlier report by Srinatha et al [12] Phosphate buffer pH 6.8 was used as a medium to simulate a colon fluid pH. The aim of swelling ability test was to define the ability of beads to swell when the beads had reached the colon.…”

“…When the chitosan and tetrandrine mixtures were shed on TPP, beads would immediately have shaped by ionotropic gelation process. This process was happened because of the cross-linked between chitosan amine groups which had positive load and TPP with the negative ion [12].…”

Al+3 ion cross-linked and acetalated gellan hydrogel network beads for prolonged release of glipizide

“…Chitosan is at the origin a neutral polysaccharide whose amine functional group can be protonated in acidic pH conditions and become one of the little polysaccharides which are positively charged. The ability of chitosan to form hydrogel beads in presence of negatively charged sodium tripolyphosphate has also been investigated for controlled drug delivery (Aydin & Akbuga, 1996;Srinatha, Pandit, & Singh, 2008). However, higher porosity of sodium tripolyphosphate/chitosan beads led to rapid release of drug in acidic dissolution medium (Gupta & Ravi, 2000).…”

Formulation of Fast-Release Gastroretentive Solid Dispersion of Glibenclamide with Gelucire 50/13

“…where M t /M ∞ is the fraction of drug released in time, t, K is the structural and geometric constant, and n is the release exponent [17].…”