2020
DOI: 10.21203/rs.3.rs-96572/v1
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Ionic contrast across a lipid membrane for Debye length extension: towards an ultimate bioelectronics transducer

Abstract: Despite technological advances in biomolecule detections, evaluation of molecular interactions via potentiometric devices under ion-enriched solutions has remained a long-standing problem. To avoid severe performance degradation of bioelectronics by ionic screening effects, we cover probe surfaces of field effect transistors (FETs) with a single film of the supported lipid bilayer (SLB), and realize outstanding potentiometric signals from receptor-ligand bindings irrespective of ionic strength of bulky solutio… Show more

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