Ionic Channels in the Therapy of Malignant Glioma

Ding, Xia; He, Hua; Lu, Yao; Wang, Yizheng

doi:10.5772/24833

Cited by 2 publications

(3 citation statements)

References 170 publications

(182 reference statements)

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“…We likewise analyzed the other ion channels that were highlighted by the reviews of Ding et al, [13] + Arcangeli et al [7] and determined whether a similar effect could be seen as we saw with the BK channels in relation to glioma patient survival. Many other ion channels reported to be over-expressed with glioma cell lines also fail to show this correlation with REMBRANDT.…”

Section: An Apparent Paradox With Ion Channels Using the Current mentioning

confidence: 76%

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Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy

Hoa

Wilson

et al. 2014

International Immunopharmacology

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The Big Potassium (BK) ion channel is commonly known by a variety of names (Maxi-K, KCNMA1, slo, Stretch-activated potassium channels, KCa1.1). Each name reflects a different physical property displayed by this single ion channel. This transmembrane channel is found on nearly every cell type of the body and has its own distinctive roles for that tissue type. The BKα channel contains the pore that releases potassium ions from intracellular stores. This ion channel is found on the cell membrane, endoplasmic reticulum, Golgi and mitochondria. Complex splicing pathways produce different isoforms. The BKα channels can be phosphorylated, palmitoylated and myristylated. BK is composed of a homo-tetramer that interacts with β and γ chains. These accessory proteins provide a further modulating effect on the functions of BKα channels. BK channels play important roles in cell division and migration. In this review, we will focus on the biology of BK channels, especially its role, and that it has in the immune response towards cancer. Recent proteomic studies have linked BK channels with various proteins. Some of these interactions offer further insight into the role that BK channels have with cancers, especially with brain tumors. This review shows that BK channels have a complex interplay with intracellular components of cancer cells and still have plenty of secrets to be discovered.

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Section: An Apparent Paradox With Ion Channels Using the Current mentioning

confidence: 76%

“… The ion channels that were discussed in Arcabeli, et al [7] and Ding, et al [13] dealing with gliomas were examined by REMBRANDT analysis of gene expression and survival for all gliomas (522 patients). The number of patients that had either over-expression (>2.0 fold) or under-expression (<2.0 fold) are reported.…”

Section: Figurementioning

confidence: 99%

Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy

Hoa

Wilson

et al. 2014

International Immunopharmacology

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“…Here we will briefly touch upon channel expression, subtype, and pH-sensitivity as discussed in brain tumor literature. For a broader view of pH-sensitive ion channels and cancer, see Glitsch (2011); for a more in-depth view of ion channels in brain tumors, see Ding et al (2012). …”

Section: Ion Channel Signalingmentioning

confidence: 99%

Involvement of tumor acidification in brain cancer pathophysiology

Honasoge

Sontheimer

2013

Front. Physiol.

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Gliomas, primary brain cancers, are characterized by remarkable invasiveness and fast growth. While they share many qualities with other solid tumors, gliomas have developed special mechanisms to convert the cramped brain space and other limitations afforded by the privileged central nervous system into pathophysiological advantages. In this review we discuss gliomas and other primary brain cancers in the context of acid-base regulation and interstitial acidification; namely, how the altered proton (H+) content surrounding these brain tumors influences tumor development in both autocrine and paracrine manners. As proton movement is directly coupled to movement of other ions, pH serves as both a regulator of cell activity as well as an indirect readout of other cellular functions. In the case of brain tumors, these processes result in pathophysiology unique to the central nervous system. We will highlight what is known about pH-sensitive processes in brain tumors in addition to gleaning insight from other solid tumors.

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Ionic Channels in the Therapy of Malignant Glioma

Cited by 2 publications

References 170 publications

Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy

Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy

Involvement of tumor acidification in brain cancer pathophysiology

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