Ionic Basis for Serotonin-Induced Bistable Membrane Properties in Guinea Pig Trigeminal Motoneurons

Hsiao, Chie-Fang; Negro, Christopher A. Del; Trueblood, Peggy R.; Chandler, Scott H.

doi:10.1152/jn.1998.79.6.2847

Cited by 122 publications

(146 citation statements)

References 58 publications

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“…The results of Fig. 4 reinforce the idea that the L-type (in particular the Cav1.3 isoform) are the Ca 2+ channels that are potentially able to control the firing rate of neurons and cardiac cells because of their lowthreshold of activation [20,69,70]. Future experiments using action potential-clamps and specific pharmacological dissections of inward and outward currents contributing to the shape of action potentials will allow to determine more precisely the role and contribution of L-type channels to the electrically activity of chromaffin cells.…”

Section: L-type Channels Control the Firing Frequency Of Spontaneouslsupporting

confidence: 71%

L-type calcium channels in adrenal chromaffin cells: Role in pace-making and secretion

et al. 2007

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Voltage-gated L-type (Cav1.2 and Cav1.3) channels are widely expressed in cardiovascular tissues and represent the critical drug-target for the treatment of several cardiovascular diseases. The two isoforms are also abundantly expressed in neuronal and neuroendocrine tissues. In the brain, Cav1.2 and Cav1.3 channels control synaptic plasticity, somatic activity, neuronal differentiation and brain aging. In neuroendocrine cells, they are involved in the genesis of action potential generation, bursting activity and hormone secretion.Recent studies have shown that Cav1.2 and Cav1.3 are also expressed in chromaffin cells but their functional role has not yet been identified despite that L-type channels possess interesting characteristics, which confer them an important role in the control of catecholamine secretion during action potentials stimulation. In intact rat adrenal glands L-type channels are responsible for adrenaline and noradrenaline release following splanchnic nerve stimulation or nicotinic receptor activation. L-type channels can be either up-or down-modulated by membrane autoreceptors following distinct second messenger pathways. L-type channels are tightly coupled to BK channels and activate at relatively low-voltages. In this way they contribute to the action potential hyperpolarization and to the pace-maker current controlling action potential firings. L-type channels are shown also to regulate the fast secretion of the immediate readily releasable pool of vesicles with the same Ca 2+ -efficiency of other voltage-gated Ca 2+ channels. In mouse adrenal slices, repeated action potential-like stimulations drive L-type channels to a state of enhanced stimulus-secretion efficiency regulated by ␤-adrenergic receptors.Here we will review all these novel findings and discuss the possible implication for a specific role of L-type channels in the control of chromaffin cells activity.

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Section: L-type Channels Control the Firing Frequency Of Spontaneouslsupporting

confidence: 71%

L-type calcium channels in adrenal chromaffin cells: Role in pace-making and secretion

et al. 2007

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“…There is recent evidence that PICs include tetrodotoxin(TTX)-sensitive "persistent" sodium currents (Lee & Heckman,2001;Li and Bennett, 2003; for a similar finding on brainstem motoneurons, see Nishimura et al, 1989;Hsiao et al, 1998). Li and Bennett (2003) demonstrated inward currents seen during slow ramp depolarizations that were insensitive to dihydropridines and blocked by TTX.…”

Section: The Role Of Motoneuron Dendrites In Repetitive Firingmentioning

confidence: 93%

Beginning at the end: Repetitive firing properties in the final common pathway

Brownstone

2006

Progress in Neurobiology

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Since the early 20th century, it has been recognized that motoneurons must fire repetitive trains of action potentials to produce muscle contraction. In 1932, Sir John Eccles, together with Hebbel Hoff, found that action potential spike trains in motor axons were produced by "rhythmic centres", which were within the motoneurons themselves. Two decades later, Eccles attended a Cold Spring Harbor Symposium in NY, USA entitled "The Neuron". Two of the many notable presentations at this symposium were juxtaposed: one by Eccles from the University of Otago, Dunedin, NZL, and the other by J. Walter Woodbury and Harry Patton from the University of Washington, Seattle, USA. Both presentations included data obtained using sharp microelectrodes to study the intracellularly recorded potentials of cat motoneurons. In this review, I discuss some of the events leading up to and surrounding this jointly accomplished advance and proceed to discussion of subsequent studies over 5+ decades that have made use of intracellular recordings from motoneurons to study their repetitive firing behavior. This begins with early descriptions of primary and secondary range firing, and continues to the discovery of dendritic persistent inward currents and their relation to plateau potentials, synaptic amplification, and motoneuronal firing. Following a brief description of the possible mechanisms underlying spike frequency adaptation, I discuss the modulation of repetitive firing properties during various motor behaviors. It has become increasingly clear that the central nervous system has exquisite control of the repetitive firing of motoneurons. Eccles' work laid the foundation for the present-day study of these processes.

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“…Our previous studies indirectly characterized the ionic currents responsible for trigeminal sensory and motoneuronal excitability based on pharmacological dissection (Hsiao et al, 1998;Wu et al, 2001Wu et al, , 2005Tanaka et al, 2003). Although useful, as pointed out previously (Swensen and Bean, 2003), with that type of analysis, the interpretation can be misleading, because blocking one conductance can alter the subsequent voltage trajectory and underlying conductance of another ion channel.…”

Section: Contribution Of Sodium Current Components To Spike Dischargementioning

confidence: 99%

Participation of Sodium Currents in Burst Generation and Control of Membrane Excitability in Mesencephalic Trigeminal Neurons

Enomoto¹,

Han²,

Hsiao³

et al. 2006

J. Neurosci.

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Subthreshold sodium currents are important in sculpting neuronal discharge and have been implicated in production and/or maintenance of subthreshold membrane oscillations and burst generation in mesencephalic trigeminal neurons (Mes V). Moreover, recent data suggest that, in some CNS neurons, resurgent sodium currents contribute to production of high-frequency burst discharge. In the present study, we sought to determine more directly the participation of these currents during Mes V electrogenesis using the action potentialclamp method. In postnatal day 8 -14 rats, the whole-cell patch-clamp method was used to record sodium currents by subtraction in response to application of TTX in voltage-clamp mode using the action potential waveform as the command protocol. We found that TTX-sensitive sodium current is the main inward current flowing during the interspike interval, compared with the h-current (I h ) and calcium currents. Furthermore, in addition to the transient sodium current that flows during the upstroke of action potential, we show that resurgent sodium current flows at the peak of afterhyperpolarization and persistent sodium current flows in the middle of the interspike interval to drive high-frequency firing. Additionally, transient, resurgent, and persistent sodium current components showed voltage-and time-dependent slow inactivation, suggesting that slow inactivation of these currents can contribute to burst termination. The data suggest an important role for these components of the sodium current in Mes V neuron electrogenesis.

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Ionic Basis for Serotonin-Induced Bistable Membrane Properties in Guinea Pig Trigeminal Motoneurons

Cited by 122 publications

References 58 publications

L-type calcium channels in adrenal chromaffin cells: Role in pace-making and secretion

L-type calcium channels in adrenal chromaffin cells: Role in pace-making and secretion

Beginning at the end: Repetitive firing properties in the final common pathway

Participation of Sodium Currents in Burst Generation and Control of Membrane Excitability in Mesencephalic Trigeminal Neurons

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