Ion-trap mass spectrometry for determination of 3,5,3′-triiodo-l-thyronine and 3,5,3′,5′-tetraiodo-l-thyronine in neonatal rat cardiomyocytes

HPLC method for levothyroxine quantification in long-acting drug delivery systems. Validation and evaluation of bovine serum albumin as levothyroxine stabilizer

“…Obviously, there are methods with lower limits of detection/quantification using mass spectrometry detection or not conventional detectors. However, these methods are developed to quantify LEVO within biological matrices [29,30]. This analytical method was validated according to the ICH guidelines [15].…”

Identification and quantification of electrochemically generated metabolites of thyroxine by means of liquid chromatography/electrospray-mass spectrometry and countergradient liquid chromatography/inductively coupled plasma-mass spectrometry

“…Different protocols for iodine speciation analysis, although without the countergradient approach, have been published previously [39][40][41][42][43], as well as methods specific for thyroid hormones determination [44][45][46][47][48][49][50][51]. However, there are no reports in literature on the simultaneous identification and quantification of T 4 and its (electrogenerated) oxidation products with countergradient elution.…”