Ion trap mass spectrometry

March, Raymond E.

doi:10.1016/0168-1176(92)85059-9

Cited by 117 publications

(74 citation statements)

References 166 publications

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“…Space-charge effects are not negligible in this situation. It is supposed that optical frequency standards based on multipole traps should be able to achieve sensibly higher accuracy, required by applications such as satellite-based navigation (GPS), quantum metrology or precision measurements on variations of the fundamental constants in physics 6, 25,44,45,72 .…”

Section: Microparticles Investigation Methodsmentioning

confidence: 99%

Multipole electrodynamic ion trap geometries for microparticle confinement under standard ambient temperature and pressure conditions

Mihalcea

Giurgiu

Stan

et al. 2016

Journal of Applied Physics

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Trapping of microparticles and aerosols is of great interest for physics and chemistry.We report microparticle trapping in case of multipole linear Paul trap geometries, operating under Standard Ambient Temperature and Pressure (SATP) conditions. An 8-electrode and a 12-electrode linear trap geometries have been designed and tested with an aim to achieve trapping for larger number of particles and to study microparticle dynamical stability in electrodynamic fields. We report emergence of planar and volume ordered structures of microparticles, depending on the a.c. trapping frequency and particle specific charge ratio. The electric potential within the trap is mapped using the electrolytic tank method. Particle dynamics is simulated using a stochastic Langevin equation. We emphasize extended regions of stable trapping with respect to quadrupole traps, as well as good agreement between experiment and numerical simulations.

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Section: Microparticles Investigation Methodsmentioning

confidence: 99%

Multipole electrodynamic ion trap geometries for microparticle confinement under standard ambient temperature and pressure conditions

Mihalcea

Giurgiu

Stan

et al. 2016

Journal of Applied Physics

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“…A brief analysis of the stability equations for a QITMS will demonstrate the effect of this new dc potential. The canonical Mathieu formulae for the so-called axial stability parameters in the QITMS, a z and q z , are given in eqs 3 and 4, where e is the fundamental unit of charge, V and U are the amplitudes of the maximum zero-to-peak radio frequency (rf) and dc trapping potentials, m is mass, r 0 is the radius of the ring electrode, z 0 is axial spacing of endcap electrodes, and ⍀ is the angular frequency of the rf trapping voltage [17].…”

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confidence: 99%

“…During isolation, the ion cloud will experience several different trapping environments, most notably a gain in kinetic energy as the q z value approaches a resonant ejection point, and a decrease in the depth of the pseudopotential trapping well as q z is reduced to the value used for CID. The depth of the pseudopotential well is given in eq 7 [17,18].…”

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confidence: 99%

On the time scale of internal energy relaxation of AP-MALDI and nano-ESI Ions in a quadrupole ion trap

Remes

Glish

2009

J. Am. Soc. Mass Spectrom.

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Recently reported results (Konn et al. [14]) on the collisional cooling of atmospheric pressure matrix assisted laser desorption ionization (AP-MALDI) and nano-electrospray ionization (nano-ESI) generated ions in a quadrupole ion trap mass spectrometer (QITMS) are inconsistent with measured collisional cooling rates. The work reported here presents a re-examination of those previous results. Collision induced dissociation (CID) has been used to probe various properties of ions contained in a QITMS. It is shown experimentally that when trapping large numbers of ions, an effective dc trapping voltage is induced that varies with changes in the size of the ion cloud. A decrease in the resonant frequency for maximum CID efficiency is observed as the cool time between parent ion isolation and CID is increased. Ion trajectories in a QITMS are simulated to demonstrate how ion density changes over the course of parent ion isolation. The effect of space charge on ion motion is simulated, and Fourier transformations of ion axial motion plus simple calculations corroborate the experimentally observed transient frequency shifts. The relative stability of ions formed by AP-MALDI and nano-ESI is compared under low charge density conditions. These data show that the ions have reached equilibrium internal energy and, thus, that differences in dissociation onsets and "50% fragmentation efficiency points" between the ionization mechanisms are due to the formation of distinct ion conformations as previously shown in reference [28] A n understanding of ion internal energy is of primary interest to researchers studying the structures of gas-phase ions. How fast an ion will dissociate, which mechanisms will be involved, and how many products will be observed all have a large dependence on the amount of internal energy in the ion and the experimental time window for dissociation [1][2][3][4]. If the internal energy of an ion is distributed statistically among its bonds, RRKM theory can determine the dissociation kinetics of the various dissociation pathways, and mass spectra or tandem mass spectra (MS/MS) could be predicted [5][6][7]. MS/MS spectra are related to ion structure on a fundamental level because the vibrational bond frequencies, the ground state energy, and the critical energy of dissociation are all determined on some level by the three dimensional conformation of the ion.Because MS/MS spectra have a dependence on structure and internal energy, it is important to understand the various factors that determine ion internal energy and how its magnitude might change over the course of an experiment. A typical experiment using a quadrupole ion trap mass spectrometer (QITMS) lasts several hundred ms, during which time a large number of variables can affect an ion population's distribution of internal energy. The theoretical calculation of ion internal energy in a QITMS is a complex quantum chemical calculation in which many factors must be considered, such as the kinetic energy of the ion, the vibrational energy states of the io...

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“…I on trap mass spectrometers are one of the most common and powerful mass analyzers in use because they have a relatively high scan speed, are sensitive, and are inherently capable of performing MS n experiments [1][2][3]. Also, ion traps are well suited for pulsed laser experiments such as MALDI because, as is the case with time-of-flight (TOF) instruments, a mass spectrum of the entire sample can be obtained from a single laser shot.…”

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confidence: 99%

Direct determination of polycyclic aromatic hydrocarbons in solid matrices using laser desorption/laser photoionization ion trap mass spectrometry

Specht

Blades

2003

J. Am. Soc. Mass Spectrom.

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The development and characterization of a new instrument for solid sampling which couples IR laser desorption followed by UV laser photo-ionization and analysis using an ion trap mass spectrometer has been investigated. For calibration, a new type of solid sample preparation involving activated charcoal as the solid substrate was used. This solid sample provided a steady signal for several thousand laser shots, which allowed optimization of the experimental procedure. It was found that both the IR and UV intensity and the delay between them play an important role in both the magnitude and type of signals observed. A method of gas phase accumulation with multiple laser shots was examined. Finally, this technique was demonstrated to be effective in providing direct qualitative information for N.I.S.T. SRM 1944 river sediment sample with no sample pre-treatment.

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Ion trap mass spectrometry

Cited by 117 publications

References 166 publications

Multipole electrodynamic ion trap geometries for microparticle confinement under standard ambient temperature and pressure conditions

Multipole electrodynamic ion trap geometries for microparticle confinement under standard ambient temperature and pressure conditions

On the time scale of internal energy relaxation of AP-MALDI and nano-ESI Ions in a quadrupole ion trap

Direct determination of polycyclic aromatic hydrocarbons in solid matrices using laser desorption/laser photoionization ion trap mass spectrometry

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