Ion transfer through a liquid membrane or a bilayer lipid membrane in the presence of sufficient electrolytes

Shirai, Osamu; Kihara, Sorin; Yoshida, Yumi; Matsui, Masanao

doi:10.1016/0022-0728(94)03852-t

Cited by 100 publications

(86 citation statements)

References 26 publications

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“…Ulmeanu et al used cyclic voltammetry and pH profiling to determine the partition coefficient of drugs using a commercial 96-well micro-filter plate system, which by nature requires only a small amount of the organic solvent and studied drug [58]. Other reports made significant contribution to the polarised membrane research, albeit not directly studying pharmaceutically relevant molecules [59][60][61][62][63]. Significant efforts have also been spent on development of an electrochemical theory to describe the observed current-potential dependence, both for systems with and without membrane electrolytes [64][65][66][67].…”

Section: Voltammetry In Membrane Permeability Studiesmentioning

confidence: 99%

Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs

et al. 2014

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In this review, we will briefly outline the voltammetric investigations of the transfer of ionisable drugs at the interface between two immiscible electrolyte solutions. The voltammetric techniques enable the determination of some key in vitro properties of ionisable drugs, including partition coefficient, diffusioncoefficient and membrane permeability. Some successful applications will be highlighted, together with the background methodologies.

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Section: Voltammetry In Membrane Permeability Studiesmentioning

confidence: 99%

Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs

et al. 2014

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“…In this chapter, the method proposed by the present authors for the elucidation of the charge transport process through an LM in the presence of sufficient electrolytes 38 is introduced, and a few membrane phenomena of which mechanisms were elucidated by the method are introduced.…”

Section: Biomimetic Charge Transfer Reactions Observed By Artificial mentioning

confidence: 99%

“…through an LM in the presence of sufficient electrolytes 38 The membrane system of Eq. (37) is an example used in the investigation of the membrane transport process.…”

Section: Voltammetric Elucidation Of the Charge Transfer Processmentioning

confidence: 99%

Biomimetic Charge Transfer Reactions at the Aqueous/Organic Solution Interface or through Artificial Membrane

et al. 2012

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Some biomimetic reactions observed with the aid of aqueous/organic, W/O, two phases or liquid membrane, LM, systems were introduced. The reactions introduced were mostly those reported by the group of present authors as follows; (1) (5) A new type of membrane transport reaction realized in the presence of an applied electrical potential gradient parallel to the W/ membrane interface. The processes of above-described reactions were elucidated based on the voltammetric methods and concepts taking into account the properties common to both artificial LMs and biomembranes. A method proposed by present authors for the elucidation of the membrane transport process was also introduced.

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“…We found that EW1-W2 was the sum of EW1|M, EM|W2 and IW1-W2RW1-W2. 13,14 Here, RW1-W2 is the resistance between W1 and W2. When 3 phases (W1, M and W2) contain sufficient electrolytes and hence RW1-W2 is small, EW1-W2 is given as…”

Section: Characteristics Of Voltammograms At Lmdementioning

confidence: 99%

Development of Rotating Liquid Membrane Disk Electrode and Rotating Liquid Membrane Ring-Liquid Membrane Disk Electrode and Evaluation of Characteristics of Ion Transfer Reactions at the Rotating AqueouslOrganic Solution Interface

2005

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A liquid membrane disk electrode, LMDE, and a liquid membrane ring-liquid membrane disk electrode, LMRE-LMDE, were developed by placing a gelled polyvinyl chloride thin membrane impregnated with 2-nitrophenyl octyl ether, NPOE-LM, on the surface of a glassy carbon, GC, disk or ring electrode. The voltammogram for the ion transfer at the interface between an aqueous solution, W, and NPOE-LM was recorded by setting the developed electrode in W and rotating at a rate, ω, between 0 and 4000 rpm. The sensitivity of the ion-transfer current at the W|NPOE-LM interface, I, was enhanced to be more than 100 times better than that at the W|NPOE (solution) interface when LMDE was rotated at ω higher than 200 rpm. The reversibility of the ion transfer reaction could be evaluated based on the dependence of I on ω of LMDE, and the reaction product at LMDE could be identified at LMRE when the rotating LMRE-LMDE system was adopted.

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Ion transfer through a liquid membrane or a bilayer lipid membrane in the presence of sufficient electrolytes

Cited by 100 publications

References 26 publications

Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs

Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs

Biomimetic Charge Transfer Reactions at the Aqueous/Organic Solution Interface or through Artificial Membrane

Development of Rotating Liquid Membrane Disk Electrode and Rotating Liquid Membrane Ring-Liquid Membrane Disk Electrode and Evaluation of Characteristics of Ion Transfer Reactions at the Rotating AqueouslOrganic Solution Interface

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