Ion track symmetric and asymmetric nanopores in polyethylene terephthalate foils for versatile applications

Apel, P.Yu.; Blonskaya, I.V.; Dmitriev, S.N.; Orelovich, O.L.; Sartowska, B.

doi:10.1016/j.nimb.2015.07.016

Cited by 14 publications

(6 citation statements)

References 34 publications

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“…The single bullet-shaped nanopore was obtained following the method previously reported. , In brief, only one side of the tracked film is activated by UV for 26 h (Fisher Bioblock; VL215.MC, λ = 312 nm). Then, the chemical etching was performed under symmetrical conditions with NaOH 6 M and Dowfax 2A1 (EZkem, USA) 0.05% v/v at 60 °C for 8 min.…”

Section: Methodsmentioning

confidence: 99%

Detection of Amyloid-β Fibrils Using Track-Etched Nanopores: Effect of Geometry and Crowding

et al. 2021

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Several neurodegenerative diseases have been linked to proteins or peptides that are prone to aggregate in different brain regions. Aggregation of amyloid-β (Aβ) peptides is recognized as the main cause of Alzheimer's disease (AD) progression, leading to the formation of toxic Aβ oligomers and amyloid fibrils. The molecular mechanism of Aβ aggregation is complex and still not fully understood. Nanopore technology provides a new way to obtain kinetic and morphological aspects of Aβ aggregation at a single-molecule scale without labeling by detecting the electrochemical signal of the peptides when they pass through the hole. Here, we investigate the influence of nanoscale geometry (conical and bulletlike shape) of a track-etched nanopore pore and the effect of molecular crowding (polyethylene glycol-functionalized pores) on Aβ fibril sensing and analysis. Various Aβ fibril samples that differed by their length were produced by sonication of fibrils obtained in the presence of epigallocatechin gallate. The conical nanopore functionalized with polyethylene glycol (PEG) 5 kDa is suitable for discrimination of the fibril size from relative current blockade. The bullet-like-shaped nanopore enhances the amplitude of the current and increases the dwell time, allowing us to well discern the fibrils. Finally, the nanopore crowded with PEG 20 kDa enhances the relative current blockade and increases the dwell time; however, the discrimination is not improved compared to the "bullet-shaped" nanopore.

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Section: Methodsmentioning

confidence: 99%

Detection of Amyloid-β Fibrils Using Track-Etched Nanopores: Effect of Geometry and Crowding

et al. 2021

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“…The size and density of pores can be adjusted in a wide range: from a few nanometers to 15 μm for size and from 10 6 to 10 9 pores/cm 2 for density. The porosity of the membrane is mainly determined by the duration of irradiation and the pore size, and pore geometry is mainly determined by the etching time, temperature, concentration, additives and etching bath configuration [ 166 , 167 , 168 , 169 , 170 ]. It should be noted that the mechanical properties of PET film may change during TeM fabrication.…”

Section: Track-etched Membranes In Membrane Distillationmentioning

confidence: 99%

Recent Progress in the Membrane Distillation and Impact of Track-Etched Membranes

et al. 2021

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Membrane distillation (MD) is a rapidly developing field of research and finds applications in desalination of water, purification from nonvolatile substances, and concentration of various solutions. This review presents data from recent studies on the MD process, MD configuration, the type of membranes and membrane hydrophobization. Particular importance has been placed on the methods of hydrophobization and the use of track-etched membranes (TeMs) in the MD process. Hydrophobic TeMs based on poly(ethylene terephthalate) (PET), poly(vinylidene fluoride) (PVDF) and polycarbonate (PC) have been applied in the purification of water from salts and pesticides, as well as in the concentration of low-level liquid radioactive waste (LLLRW). Such membranes are characterized by a narrow pore size distribution, precise values of the number of pores per unit area and narrow thickness. These properties of membranes allow them to be used for more accurate water purification and as model membranes used to test theoretical models (for instance LEP prediction).

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“…The track-etching of membranes is done in two steps: (i) the swift heavy-ion irradiation and (ii) the chemical etching of latent ion tracks in polymers (Figure 1i-k). Among the various techniques, ion track technology permits control over the number of pores per square centimetres of the polymer surface (from single to multipore membranes), dimensions and shape (cylindrical, conical, cigar-shaped...) [74][75][76]. It has been found that asymmetric nanopores are cation selective and have diode-like voltage-current characteristics.…”

Section: Nanopipettementioning

confidence: 99%

Solid-state and polymer nanopores for protein sensing: A review

Meyer

Nemeir

Janot

et al. 2021

Advances in Colloid and Interface Science

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Ion track symmetric and asymmetric nanopores in polyethylene terephthalate foils for versatile applications

Cited by 14 publications

References 34 publications

Detection of Amyloid-β Fibrils Using Track-Etched Nanopores: Effect of Geometry and Crowding

Detection of Amyloid-β Fibrils Using Track-Etched Nanopores: Effect of Geometry and Crowding

Recent Progress in the Membrane Distillation and Impact of Track-Etched Membranes

Solid-state and polymer nanopores for protein sensing: A review

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