Ion Selective Electrodes (ISE’s) in Clinical Chemistry

Oesch, U.; Amman, D.; Schefer, U.; Malinowska, Elżbieta; Simon, W.

doi:10.1007/978-1-4613-0753-2_25

Cited by 5 publications

(5 citation statements)

References 19 publications

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“…tridodecylamine have been reported (2) . However, the use of plasticiser in PVC membrane based electrodes were later found to be the main cause of thrombocity when used as implantable sensors (3,4) . Many polymer membranes that require less plasticisers compared with PVC were studied as sensing membrane for pH, e.g.…”

Section: Introductionmentioning

confidence: 99%

A Hydrogen Ion-Selective Sensor Based on Non-Plasticised Methacrylic-acrylic Membranes

Heng

Chern

Ahmad

2002

Sensors

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A methacrylic-acrylic polymer was synthesised for use as a non-plasticised membrane for hydrogen ion-selective sensor incorporating tridodecylamine as an ionophore. The copolymer consisted of methyl methacrylate and n-butyl acrylate monomers in a ratio of 2:8. Characterisation of the copolymer using FTNMR demonstrated that the amount of each monomer incorporated during solution polymerisation was found to be similar to the amount used in the feed before polymerisation. The glass transition temperature of the copolymer determined by differential scanning calorimetry was -30.9 ºC. Potentiometric measurements conducted showed a linear pH response range of 4.3 -9.6 with the response slope of 56.7 mV/decade. The selectivity of the sensors towards hydrogen ions was similar to other plasticiser based membrane electrodes and the logarithmic selectivity coefficients for discrimination against interference cations is close to -9.7. However, the incorporation of a lipophilic anion as membrane additive is essential in ensuring optimum performance of the hydrogen ion sensor.

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Section: Introductionmentioning

confidence: 99%

A Hydrogen Ion-Selective Sensor Based on Non-Plasticised Methacrylic-acrylic Membranes

Heng

Chern

Ahmad

2002

Sensors

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“…With this greater understanding of how anions can affect key biological processes, research in the field of anion supramolecular chemistry -anion binding and remediation utilizing noncovalent interactions [10,11] -has seen exponential growth in the last 20 years. These activities have led to applications in ion selective electrodes [12][13][14], which can be used for measuring chloride and phosphate concentrations in the human body, as well as to the design of selective receptors for use in environmental anion remediation and liquid-liquid extractions [15,16]. At the foundation of these advances in anion receptor chemistry lies the application of new synthetic methodologies to allow for the creation of these novel receptors.…”

Section: Motivationmentioning

confidence: 99%

1,2,3-Triazoles and the Expanding Utility of Charge Neutral CH···Anion Interactions

McDonald

Hua

Flood

2010

Topics in Heterocyclic Chemistry

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As the field of anion supramolecular chemistry continues to grow in its sophistication and understanding of the noncovalent interactions used to effectively bind anions, there exists new theoretical and experimental evidence for a necessary reexamination of the way in which the field views hydrogen bond donors. The heteroatom based hydrogen-bond donors (e.g., NH and OH) are well-known to provide strong stabilization to negatively charged species. However, new findings point to the untapped stabilization energy that lay dormant in extrinsically-activated CH hydrogen bonds. Computational studies showed that an activated aliphatic or aromatic CH can provide an amount of anion stabilization in the gas phase approaching that of conventional NH based donors. Discovery of the Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition to provide 1,2,3-triazoles and the ability to readily "click" this functionality into anion receptors has allowed extensive experimental investigation of the ideas posed by these calculations. This chapter will focus on the evolution of the CH hydrogen bond from being viewed as a weak, secondary interaction to now being utilized as a powerful source of anion stabilization in macrocyclic and oligomeric receptors. In addition, the application of the anion binding power of the 1,2,3-triazole towards the preparation of mechanically interlocked structures will also be discussed.

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“…Over the past decades, ion-selective electrode based potentiometry has become a well-established electro analytical technique for the determination and identification of metal ions even in traces. The ion-selective electrodes (ISEs) are of wide spread interest because of their simplicity, low cost, sufficiently reliable and reasonable selectivity, nondestructiveness and fast provision for analytical results (Oesch et al 1978). Precipitate based ion-selective membrane electrodes are well known as they are successfully used for the determination of several anions and cations (Amini et al 1999a, b;Li et al 1999;Hassan et al 2000;Lindfors and Ivaska 2000;Ganjali et al 2001;Shamsipur et al 2001).…”

Section: Introductionmentioning

confidence: 99%

A new ion-selective electrode based on aluminium tungstate for Fe(III) determination in rock sample, pharmaceutical sample and water sample

Naushad

2008

Bull Mater Sci

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An inorganic cation exchanger, aluminum tungstate (AT), has been synthesized by adding 0⋅1 M sodium tungstate gradually into 0⋅1 M aluminium nitrate at pH 1⋅2 with continuous stirring. The ion exchange capacity for Na + ion and distribution coefficients of various metal ions was determined on the column of aluminium tungstate. The distribution studies of various metal ions showed the selectivity of Fe(III) ions by this cation exchange material. So, a Fe(III) ion-selective membrane electrode was prepared by using this cation exchange material as an electroactive material. The effect of plasticizers viz. dibutyl phthalate (DBP), dioctylphthalate (DOP), di-(butyl) butyl phosphate (DBBP) and tris-(2-ethylhexylphosphate) (TEHP), has also been studied on the performance of membrane sensor. It was observed that the membrane containing the composition AT: PVC: DBP in the ratio 2 : 20 : 15 displayed a useful analytical response with excellent reproducibility, low detection limit, wide working pH range (1-3⋅5), quick response time (15 s) and applicability over a wide concentration range of Fe(III) ions from 1 × 10 -7 M to 1 × 10 -1 M with a slope of 20 ± 1 mV per decade. The selectivity coefficients were determined by the mixed solution method and revealed that the electrode was selective for Fe(III) ions in the presence of interfering ions. The electrode was used for atleast 5 months without any considerable divergence in response characteristics. The constructed sensor was used as indicator electrode in the potentiometric titration of Fe(III) ions against EDTA and Fe(III) determination in rock sample, pharmaceutical sample and water sample. The results are found to be in good agreement with those obtained by using conventional methods.

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Ion Selective Electrodes (ISE’s) in Clinical Chemistry

Cited by 5 publications

References 19 publications

A Hydrogen Ion-Selective Sensor Based on Non-Plasticised Methacrylic-acrylic Membranes

A Hydrogen Ion-Selective Sensor Based on Non-Plasticised Methacrylic-acrylic Membranes

1,2,3-Triazoles and the Expanding Utility of Charge Neutral CH···Anion Interactions

A new ion-selective electrode based on aluminium tungstate for Fe(III) determination in rock sample, pharmaceutical sample and water sample

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