Ion-selective electrodes based on natural carboxylic polyether antibiotics

Suzuki, Kôji; Tohda, Koji; Aruga, Hiroshi; Matsuzoe, Misako; Inoue, Hidenari; Shirai, Tsuneo

doi:10.1021/ac00168a016

Cited by 82 publications

(45 citation statements)

References 20 publications

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“…In particular, apparently``twice-Nernstian'' responses of approximately 58 mVadecade for Ba 2 and Ca 2 -selective electrodes could be explained with an inverse relationship between a M (aq) and a M (org). Such unusual emf responses were experimentally obtained with ISE membranes containing anionic sites and acidic ionophores, the latter either in their protonated form or as 1 : 1 complexes with M 2 in their deprotonated form [149,151,152]. The changes in a M (org) that give rise to the apparently``non-Nernstian responses'' (Fig.…”

Section: Apparently``twice-nernstian'' Response Slopesmentioning

confidence: 78%

Polymer Membrane Ion-Selective Electrodes-What are the Limits?

Bakker¹,

Bühlmann²,

Pretsch³

1999

Electroanalysis

339

197

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This article reviews recent advances in the ®eld of potentiometric solvent polymeric membrane electrodes. These sensors have found widespread applications in a variety of ®elds, especially in the area of clinical diagnostics. Emphasis is given on the discussion of the theoretical and practical limits of ionophore-based ion-selective electrodes, with a special focus on electrode sensitivities, characterization of selectivities and dramatic improvements in detection limits. Advances in ionophore design and in the underlying model assumptions are also discussed. It is shown that a multitude of exciting new research possibilities have recently emerged in this well±established ®eld.

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Section: Apparently``twice-nernstian'' Response Slopesmentioning

confidence: 78%

Polymer Membrane Ion-Selective Electrodes-What are the Limits?

Bakker¹,

Bühlmann²,

Pretsch³

1999

Electroanalysis

339

197

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show abstract

“…On the other hand, lowering the primary ion activity in the sample causes elimination of the interfering ion from the membrane phase and leads to the observation of a lower detection limit for the primary ion. Only in a few circumstances do the primary and secondary ions co-exist in the membrane phase over a wide range of activities [27,29,30,39]. As discussed in the literature, these unusual cases may occur when the primary and interfering ion have different charges or form independent complexes of different stoichiometry.…”

Section: Discussionmentioning

confidence: 99%

Response Mechanism of Ion‐Selective Electrodes Based on a Guanidine Ionophore: An Apparently ‘Two‐Thirds Nernstian’ Response Slope

et al. 2008

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While ion-selective electrodes (ISEs) based on anion ionophores with guanidine groups were reported in the past, their response mechanism was poorly understood. In this study, an ionophore with one guanidine group was prepared as a model compound, and the chloride and sulfate responses of ISE membranes containing this ionophore were investigated. The electrodes exhibit Nernstian responses resulting from a neutral or charged ionophore mode when added cationic or anionic sites are used, respectively. Based on this observation, it might be expected that membranes without added ionic sites exhibit Nernstian responses according to a charged carrier mechanism. However, experimental results show an apparently two -thirds Nernstian equilibrium response, which can be explained on the basis of the phase boundary model.

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“…More limited data have furthermore shown that monensin displays some capacity to extract divalent cations from a bulk aqueous to a bulk organic phase (57) and to convey these cations through three phase bulk solvent systems (60) and polyvinyl chloride membranes in ion-selective electrodes (61,62). Thus, previous studies have suggested that monensin might not be strictly an ionophore for monovalent cations, but they did not reveal that it is actually a highly selective and efficient ionophore for Pb 2ϩ when phospholipid membranes are employed.…”

Section: Figmentioning

confidence: 99%

Monensin Mediates a Rapid and Selective Transport of Pb2+

Hamidinia¹,

Shimelis²,

Tan³

et al. 2002

Journal of Biological Chemistry

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The carboxylic acid ionophore monensin, known as an electroneutral Na ؉ ionophore, an anticoccidial agent, and a growth-promoting feed additive in agriculture, is shown to be highly efficient as an ionophore for Pb 2؉ and to be highly selective for Pb 2؉ compared with other divalent cations. Monensin transports Pb 2؉ by an electroneutral mechanism in which the complex PbMonOH is the transporting species. Electrogenic transport via the species PbMon ؉ may also be possible. Monensin catalyzed Pb 2؉ transport is little affected by Ca 2؉ , Mg 2؉ , or K ؉ concentrations that are encountered in living systems. Na ؉ is inhibitory, but its effectiveness at 100 mM does not exceed ϳ50%. The poor activity of monensin as an ionophore for divalent cations other than Pb 2؉ is consistent with the pattern of complex formation constants observed in the mixed solvent 80% methanol/water. This pattern also explains why Ca 2؉ , Mg 2؉ , and K ؉ are ineffective as inhibitors of Pb 2؉ transport, but it does not fully explain the actions of Na ؉ , where kinetic features of the transport mechanism may also be important. When given to rats at 100 ppm in feed together with Pb 2؉ at 100 ppm in drinking water, monensin reduces Pb accumulation in several organs and tissues. It also accelerates the excretion of Pb that was accumulated previously and produces this effect without depleting the organs of zinc or copper. Monensin, used alone or in combination with other agents, may be useful for the treatment of Pb intoxication.

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Ion-selective electrodes based on natural carboxylic polyether antibiotics

Cited by 82 publications

References 20 publications

Polymer Membrane Ion-Selective Electrodes-What are the Limits?

Polymer Membrane Ion-Selective Electrodes-What are the Limits?

Response Mechanism of Ion‐Selective Electrodes Based on a Guanidine Ionophore: An Apparently ‘Two‐Thirds Nernstian’ Response Slope

Monensin Mediates a Rapid and Selective Transport of Pb2+

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