Ion-responsive chitosan hydrogel actuator inspired by carrotwood seed pod

Zhu, Xinyi; Yang, Chen; Jian, Yinghao; Deng, Hongbing; Du, Yumin; Shi, Xiaowen

doi:10.1016/j.carbpol.2021.118759

Cited by 48 publications

(13 citation statements)

References 51 publications

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“…In addition, hydrogel actuators have also received extensive attention because they can change volume or shapes largely according to different physicochemical signals. , Li and Li et al reported a smart luminescent bilayer hydrogel actuator responsive to pH and temperature costimulation, which can achieve a dual response of shape change and luminescence . Wang and Sun et al proposed a fully temperature-driven bilayer hydrogel actuator to achieve rapid thermoresponsive bending, recovery ability, and a large bending angle .…”

Section: Introductionmentioning

confidence: 99%

Highly Adhesive, Stretchable, and Antifreezing Hydrogel with Excellent Mechanical Properties for Sensitive Motion Sensors and Temperature-/Humidity-Driven Actuators

Zhou

Yuan

2022

ACS Appl. Mater. Interfaces

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Conductive hydrogels as flexible wearable devices have attracted considerable attention due to their mechanical flexibility and intelligent sensing. How to endow more and better performance, such as high self-adhesion, stretchability, and wide application temperature range for traditional hydrogels and flexible sensors is a challenge. Herein, a stretchable, self-adhesive, and antifreezing conductive hydrogel with multiple networks and excellent mechanical properties was prepared by a two-step method for its application in sensitive motion sensors and temperature-/ humidity-driven actuators. First, quaternary chitosan (QCS) was introduced into the network of an acrylamide (AM) and 1-vinyl imidazole (VI) copolymer initiated by UV-photoinitiated radical polymerization. Then, the double-network hydrogel was immersed in a FeCl 3 solution to fabricate the P(AAm-co-VI)/QCS-Fe 3+ ionic hydrogel with multiple physical networks. The properties of the hydrogel were controllable and adjustable. The toughness of the ionic hydrogel could reach up to 654.4 kJ/m 3 , the fracture strength could reach 253.1 kPa, and the compressive strength reached 8.4 MPa at an 80% compression strain. The multiple physical networks improved the mechanical properties and the quick resilience of the hydrogel. A large amount of FeCl 3 in the network greatly enhanced the ionic conductivity. Meanwhile, hydrogen bonds with water molecules inhibit the formation of ice crystals between zero water molecules and enhance the freezing resistance of P(Aam-co-VI)/QCS hydrogels. The active group on the QCS chain provided adhesiveness to various substrates for hydrogels. The P(AAm-co-VI)/QCS-Fe 3+ hydrogel-based sensor showed high sensitivity, which can detect human movement and pulse, with a gauge factor of 2.37. Finally, due to the different dehydration rates of the P(AAm-co-VI)/QCS-Fe 3+ and P(AAm-co-VI)/QCS hydrogel, a double-layer temperature/humidity-driven actuator was fabricated, expanding the application of conductive hydrogels.

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Section: Introductionmentioning

confidence: 99%

Highly Adhesive, Stretchable, and Antifreezing Hydrogel with Excellent Mechanical Properties for Sensitive Motion Sensors and Temperature-/Humidity-Driven Actuators

Zhou

Yuan

2022

ACS Appl. Mater. Interfaces

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“…Hydrogels are versatile in their applications in different fields like industry, [60] removal of metal ions, [61,62] absorption of dyes, [63] controlled released devices in agriculture, [64] diaper industry, [65] biosensors, [66] growth nurseries, [67] water proofing, [68] solar steam generation, [69] 3D printing, [70] permeable membranes, [71] and hygiene products. [72] In biomedical field, hydrogels are employed in drug delivery, [73] wound dressing, [74] actuator, [75] contact lenses, [76] artificial blood vessels, [77] immuno-modulation, [78] cell encapsulation, [79] surgical adhesives, [80] regenerative medicines, [81] and wound healing applications. [82][83][84] In tissue engineering, hydrogels are used as filling agent, support for cells and helper in ideal tissue formation.…”

Section: Applications Of Hydrogelsmentioning

confidence: 99%

Chitosan and Carrageenan‐Based Biocompatible Hydrogel Platforms for Cosmeceutical, Drug Delivery, and Biomedical Applications

et al. 2022

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Hydrogels are three‐dimensional water hungry networks that are currently the focus of intense scientific investigations owing to their potential applications in biomedicine, pharmaceuticals, biotechnology, biosensing, agriculture and cosmetics. Traditional hydrogels are incorporated with toxic cross‐linkers, lower drug loading and are shorter in load bearing capacity. Hydrogels demonstrate significant physiochemical modification in reaction to minor fluctuations in surrounding medium. Therefore, diverse cross‐linkers, polymer blending, modification in polymers/cross‐linkers and addition of reinforcement approaches are used. This review offers a comprehensive overview of application prospects of chitosan and carrageenan‐based hydrogel materials in biomedical sector. Initially, properties of hydrogels, their types, impact of natural‐synthetic polymer blending, requirement of filler and applications of hydrogels are summarized. Afterward, the applications of chitosan and carrageenan hydrogel platforms for drug delivery, tissue engineering, cosmetics, dentistry and ophthalmic treatment are thoroughly vetted. In conclusion, the extraordinary biocompatible, biodegradable and non‐toxic features of chitosan and carrageenan‐based hydrogel systems promote their applicability in biomedical fields.

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“…Stimuli-responsive polymer thin films with engineered matrix characteristics can accomplish desirable shape-changing properties in response to external stimuli. The responsive actuation could be done via physical stimuli such as light, − temperature, − electricity, − and magnetic field or chemical stimuli like solvent-responsive, − pH-responsive, − and ionic strength responsive. The actuation of a solvent-responsive polymer is driven by the diffusion of solvent inside the polymer matrix.…”

Section: Introductionmentioning

confidence: 99%

Engineering the Nonmorphing Point of Actuation for Controlled Drug Release by Hydrogel Bilayer across the pH Spectrum

Kumar

Rajamanickam

Hazra

et al. 2022

ACS Appl. Mater. Interfaces

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Hydrogel-based pH-responsive bilayer actuators exhibit bidirectional actuation due to the differences in the concentration gradient developed across the thickness, the volume expansion due to swelling, and the mechanical stiffness of the layers involved. At a pH value (point), where the sum of these factors generates moments of equal magnitudes, the moments cancel each other and result in no net actuation. This pH point is termed here as a “nonmorphing point”. In this work, we present a bilayer of chitosan (CS) and carboxymethyl cellulose (CMC) cross-linked with citric acid (CA) with tunable nonmorphing points across the pH spectrum by modulating the concentration and cross-linking density of the layers involved. The standard CS/CMC bilayer films took about 40 s to completely fold (clockwise) in 0.1 M HCl and 78 s to completely fold (anticlockwise) in 0.1 M NaOH. Generally, pH-responsive actuators are designed for targeted drug delivery to a specific site inside the body as they show bidirectional (clockwise/anticlockwise) actuation around a single nonmorphing point. The same pH-responsive system cannot be applied for drug release at another site with a different functioning pH. Thus, having a pH-responsive system with multiple nonmorphing points is highly desirable. Drug release experiments were performed with FITC and EtBr as model drugs loaded in CS and CMC layers. Moreover, the clockwise/anticlockwise actuation of the bilayer around the nonmorphing point can facilitate or inhibit the release of a drug. The clockwise actuation resulted in 55% FITC release and inhibited EtBr release to 4%; anticlockwise actuation resulted in 50% EtBr release and inhibited FITC release to 5%. We demonstrated morphing induced drug release by hydrogel bilayer films with tunable nonmorphing points across the pH spectrum.

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Ion-responsive chitosan hydrogel actuator inspired by carrotwood seed pod

Cited by 48 publications

References 51 publications

Highly Adhesive, Stretchable, and Antifreezing Hydrogel with Excellent Mechanical Properties for Sensitive Motion Sensors and Temperature-/Humidity-Driven Actuators

Highly Adhesive, Stretchable, and Antifreezing Hydrogel with Excellent Mechanical Properties for Sensitive Motion Sensors and Temperature-/Humidity-Driven Actuators

Chitosan and Carrageenan‐Based Biocompatible Hydrogel Platforms for Cosmeceutical, Drug Delivery, and Biomedical Applications

Engineering the Nonmorphing Point of Actuation for Controlled Drug Release by Hydrogel Bilayer across the pH Spectrum

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