Ion Release Behavior of Silicophosphate Glasses Containing Six-Fold Coordinated Silicon Structure

Abstract

To facilitate the efficient use of phosphate-based glasses in various biomedical applications, it is essential to understand the effects of ion-releasing in the living body. In this work, the ion-releasing behavior of silicophosphate glass, designed as a supply source of silicate and phosphate ions that are effective for bone formation, was investigated. Two types of P 2 O 5 -SiO 2 -CaO-Na 2 O glasses containing 45-50 mol% of P 2 O 5 with both four-and six-fold coordinated silicon structures were prepared. The glass with ~50 mol% of P 2 O 5 content had a higher proportion of six-fold coordinated silicon structure, and it showed a lower ionic release to a simulated body fluid than that with ~45 mol% P 2 O 5 content. The release of the therapeutic ions from the silicophosphate glass can be effectively controlled by choosing their composition.

Structure and dissolution of silicophosphate glass

“…7 In our previous study, we found that in P 2 O 5 -SiO 2 -Na 2 O-CaO glasses with high P 2 O 5 content, ion dissolution is improved in an ultraphosphate glass with high [6] Si content. 8 We reported the ions release behavior for two types of [6] Si-containing glasses with the P 2 O 5 content of 45 and 50 mol%, xed SiO 2 /Na 2 O/CaO ratios. The glass with high P 2 O 5 content controlled the ion release amounts effectively.…”