Ion Mobility-Tandem Mass Spectrometry of Mucin-type O-Glycans
Kevin Pagel,
Leïla Bechtella,
Jin Chunsheng
et al.
Abstract:The dense O-glycosylation of mucins plays an important role in the defensive properties of the mucus hydrogel. Aberrant glycosylation is often correlated with inflammation and pathology such as COPD, cancer, and Crohn’s disease. The inherent complexity of glycans and the diversity in the O-core structure constitute fundamental challenges for the analysis of mucin-type O-glycans. Due to coexistence of multiple isomers, multidimensional workflows such as LC-MS are required. To separate the highly polar carbohydr… Show more
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