Ion mobility spectrometry in scientific literature and in the International Journal for Ion Mobility Spectrometry (1998–2007)

Baumbach, Jan

doi:10.1007/s12127-008-0009-2

Cited by 15 publications

(6 citation statements)

References 22 publications

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“…Freeware are available allowing conversion of many proprietary data formats to those open formats. For a non-MS detector, the most common are JCAMP.dx [49] and netCDS [50], for MS detector the mzML [51] format is now widely accepted. It should be also emphasized that having access to the numeric values, general data analysis packages such as Excel, Matlab, Python or R can be used to tailor the data analysis.…”

Section: Data Analysis Softwarementioning

confidence: 99%

Open source capillary electrophoresis

2018

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Open source paradigm is becoming widely accepted in scientific communities and open source hardware is finding its steady place in chemistry research. In this review article, we provide the reader with the most up-to-date information on open source hardware and software resources enabling the construction and utilization of an "open source capillary electrophoresis instrument". While CE is still underused as a separation technique, it offers unique flexibility, low-cost, and high efficiency and is particularly suitable for open source instrumental development. We overview the major parts of CE instruments, such as high voltage power supplies, detectors, data acquisition systems, and CE software resources with emphasis on availability of the open source information on the web and in the scientific literature. This review is the first of its kind, revealing accessible blueprints of most parts from which a fully functional open source CE system can be built. By collecting the extensive information on open source capillary electrophoresis in this review article, the authors aim at facilitating the dissemination of knowledge on CE within and outside the scientific community, fosters innovation and inspire other researchers to improve the shared CE blueprints.

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Section: Data Analysis Softwarementioning

confidence: 99%

Open source capillary electrophoresis

2018

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“…Ion mobility has recently also been proved in the analysis of biological materials (proteomics and metabolomics [33,34]) and for pharmaceutical applications, for example, cleaning validations.…”

Section: Ion Mobility Spectroscopy (Ims)mentioning

confidence: 99%

Trends in Spectroscopic Techniques for Process Control

Maiwald

Gornushkin

Ostermann

2014

Handbook of Spectroscopy

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“…Ion mobility spectrometers (IMS) provide high sensitivity (detection limits down to the picogram per litre and parts per trillion by volume range) combined with relatively low technical expenditure and high-speed data acquisition. MCC-IMS are increasingly in demand for medical diagnosis, therapy and medication control via breath analyses [5–7], as well as additional biological applications [8–10] and process control [11–13]. Using MCC–IMS directly for clinical diagnosis allows results to be obtained in minutes, and it provides additional information that can be used to determine the therapeutic strategy.…”

Section: Introductionmentioning

confidence: 99%

Alignment of retention time obtained from multicapillary column gas chromatography used for VOC analysis with ion mobility spectrometry

et al. 2010

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Multicapillary column (MCC) ion mobility spectrometers (IMS) are increasingly in demand for medical diagnosis, biological applications and process control. In a MCC-IMS, volatile compounds are differentiated by specific retention time and ion mobility when rapid preseparation techniques are applied, e.g. for the analysis of complex and humid samples. Therefore, high accuracy in the determination of both parameters is required for reliable identification of the signals. The retention time in the MCC is the subject of the present investigation because, for such columns, small deviations in temperature and flow velocity may cause significant changes in retention time. Therefore, a universal correction procedure would be a helpful tool to increase the accuracy of the data obtained from a gas-chromatographic preseparation. Although the effect of the carrier gas flow velocity and temperature on retention time is not linear, it could be demonstrated that a linear alignment can compensate for the changes in retention time due to common minor deviations of both the carrier gas flow velocity and the column temperature around the MCC-IMS standard operation conditions. Therefore, an effective linear alignment procedure for the correction of those deviations has been developed from the analyses of defined gas mixtures under various experimental conditions. This procedure was then applied to data sets generated from real breath analyses obtained in clinical studies using different instruments at different measuring sites for validation. The variation in the retention time of known signals, especially for compounds with higher retention times, was significantly improved. The alignment of the retention time—an indispensable procedure to achieve a more precise identification of analytes—using the proposed method reduces the random error caused by small accidental deviations in column temperature and flow velocity significantly.

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Ion mobility spectrometry in scientific literature and in the International Journal for Ion Mobility Spectrometry (1998–2007)

Cited by 15 publications

References 22 publications

Open source capillary electrophoresis

Open source capillary electrophoresis

Trends in Spectroscopic Techniques for Process Control

Alignment of retention time obtained from multicapillary column gas chromatography used for VOC analysis with ion mobility spectrometry

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