Ion Mobility Spectrometry as a Detector for Molecular Imprinted Polymer Separation and Metronidazole Determination in Pharmaceutical and Human Serum Samples

Jafari, Mohammad T.; Rezaei, Behzad; Zaker, B.

doi:10.1021/ac802557t

Cited by 74 publications

(36 citation statements)

References 53 publications

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“…It is well known that pH plays an important role in adsorption performance of the imprinted polymer toward different ions [30]. The effect of pH on the adsorption of Fe 3 O 4 @SiO 2 @IIP toward Pb(II) was studied with varying the pH from 4.0 to 9.0 and the results were presented in Fig.…”

Section: Effect Of Ph On the Adsorption Of Pb(ii)mentioning

confidence: 99%

Preparation of core–shell magnetic ion-imprinted polymer for selective extraction of Pb(II) from environmental samples

Zhang

Liu

et al. 2011

Chemical Engineering Journal

134

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a b s t r a c tA novel magnetic ion-imprinted polymer (Fe 3 O 4 @SiO 2 @IIP) was synthesized by using 3-(2-aminoethylamino)propyltrimethoxysilane (AAPTS) as the functional monomer, tetraethylorthosilicate (TEOS) as the cross-linker and Pb(II) as the template and evaluated for selective extraction of Pb(II) from environmental sample by magnetic solid phase extraction (M-SPE) procedure. The factors affecting separation and preconcentration of the target heavy metals involving pH, eluting solvent and sample volume were studied in detail. Under the optimized experimental conditions, the kinetics adsorption and adsorption capacity of the Fe 3 O 4 @SiO 2 @IIP toward Pb(II) were estimated. The results indicated that the adsorption mechanism is corresponding with the second-order adsorption process with correlation coefficient (r 2 = 0.990), and the maximum adsorption capacity is 19.61 mg g −1 . The relative selectivity factor (ˇ) values of Pb(II)/Cu(II), Pb(II)/Zn(II), Pb(II)/Cd(II) and Pb(II)/Hg(II) are 7. 41, 6.76, 3.75 and 6.39, respectively. The Fe 3 O 4 @SiO 2 @IIP was applied for extracting and detecting of Pb(II) in real environmental samples combined with atomic adsorption spectrometer successfully with high recoveries of 98.0%.

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Section: Effect Of Ph On the Adsorption Of Pb(ii)mentioning

confidence: 99%

Preparation of core–shell magnetic ion-imprinted polymer for selective extraction of Pb(II) from environmental samples

Zhang

Liu

et al. 2011

Chemical Engineering Journal

134

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“…These polymers show a certain chemical affinity for the original molecule and can be used to fabricate sensors [44], for preconcentration or for separation methods [45]. In this way, very different modifications were done on the MIP structure to achieve more selectivity in manipulation of reaction, such as conductivity increasing to electrochemical application [48].…”

Section: Discussionmentioning

confidence: 99%

Nanoscale Manipulation of Prednisolone as Electroactive Configuration Using Molecularly Imprinted‐Multiwalled Carbon Nanotube Paste Electrode

Rezaei

Mirahmadi-Zare

2011

Electroanalysis

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Prednisolone has no suitable configuration for electroactivation in the potential window from À1.2 to + 1.5 V. In this paper, a new catalytic application of molecularly imprinted polymers (MIP) was employed to achieve a suitable prednisolone conformation for electrochemical oxidation. Also, MIP as a recognition element improved the selectivity of the sensor for determination of prednisolone. In addition, to improve the sensitivity of the electrode multiwalled carbon nanotubes (MWCNT) were used in the preparation of MIP. Using differential pulse voltammetry (DPV) under optimized conditions, the calibration curve showed a linear dynamic range (0.08-160.00 mM) with a detection limit of 0.05 mM (S/N = 3). The modified electrode was successfully applied as prednisolone sensor in real samples such as plasma, urine and pharmaceutical formulation.

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“…Different electrodes such as activated GCE [31], MWCNTs/GCE [32], DNA-modified GCE [33,34], hanging mercury drop electrode (HDME) [35] and molecularly imprinted polymer-carbon paste electrode have been used inMTZ electrochemical assays [36,37]. In the present study, the electrochemical behaviour of MTZ and the effects of some experimental variables on the electro reduction of this drug have been investigated on a GR-TiO2 modified GCE by cyclic voltammetry and differential pulse voltammetry techniques.…”

Section: Methodsmentioning

confidence: 99%

Sensitive determination of metronidazole based on Graphene-TiO2 modified glassy carbon electrode in human serum and urine samples

et al. 2015

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In the present work, a new Graphene-TiO2 (GR-TiO2) modified glassy carbon electrode (GCE) is suggested for sensitive electrochemical determination of metronidazole (MTZ). Electrochemical studies revealed that GR-TiO2 nanoparticles increased the efficiency of electron transfer kinetics by increasing the available surface area of the electrode and charge mobility between MTZ and GR-TiO2 modified electrode. Compared to bare GCE, the modified electrode greatly enhanced the reduction signal of MTZ. The electrochemical behaviour of the modified electrode and the electrochemical reduction of MTZ were investigated with electrochemical impedance spectroscopy, cyclic voltammetry and differential pulse voltammetry techniques. The charge transfer coefficient (α) was calculated to be 0.694. Under optimized conditions, the linear concentration range and detection limit of MTZ were 5.0×10 -7 to 2.5×10 -5 M -1 and 5.4×10 -8 (S/N = 3), respectively. Finally, this sensing method was successfully applied for the determination of MTZ in human blood serum and urine samples.

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Ion Mobility Spectrometry as a Detector for Molecular Imprinted Polymer Separation and Metronidazole Determination in Pharmaceutical and Human Serum Samples

Cited by 74 publications

References 53 publications

Preparation of core–shell magnetic ion-imprinted polymer for selective extraction of Pb(II) from environmental samples

Preparation of core–shell magnetic ion-imprinted polymer for selective extraction of Pb(II) from environmental samples

Nanoscale Manipulation of Prednisolone as Electroactive Configuration Using Molecularly Imprinted‐Multiwalled Carbon Nanotube Paste Electrode

Sensitive determination of metronidazole based on Graphene-TiO2 modified glassy carbon electrode in human serum and urine samples

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