Ion Mobility Spectrometry and Its Applications in Detection of Chemical Warfare Agents

Mäkinen, Marko; Anttalainen, Osmo; Sillanpää, Mika

doi:10.1021/ac100931n

Cited by 242 publications

(148 citation statements)

References 52 publications

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“…Due to the absence of an external gas supply, the system utilizes air as collision gas for MS 2 experiments. For MS 2 , a precursor ion isolation is performed first by applying a modulated rf to the trapped ions. Then the isolated species are fragmented by excitation and collision with remaining air molecules.…”

Section: Ms Instrumentationmentioning

confidence: 99%

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Direct and Sensitive Detection of CWA Simulants by Active Capillary Plasma Ionization Coupled to a Handheld Ion Trap Mass Spectrometer

Wolf

Etter

Schaer

et al. 2016

J. Am. Soc. Mass Spectrom.

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Abstract. An active capillary plasma ionization (ACI) source was coupled to a handheld mass spectrometer (Mini 10.5; Aston Labs, West Lafayette, IN, USA) and applied to the direct gas-phase detection and quantification of chemical warfare agent (CWA) related chemicals. Complementing the discontinuous atmospheric pressure interface (DAPI) of the Mini 10.5 mass spectrometer with an additional membrane pump, a quasi-continuous sample introduction through the ACI source was achieved. Nerve agent simulants (three dialkyl alkylphosphonates, a dialkyl phosporamidate, and the pesticide dichlorvos) were detected at low gas-phase concentrations with limits of detection ranging from 1.0 μg/m 3 to 6.3 μg/m 3 . Our results demonstrate a sensitivity enhancement for portable MS-instrumentation by using an ACI source, enabling direct, quantitative measurements of volatile organic compounds. Due to its high sensitivity, selectivity, low power consumption (<80 W) and weight (<13 kg), this instrumentation has the potential for direct on-site CWA detection as required by military or civil protection.

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Section: Ms Instrumentationmentioning

confidence: 99%

“…One central aspect of CWA detection research is the development of handheld and therefore field deployable detection systems. Currently, ion mobility spectrometry (IMS) is the most common technology in this context [2]. Until now, IMS holds most promise for fast screenings and is thus ideal for early warning systems.…”

Section: Introductionmentioning

confidence: 99%

Direct and Sensitive Detection of CWA Simulants by Active Capillary Plasma Ionization Coupled to a Handheld Ion Trap Mass Spectrometer

Wolf

Etter

Schaer

et al. 2016

J. Am. Soc. Mass Spectrom.

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show abstract

“…The choice of materials was also due to the possibility of their registration and subsequent identification as a positive or in a negative mode at the same time [12,[14][15][16][17]. During the test analytes (in liquid phase) were deposited on the surface of tissues made of aluminum foil using microsyringe.…”

Section: Resultsmentioning

confidence: 99%

Ion Mobility Spectrometer for Rapid Simultaneous Detection of Positive and Negative Ions

Vasilyev

Першенков

Belyakov

et al. 2016

3rd International Conference on Nanotechnologies and Biomedical Engineering

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Abstract-Ion Mobility Spectrometry (IMS) is a common technology used for rapid detection of trace amounts of explosives (mostly forming negative ions) and drugs (forming positive ions). Emergency chemically hazardous substances widely used in modern industry. Some emergency chemically hazardous substances form positive ions, others form negative ions. Therefore, for the detection of different substances in real time is required to apply the structure of two IMS-detectors. The article describes a device for the simultaneous detection of ions of both polarities with the ionization source based on a pulsed corona discharge. Authors investigated the advantages and disadvantages of such construction compared to unipolar cell in terms of sensitivity. Experimental results have demonstrated.

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“…4) In the dri tube method of the original IMS, a pulse of ion swarm is injected into a gas cell (ion dri tube, ion dri cell) in which an electrostatic eld, E, is applied and bu er gas is admitted. e injected ions reach a constant dri velocity, v d , which is determined by the balance of acceleration with the electric eld and the deceleration by collisions with the bu er gas atoms.…”

Section: Introductionmentioning

confidence: 99%

Application of Ion Mobility-Mass Spectrometry to the Study of Ionic Clusters

et al. 2014

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Stable cluster sizes and compositions have been investigated for cations and anions of ionic bond clusters such as alkali halides and transition metal oxides by ion mobility-mass spectrometry (IM-MS). Usually structural information of ions can be obtained from collision cross sections determined in IM-MS. In addition, we have found that stable ion sizes or compositions were predominantly produced in a total ion mass spectrum, which was constructed from the IM-MS measurement. ese stable species were produced as a result of collision induced dissociations of the ions in a dri cell. We have con rmed this result in the sodium uoride cluster ions, in which cuboid magic number cluster ions were predominantly observed. Next the stable compositions, which were obtained for the oxide systems of the rst row transition metals, Ti, Fe, and Co, are characteristic for each of the metal oxide cluster ions.

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Ion Mobility Spectrometry and Its Applications in Detection of Chemical Warfare Agents

Cited by 242 publications

References 52 publications

Direct and Sensitive Detection of CWA Simulants by Active Capillary Plasma Ionization Coupled to a Handheld Ion Trap Mass Spectrometer

Direct and Sensitive Detection of CWA Simulants by Active Capillary Plasma Ionization Coupled to a Handheld Ion Trap Mass Spectrometer

Ion Mobility Spectrometer for Rapid Simultaneous Detection of Positive and Negative Ions

Application of Ion Mobility-Mass Spectrometry to the Study of Ionic Clusters

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