Ion Mobility in Clinical Analysis: Current Progress and Future Perspectives

Chouinard, Christopher D.; Wei, Michael S.; Beekman, Christopher R.; Kemperman, Robin H. J.; Yost, Richard A.

doi:10.1373/clinchem.2015.238840

Cited by 93 publications

(65 citation statements)

References 70 publications

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“…for analyte adduct formation would be interesting to investigate as another potential separation strategy, as it would require very little sample preparation in comparison to LC derivatization methodologies. 73 …”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

Portable FAIMS: Applications and future perspectives

Costanzo¹,

Boock²,

Kemperman

et al. 2017

International Journal of Mass Spectrometry

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Miniaturized mass spectrometry (MMS) is optimal for a wide variety of applications that benefit from field-portable instrumentation. Like MMS, field asymmetric ion mobility spectrometry (FAIMS) has proven capable of providing in situ analysis, allowing researchers to bring the lab to the sample. FAIMS compliments MMS very well, but has the added benefit of operating at atmospheric pressure, unlike MS. This distinct advantage makes FAIMS uniquely suited for portability. Since its inception, FAIMS has been envisioned as a field-portable device, as it affords less expense and greater simplicity than many similar methods. Ideally, these are simple, robust devices that may be operated by non-professional personnel, yet still provide adequate data when in the field. While reducing the size and complexity tends to bring with it a loss of performance and accuracy, this is made up for by the incredibly high throughput and overall convenience of the instrument. Moreover, the FAIMS device used in the field can be brought back to the lab, and coupled to a conventional mass spectrometer to provide any necessary method development and compound validation. This work discusses the various considerations, uses, and applications for portable FAIMS instrumentation, and how the future of each applicable field may benefit from the development and acceptance of such a device.

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Section: Summary and Future Perspectivesmentioning

confidence: 99%

Portable FAIMS: Applications and future perspectives

Costanzo¹,

Boock²,

Kemperman

et al. 2017

International Journal of Mass Spectrometry

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show abstract

“…This involves the movement of gas-phase ions that are exposed to an electric field in a drift tube, where they counteract with a drift gas (nitrogen or synthetic air). The product ions gain a constant velocity through the influence of an electrical field and by collision with the drift gas molecules [ 59 ]. This velocity depends on the size, mass and shape of the concerning product ions.…”

Section: Introductionmentioning

confidence: 99%

Biomarkers for early diagnosis of malignant mesothelioma: Do we need another moonshot?

et al. 2017

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Early diagnosis of malignant pleural mesothelioma (MPM) is a challenge for clinicians. The disease is usually detected in an advanced stage which precludes curative treatment. We assume that only new and non-invasive biomarkers allowing earlier detection will result in better patient management and outcome. Many efforts have already been made to find suitable biomarkers in blood and pleural effusions, but have not yet resulted in a valid and reproducible diagnostic one. In this review, we will highlight the strengths and shortcomings of blood and fluid based biomarkers and highlight the potential of breath analysis as a non-invasive screening tool for MPM. This method seems very promising in the early detection of diverse malignancies, because exhaled breath contains valuable information on cell and tissue metabolism. Research that focuses on breath biomarkers in MPM is in its early days, but the few studies that have been performed show promising results. We believe a breathomics-based biomarker approach should be further explored to improve the follow-up and management of asbestos exposed individuals.

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“…8,9 This recent and unprecedented commercial accessibility of IM-MS in combination with existing liquid chromatography and tandem MS functionality has provided powerful multidimensional separation capabilities to the greater research community, 10–13 which in turn has broadened the scope of applications and fields in which IM-MS is now making a significant impact. 14–19 Many of the contemporary challenges being addressed by IM-MS are grand challenges of our era of humanity. 11 …”

mentioning

confidence: 99%

Ion Mobility Collision Cross Section Compendium

2016

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In this review, we focus on an important aspect of ion mobility (IM) research, namely the reporting of quantitative ion mobility measurements in the form of the gas-phase collision cross section (CCS), which has provided a common basis for comparison across different instrument platforms and offers a unique form of structural information, namely size and shape preferences of analytes in the absence of bulk solvent. This review surveys the over 24,000 CCS values reported from IM methods spanning the era between 1975 to 2015, which provides both a historical and analytical context for the contributions made thus far, as well as insight into the future directions that quantitative ion mobility measurements will have in the analytical sciences. The analysis was conducted in 2016, so CCS values reported in that year are purposely omitted. In another few years, a review of this scope will be intractable, as the number of CCS values which will be reported in the next three to five years is expected to exceed the total amount currently published in the literature.

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Ion Mobility in Clinical Analysis: Current Progress and Future Perspectives

Cited by 93 publications

References 70 publications

Portable FAIMS: Applications and future perspectives

Portable FAIMS: Applications and future perspectives

Biomarkers for early diagnosis of malignant mesothelioma: Do we need another moonshot?

Ion Mobility Collision Cross Section Compendium

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