Ion induced fragmentation cross-sections of DNA constituents

Rudek, Benedikt; Arndt, Anselm; Bennett, Daniel; Wang, Mingjie; Rabus, Hans

doi:10.1140/epjd/e2015-60204-7

Cited by 7 publications

(3 citation statements)

References 45 publications

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“…A literature survey reveals inconstencies concerning the peak at 55 u because the peak was not reported in each electron ionization study with isolated THF. Fuss et al [ 20 ], Dampc et al [ 31 ], and Ren et al [ 43 ] were able to detect it, whereas Gallegos and Kiser [ 32 ], Rudeck et al [ 44 ], and Collin and Conde-Caprace [ 33 ], a well as the NIST database [ 45 ] do not mention it. Dampc et al [ 31 ] assigned this peak to impurities of the sample since the intensity decreased with time of the measurements.…”

Section: Resultsmentioning

confidence: 99%

Study of Electron Ionization and Fragmentation of Non-hydrated and Hydrated Tetrahydrofuran Clusters

Neustetter

Mahmoodi-Darian

Denifl

2017

J. Am. Soc. Mass Spectrom.

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Mass spectroscopic investigations on tetrahydrofuran (THF, C4H8O), a common model molecule of the DNA-backbone, have been carried out. We irradiated isolated THF and (hydrated) THF clusters with low energy electrons (electron energy ~70 eV) in order to study electron ionization and ionic fragmentation. For elucidation of fragmentation pathways, deuterated TDF (C4D8O) was investigated as well. One major observation is that the cluster environment shows overall a protective behavior on THF. However, also new fragmentation channels open in the cluster. In this context, we were able to solve a discrepancy in the literature about the fragment ion peak at mass 55 u in the electron ionization mass spectrum of THF. We ascribe this ion yield to the fragmentation of ionized THF clusters. Graphical Abstractᅟ

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Section: Resultsmentioning

confidence: 99%

Study of Electron Ionization and Fragmentation of Non-hydrated and Hydrated Tetrahydrofuran Clusters

Neustetter

Mahmoodi-Darian

Denifl

2017

J. Am. Soc. Mass Spectrom.

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“…Also due to the size and di culty of isolation, measurements are currently limited with respect to biological molecules in their native (aqueous) environment. Currently most of our understanding comes from studies in the gas phase, where the e↵ects of proton and other ion collisions on small molecules have been investigated [5,8,[33][34][35][36][37][38][39][40][41]. The resulting fragments can then be used to determine the most common fragmentation channels for a given particle energy.…”

Section: Introductionmentioning

confidence: 99%

Time-dependent density-functional-theory investigation of the collisions of protons and α particles with uracil and adenine

et al. 2017

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Time-dependent density functional theory was employed to study the e↵ects of proton and ↵-particle radiation on uracil and adenine. This method has the advantage of treating nuclear motion and electronic motion simultaneously, allowing for the study of electronic excitation, charge transfer, ionization, and nuclear motion. Particle energies were surveyed in the range of 15-500 keV for protons and 100-2000 keV for ↵-particles in conjunction with impact points both on and o↵ carbon bonds in order to investigate the electron and nuclear dynamics of irradiated molecules and the form and quantity of transferred energy. The stopping power, energy transferred, and ionization were found and the relationship between incident particle energy and electron density of to the target molecule was characterized for proton and ↵-particle radiation incident on adenine and uracil.

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“…The paper of Piatnytskyi et al [34] studies the action of hydrogen peroxide on DNA. Rudek et al [35] report experimental studies of DNA constituents fragmentation on proton impact. Kumar et al [36] compare and discuss experimental studies of DNA irradiated with electrons.…”

Section: Introductionmentioning

confidence: 99%

Nano-scale processes behind ion-beam cancer therapy

et al. 2016

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Abstract. This topical issue collates a series of papers based on new data reported at the third Nano-IBCT Conference of the COST Action MP1002: Nanoscale Insights into Ion Beam Cancer Therapy, held in Boppard, Germany, from October 27th to October 31st, 2014. The Nano-IBCT COST Action was launched in December 2010 and brought together more than 300 experts from different disciplines (physics, chemistry, biology) with specialists in radiation damage of biological matter from hadron-therapy centres, and medical institutions. This meeting followed the first and the second conferences of the Action held in October 2011 in Caen, France and in May 2013 in Sopot, Poland respectively. This conference series provided a focus for the European research community and has highlighted the pioneering research into the fundamental processes underpinning ion beam cancer therapy.

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Ion induced fragmentation cross-sections of DNA constituents

Cited by 7 publications

References 45 publications

Study of Electron Ionization and Fragmentation of Non-hydrated and Hydrated Tetrahydrofuran Clusters

Study of Electron Ionization and Fragmentation of Non-hydrated and Hydrated Tetrahydrofuran Clusters

Time-dependent density-functional-theory investigation of the collisions of protons and α particles with uracil and adenine

Nano-scale processes behind ion-beam cancer therapy

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