Ion-Exchange Chromatography of Amino Acids in Ejaculates of Diabetics

Kaemmerer, Harald; Mitzkat, H. J.

doi:10.1111/j.1439-0272.1985.tb01046.x

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…Garlic extract protects DNA from the damages caused by free radicals and cyclophosphamide metabolites. In case the DNA of the testes cells is damaged due to cyclophosphamide metabolites, the garlic compounds recover them [11,13,14]. Using the results of Table 1 and Figure 1, we can conclude that by consumption of cyclophosphamide in the experimental group IV, LH hormone shows a significant reduction as compared with the control group.…”

Section: Discussionmentioning

confidence: 59%

The Effect of Hydro-Alcoholic Allium sativum Extract on Sexual Hormones in Mature Male Rats Under Chemotherapy With Cyclophosphamide

Mirfardi

Johari

2015

Zahedan J Res Med Sci

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Section: Discussionmentioning

confidence: 59%

The Effect of Hydro-Alcoholic Allium sativum Extract on Sexual Hormones in Mature Male Rats Under Chemotherapy With Cyclophosphamide

Mirfardi

Johari

2015

Zahedan J Res Med Sci

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“…Semen pH was slightly decreased in diabetic untreated rats. DM is a metabolic disease that has been shown to be associated with high concentration of certain amino acids and their derivatives in the seminal fluid, believed to be the result of defective kreb's cycle (Kaemmerer and Mitzkat, 1985). This is likely how semen pH is decreased.…”

Section: Discussionmentioning

confidence: 99%

“…This is likely how semen pH is decreased. This could also be implicated in the impairment of sperm motility and formation of defective sperm cells (Kaemmerer and Mitzkat, 1985). With either insulin or zinc treatment, semen pH was increased.…”

Section: Discussionmentioning

confidence: 99%

Insulin and Zinc Co-Administration Ameliorate Diabetes Mellitus-Induced Reproductive Dysfunction in Male Rats

Ujah

2022

NJPS

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Impaired male reproductive function is a major complication associated with diabetes mellitus (DM). Whether or not insulin, when co-administered with zinc will reverse or ameliorate reproductive dysfunction in male diabetics is not known. This study thus sought to establish if co-administration of insulin and zinc reverses or ameliorates male reproductive dysfunction in DM better than either insulin or zinc. Five (5) normal and twenty (20) diabetic sexually mature rats were assigned into five groups of five animals each. Group A consisted of normal rats and had access to only food and water. Group B consisted of diabetic animals with no treatment and served as DM control. Groups C and D consisted of diabetic animals and received insulin and zinc respectively. Group E consisted of diabetic animals and received both insulin and zinc. All diabetic animals had free access to food and water. Insulin in all cases was given subcutaneously twice daily in the morning and evening at 1 unit and 4 units respectively. Zinc (10mg/kg) was given orally once daily. Treatments in all cases commenced two weeks after DM was confirmed. The treatment lasted ten days. Samples were thereafter collected for analyses. DM decreased sperm count, sperm motility, sperm viability, normal sperm cells, semen pH, serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone, while increasing sperm cells with defective tails. DM also impaired testicular morphology. Insulin and zinc co-administration improved sperm viability, sertoli cell count, Johnsen’s score, serum FSH, LH and testosterone. Co-administration also improved semen pH towards normal. Insulin or zinc ameliorated several aspects of DM-induced male sexual dysfunction. However, the co-administration of insulin and zinc provided better results.

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Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and streptozotocin-treated rat models for diabetes

et al. 2006

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Diabetes mellitus is a degenerative disease that has deleterious effects on male reproductive function, possibly through an increase in oxidative stress. This study was conducted in order to clarify the mechanisms by which oxidative stress influences animal models for both type 1 (streptozotocin-treated rats, STZ) and type 2 (Goto-Kakizaki (GK) rats) diabetes. We determined the extent of lipid peroxidation, protein oxidation, lactate levels, adenine nucleotides, adenylate energy charge and the activity of glutathione peroxidase, glutathione reductase and lactate dehydrogenase, in isolated testicular cells of control and diabetic rats. We have also correlated these parameters with sperm count and motility. Sperm concentration and motility were decreased in STZ-treated rats. ATP levels were lower in rats treated with STZ for 3 months, in contrast to GK and rats treated with STZ for 1 month, suggesting an adaptative response. STZ-treated rats showed increased lipid peroxidation after 1 week and 3 months of treatment. Glutathione reductase (G-red) activity was found to be higher in GK rats. Glutathione peroxidase activity was lower in GK and rats treated with STZ for 1 month, which is in accordance with the proposal of functional recovery in these animals. We conclude that hyperglycemia has an adverse effect in sperm concentration and motility via changes in energy production and free radical management. Furthermore, both animal models, particularly GK rats and rats treated with STZ for 1 month, present some metabolic adaptations, increasing the efficiency of mitochondrial ATP production, in order to circumvent the deleterious effects promoted by the disease.

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Ion-Exchange Chromatography of Amino Acids in Ejaculates of Diabetics

Cited by 6 publications

References 7 publications

The Effect of Hydro-Alcoholic Allium sativum Extract on Sexual Hormones in Mature Male Rats Under Chemotherapy With Cyclophosphamide

The Effect of Hydro-Alcoholic Allium sativum Extract on Sexual Hormones in Mature Male Rats Under Chemotherapy With Cyclophosphamide

Insulin and Zinc Co-Administration Ameliorate Diabetes Mellitus-Induced Reproductive Dysfunction in Male Rats

Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and streptozotocin-treated rat models for diabetes

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