Ion-combination specific effects driving enzymatic activity of halophilic Alcohol Dehydrogenase 2 from Haloferax volcanii in aqueous ionic liquid solvent mixtures
Alexandra Schindl,
M. Lawrence Hagen,
Christof M. Jäger
et al.
Abstract:Biocatalysis in ionic liquids enables novel routes for bioprocessing. Enzymes derived from extremophiles promise greater stability and activity under ionic liquid (IL) influence. Here, we probe the enzyme Alcohol Dehydrogenase 2 from the halophilic archaeon Haloferax volcanii in thirteen different ion combinations for relative specific activity and analyse the results against MD simulations of the same IL systems. We probe the ionic liquid property space based on ion polarizability and molecular electrostatic … Show more
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