Wiley Encyclopedia of Chemical Biology 2008
DOI: 10.1002/9780470048672.wecb260
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Ion Channels in Medicine

Abstract: Our current understanding of ion channels has been made possible by techniques such as electrophysiology and molecular biology, but genetics‐based approaches inspired by associated diseases have pointed to regions of functional significance on the ion channels. The ion channelopathies are caused by mutations of corresponding genes or autoantibodies. Although the channels form a highly diverse group (cation, anion, voltage‐gated, ligand‐gated) and are expressed in excitable and nonexcitable tissues, underlying … Show more

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