Ion channels in canalicular rat liver plasma membranes

Sellinger, M.; Weinman, Steven A.; Boyer, James L.; Graf, Josef A.

doi:10.1016/0168-8278(89)90344-9

Cited by 1 publication

(2 citation statements)

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“…Na+-dependent taurocholate transport across the sinusoidal 0-plasma membrane [7], intracellular taurocholate transport and 0E canalicular secretion, probably by an ATP-dependent process I I m ((8]; for reviews, see [9,10]). Cell swelling could interfere with each of these processes.…”

Section: E 200mentioning

confidence: 99%

“…Symbols: 0, aniso-osmoticity (225, 265, 345, 385 mosmol/l); V, A, glutamine (1 and 3 mM); M, glutamine (2 mM) plus glycine (2 mM). excretion in liver (for reviews, see [9,10]). The finding that hypoosmotic cell swelling increases the V.max for taurocholate excretion into bile therefore suggests that cell swelling also increases canalicular secretion.…”

Section: 60 80 100mentioning

confidence: 99%

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Cell swelling increases bile flow and taurocholate excretion into bile in isolated perfused rat liver

Hallbrucker

Läng

Gerok

et al. 1992

Biochemical Journal

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The effects of aniso-osmotically and amino-acid-induced cell-volume changes on bile flow and biliary taurocholate excretion were studied in isolated perfused rat liver. With taurocholate (100 microM) in the influent perfusate, hypo-osmotic exposure (225 mosmol/l) increased taurocholate excretion into bile and bile flow by 42 and 27% respectively, whereas inhibition by 32 and 47% respectively was observed after hyperosmotic (385 mosmol/l) exposure. The effects of aniso-moticity on taurocholate excretion into bile was observed throughout aniso-osmotic exposure, even after completion of volume-regulatory ion fluxes and were fully reversible upon re-exposure to normo-osmotic media. Hypo-osmotic cell swelling (225 mosmol/l) increased the Vmax. of taurocholate translocation from the sinusoidal compartment into bile about 2-fold. Also, cell swelling induced by glutamine and glycine stimulated both bile flow and biliary taurocholate excretion. There was a close relationship between the aniso-osmotically and amino-acid-induced change of cell volume and taurocholate excretion into bile. The data suggest that liver cell volume plays an important role in regulating bile-acid-dependent bile flow and biliary taurocholate excretion.

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Section: E 200mentioning

confidence: 99%

Section: 60 80 100mentioning

confidence: 99%