Ion channels in autoimmune neurodegeneration

Ehling, Petra; Bittner, Stefan; Budde, Thomas; Wiendl, Heinz; Meuth, Sven G.

doi:10.1016/j.febslet.2011.03.065

Cited by 30 publications

(20 citation statements)

References 79 publications

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“…In neurons, outward K + leak currents hyperpolarize the membrane potential (V m ), which may, by limiting Ca 2+ influx via voltage-dependent calcium channels (VDCCs), reduce intracellular Ca 2+ levels ([Ca 2+ ] i ) (Catterall, 2011; Ehling et al, 2011; Lazarenko et al, 2010; Sirois et al, 2000). An increase in [Ca 2+ ] i promotes cAMP production in cells, possibly by directly stimulating Adenylyl Cyclase activity (Maus et al, 2017; Wong et al, 1999).…”

Section: Resultsmentioning

confidence: 99%

Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity

Chen

Zeng

Huang

et al. 2017

Cell

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Summary Adrenergic stimulation promotes lipid mobilization and oxidation in brown and beige adipocytes, where the harnessed energy is dissipated as heat in a process known as adaptive thermogenesis. The signaling cascades and energy-dissipating pathways that facilitate thermogenesis have been extensively described, yet little is known about the counter-balancing negative regulatory mechanisms. Here we identify a two-pore-domain potassium channel Kcnk3 as a built-in rheostat negatively regulating thermogenesis. Kcnk3 is transcriptionally wired into the thermogenic program by Prdm16, a master regulator of thermogenesis. Kcnk3 antagonizes norepinephrine-induced membrane depolarization by promoting potassium efflux in brown adipocytes. This limits calcium influx through voltage-dependent calcium channels and dampens adrenergic signaling, thereby attenuating lipolysis and thermogenic respiration. Adipose-specific Kcnk3 knockout mice display increased energy expenditure and are resistant to hypothermia and obesity. These findings uncover a critical K+-Ca2+-adrenergic signaling axis to dampen thermogenesis and maintain tissue homeostasis and reveal an electrophysiological regulatory mechanism of adipocyte function.

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Section: Resultsmentioning

confidence: 99%

Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity

Chen

Zeng

Huang

et al. 2017

Cell

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“…Similarly, potassium voltage‐gated channel family genes KCNQ1 and KCNA1 were noted in the RA and PD gene lists. Together with the finding of AQP1 another gated channel regulator as a hub PPI node among the differential genes, ion channels can be suggested as research targets in the context of RA and PD, as has been proposed for autoimmune diseases …”

Section: Discussionmentioning

confidence: 97%

Biological links in periodontitis and rheumatoid arthritis: Discovery via text‐mining PubMed abstracts

Acharya

Liu

et al. 2018

J of Periodontal Research

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Background and Objective Primary research concerning molecular pathways that link rheumatoid arthritis with periodontitis is limited. Biomedical literature data mining can offer insights into putative linkage mechanisms toward hypothesis development, based on information discovery. The aim of this study was to explore potential Periodontitis‐Rheumatoid Arthritis biological links by analysing “overlapping” genes reported in biomedical abstracts. Material and Methods PubMed abstracts for terms: (a) “Periodontitis” or “Periodontal Diseases” (PD), (b) “Rheumatoid arthritis” (RA), and (c) their combination with “AND” (RA+PD), were each text‐mined to extract genes using “Human Genome Nomenclature Committee” (HGNC) symbols. A gene‐set common to RA and PD abstracts was determined (RA∩PD). Gene ontology (GO) profiles of RA∩PD and RA+PD were compared using “GoProfiler.” Minimum order protein‐protein interaction (PPI) and gene‐miRNA networks of “differential genes” between RA∩PD and RA+PD were constructed with “networkAnalyst.” Results Among 1676 genes documented in RA (10 5241 abstracts), and 893 genes in PD (80 982 abstracts), 535 genes were common (RA∩PD), from which 35 genes were also documented in RA+PD (415 abstracts). 41 GO‐terms significantly different between RA∩PD and RA+PD GO profiles represented 38 biological processes including; nitric oxide metabolism, immunoglobulin production, hormonal regulation, catabolic process down‐regulation, and leukocyte proliferation. The 500 differential genes’ PPI and gene‐miRNA networks showed REL, TRAF2, AQP1 genes, and miRNAs 335‐5p, 17‐5p, 93‐5p with genes HMOX1 and SP1 as hub nodes. Conclusions Text‐mining biomedical abstracts revealed potentially shared but un‐investigated links between PD and RA, meriting further research.

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“…Ionic conductances are involved in both T cell activation, neural function and neurodegeneration and voltagegated Na + , K + and Ca 2+ ion channels are located on nerve cells and lymphocytes, respectively [8]. So far, beneficial and anti-inflammatory effects in context of a primarily autoimmune disease of the central nervous system have been described for carbamazepine and phenytoin, two established ion channel inhibitors [9].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects of levetiracetam in experimental autoimmune encephalomyelitis

Thöne

Ellrichmann

Faustmann

et al. 2012

International Immunopharmacology

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Ion channels in autoimmune neurodegeneration

Cited by 30 publications

References 79 publications

Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity

Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity

Biological links in periodontitis and rheumatoid arthritis: Discovery via text‐mining PubMed abstracts

Anti-inflammatory effects of levetiracetam in experimental autoimmune encephalomyelitis

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