Ion channels and diseases

Hatta, Shinichi; Sakamoto, Jun; Horio, Yoshiyuki

doi:10.1007/s007950200015

Cited by 35 publications

(17 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[95], although the incidence of Kv channel polymorphism in a diabetic cohort has not been investigated. Mutations in Kv and related channels are known to play important roles in disorders such as familial long QT syndrome, episodic ataxia type 1, benign familial neonatal convulsion, familial and thyrotoxic hypokalemic periodic paralysis, and autosomal dominant deafness [96]. Polymorphism of Kv channels or their numerous regulatory proteins could lead to loss or gain of function.…”

Section: Electrophysiological Evidence For Different Repolarising Curmentioning

confidence: 99%

Voltage-dependent K + channels in pancreatic beta cells: Role, regulation and potential as therapeutic targets

2003

View full text Add to dashboard Cite

Insulin secretion from pancreatic islet beta cells is acutely regulated by a complex interplay of metabolic and electrogenic events. The electrogenic mechanism regulating insulin secretion from beta cells is commonly referred to as the ATP-sensitive K + (K ATP ) channel dependent pathway. Briefly, an increase in ATP and, perhaps more importantly, a decrease in ADP stimulated by glucose metabolism depolarises the beta cell by closing K ATP channels. Membrane depolarisation results in the opening of voltage-dependent Ca 2+ channels, and influx of Ca 2+ is the main trigger for insulin secretion. Repolarisation of pancreatic beta cell action potential is mediated by the activation of voltage-dependent K + (Kv) channels. Various Kv channel homologues have been detected in insulin secreting cells, and recent studies have shown a role for specific Kv channels as modulators of insulin secretion. Here we review the evidence supporting a role for Kv channels in the regulation of insulin secretion and discuss the potential and the limitations for beta-cell Kv channels as therapeutic targets. Furthermore, we review recent investigations of mechanisms regulating Kv channels in beta cells, which suggest that Kv channels are active participants in the regulation of beta-cell electrical activity and insulin secretion. [Diabetologia (2003[Diabetologia ( ) 46:1046[Diabetologia ( -1062

show abstract

Section: Electrophysiological Evidence For Different Repolarising Curmentioning

confidence: 99%

Voltage-dependent K + channels in pancreatic beta cells: Role, regulation and potential as therapeutic targets

2003

View full text Add to dashboard Cite

show abstract

“…Ion channels play important roles in both excitable and nonexcitable cells (Hatta et al, 2002). Voltage-dependent sodium, calcium, and potassium channels have been involved in a wide variety of cell functions (Snyders, 1999).…”

mentioning

confidence: 99%

“…Voltagedependent ion channels consist of a pore-forming component, the ␣-subunit, and additional ancillary or regulatory ␤-subunits. The voltage-dependent potassium channel ␣-subunits contain two to six transmembrane regions and, in most cases, four subunits are required for the assembly and formation of functional potassium channel (Hatta et al, 2002). In native cells, potassium channels incorporate additional subunits, ancillary or regulatory ␤-subunits, that modify attributes such as surface half-life, ion selectivity, gating kinetics, chemical and secondary messenger regulation, and pharmacological properties (Abbott and Goldstein, 2001).…”

mentioning

confidence: 99%

Protein distribution of Kcnq1, Kcnh2, and Kcne3 potassium channel subunits during mouse embryonic development

2006

View full text Add to dashboard Cite

Voltage-dependent potassium channels consist of a pore-forming ␣-subunit, which is modulated by additional ␤-ancillary or regulatory subunits. Kcnq1 and Kcnh2 ␣-channel subunits play pivotal roles in the developing and adult heart. However, Kcnq1 and Kcnh2 have a much wider expression profile than strictly confined to the myocardium, similar to their putative regulatory Kcne1-5 ␤-subunits. At present, the distribution of distinct potassium channel subunits has been partially mapped in adult tissues, whereas almost no information is available during embryonic development. In this study, we report a detailed analysis of Kcnq1, Kcnh2, and Kcne3 protein expression during mouse embryogenesis. Our results demonstrate that Kcnq1 and Kcnh2 are widely distributed. Coexpression of both ␣-subunits is observed in a wide variety of organs, such as heart and the skeletal muscle, whereas others display unique Kcnq1 or Knch2 expression. Interestingly, Kcne3 expression is also widely observed in distinct tissue layers during embryogenesis, supporting the notion that an exquisite balance of ␣-and ␤-subunit expression is required for modulating potassium conductance in distinct organs and tissue layers.

show abstract

“…Na and K are elements which are closely connected with each other in the bodies of living organisms. Their proper ratio is essential for sustaining the acid-base balance and water-electrolyte homeostasis in the organism (Hatta et al, 2002). The content of K in the hair of cows stayed within the range of 3.0 to 3.7 g*kg -1 , depending on the season and the breeding center (Tables 1.-5.).…”

Section: Discussionmentioning

confidence: 99%

Impact of the breeding region and the season on the content of the selected mineral elements in the hair of cows

Cygan-Szczegielniak¹,

Stanek²,

Giernatowska³

et al. 2015

JCEA

View full text Add to dashboard Cite

The aim of the research was to analyze the effect of the season and the breeding region on the content of selected minerals (Ca, Mg, Na and K) in the hair of dairy cows. The research material was made up of 114 polish Holstein-Friesians breed cows from three breeding centres in Poland: Kombinat Rolny Sp. z o. o. -Kietrz (the opolskie province), Hodowla Zarodowa Zwierząt Sp. z o.o. -Knyszyn (the podlaskie province) and Ośrodek Hodowli Zarodowej Sp. z o.o. -Osięciny (the kujawskopomorskie province). The cows were kept in freestanding cowsheds with den boxes. The animal nutrition involved the use of the TMR system, considering the division into nutrition groups. The hair was sampled in summer and in the period of winter and spring from the side of the body, right behind the coastal arch. Determination of Ca, Mg, Na and K was performed by means of atomic absorption spectrophotometry (AAS). The study revealed seasonal variations in the content of mineral elements in the hair of dry cows and a region-dependent differentiation. The highest content of the quantity elements in question was found in the hair of the cows from Osięciny. The mean concentration of Ca, Mg, Na and K in the hair of cows from Osięciny was statistically significantly higher than in the hair collected in winter from the animals from Knyszyn and Kietrz. The lowest values of the determined elements were noted in the hair of cows bred in Knyszyn. The investigation of the correlation between the amounts of the elements, based on an analysis of all samples of hair, revealed a positive correlation between Na and K cations, as well as between Mg and Ca cations.

show abstract

Ion channels and diseases

Cited by 35 publications

References 70 publications

Voltage-dependent K + channels in pancreatic beta cells: Role, regulation and potential as therapeutic targets

Voltage-dependent K + channels in pancreatic beta cells: Role, regulation and potential as therapeutic targets

Protein distribution of Kcnq1, Kcnh2, and Kcne3 potassium channel subunits during mouse embryonic development

Impact of the breeding region and the season on the content of the selected mineral elements in the hair of cows

Contact Info

Product

Resources

About