Ion Activation Methods for Tandem Mass Spectrometry

Håkansson, Kristina; Klassen, John S.

doi:10.1002/9780470588901.ch16

Cited by 6 publications

(2 citation statements)

References 306 publications

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“…Therefore, multiple fragmentation events may take place. One of the major advantages of IRMPD in FT-ICR MS is that no collision gas needs to be introduced to the ICR cell [116]. In addition, IRMPD provides on-axis fragmentation, thus there is no loss of resolution.…”

Section: Ms/ms Techniques In High Resolution Mass Spectrometrymentioning

confidence: 99%

Structural Characterization of Carbohydrates by Fourier Transform Tandem Mass Spectrometry

Zhou

Håkansson²

2011

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Fourier transform tandem mass spectrometry (MS/MS) provides high mass accuracy, high sensitivity, and analytical versatility and has therefore emerged as an indispensable tool for structural elucidation of biomolecules. Glycosylation is one of the most common posttranslational modifications, occurring in ~50% of proteins. However, due to the structural diversity of carbohydrates, arising from non-template driven biosynthesis, achievement of detailed structural insight is highly challenging. This review briefly discusses carbohydrate sample preparation and ionization methods, and highlights recent developments in alternative high-resolution MS/MS strategies, including infrared multiphoton dissociation (IRMPD), electron capture dissociation (ECD), and electron detachment dissociation (EDD), for carbohydrates with a focus on glycans and proteoglycans from mammalian glycoproteins.

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Section: Ms/ms Techniques In High Resolution Mass Spectrometrymentioning

confidence: 99%

Structural Characterization of Carbohydrates by Fourier Transform Tandem Mass Spectrometry

Zhou

Håkansson²

2011

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“…As previously indicated, the knowledge of the thermal deactivation process of common UV-MALDI matrices together with other mechanistical aspects discussed in the literature can play an important role in understanding why some matrices lead to more abundant postsource decay as well as prompt decay of the analyte. [19][20][21] Even though the desorption-ionization process in UV-MALDI-MS takes place in a vacuum atmosphere chamber, atmospheric pressure (AP) MALDI sources have been described recently and are very attractive because of the possibility of reducing equipment.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic and luminescence characterization of nitrogen heterocyclic aromatic UV-MALDI matrices in solution

Petroselli

Erra‐Balsells

Gara

et al. 2012

Photochem Photobiol Sci

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A group of nitrogen heterocyclic aromatic compounds used, among others, as UV-MALDI matrices was studied. By using spectroscopic, luminescence and photoacoustic techniques, as well as time resolved phosphorescence for singlet oxygen production determination, the behaviour of 9-aminoacridine (9AA), 3-aminoquinoline (3AQ), 2-(2-aminoethylamino)-5-nitropyridine (AAN) and 3,4-dihydro-7-methoxy-1-methyl-9H-pyrido[3,4-b] indole (harmaline, HLA) in acetonitrile solutions is described. The results show that for these compounds radiationless processes that release prompt heat to the media are a quite important deactivation mechanism.

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Tandem Mass Spectrometry Analysis of Polymer Structures and Architectures

Scionti¹,

Wesdemiotis²

2011

Mass Spectrometry in Polymer Chemistry

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Ion Activation Methods for Tandem Mass Spectrometry

Cited by 6 publications

References 306 publications

Structural Characterization of Carbohydrates by Fourier Transform Tandem Mass Spectrometry

Structural Characterization of Carbohydrates by Fourier Transform Tandem Mass Spectrometry

Photoacoustic and luminescence characterization of nitrogen heterocyclic aromatic UV-MALDI matrices in solution

Tandem Mass Spectrometry Analysis of Polymer Structures and Architectures

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