IOM Committee Members Respond to Endocrine Society Vitamin D Guideline

Rosen, Clifford J.; Abrams, Steven A.; Aloia, John F.; Brannon, Patsy M.; Clinton, Steven K.; Durazo‐Arvizu, Ramón; Gallagher, J. Christopher; Gallo, Richard L.; Jones, Glenville; Kovacs, Christopher S.; Manson, Jo Ann E.; Mayne, Susan T.; Ross, A. Catharine; Shapses, Sue A.; Taylor, Christine L.

doi:10.1210/jc.2011-2218

Cited by 487 publications

(311 citation statements)

References 20 publications

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“…Apparently, using our supplementation policy, baseline serum 25(OH)D is the strongest predictor for the magnitude of 25(OH)D change, not the dose itself, even when using high supplementation doses. Using a standard supplementation dose of 800 IU/day, as advocated in many guidelines on osteoporosis and fractre prevention (23,24), the percentage of patients reaching a serum 25(OH)D level R50 nmol/l were similar when using higher doses, at any baseline serum 25(OH)D. This result confirms that baseline serum 25(OH)D is the most important predictor of response to vitamin D3 supplementation. Therefore, if the aim is to achieve a serum 25(OH)D R50 nmol/l, as in our study, higher vitamin D supplementation doses than 800 IU/day are not needed (6,7,24).…”

Section: Discussionsupporting

confidence: 61%

Suboptimal effect of different vitamin D3 supplementations and doses adapted to baseline serum 25(OH)D on achieved 25(OH)D levels in patients with a recent fracture: a prospective observational study

Shab-Bidar

Bours

Geusens

et al. 2013

European Journal of Endocrinology

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Objective: Guidelines on the need for dose adaptation of vitamin D3 supplementation according to baseline serum 25(OH)D are inconclusive. The effects of increasing doses of vitamin D3 at lower baseline serum 25(OH)D values on the serum 25(OH)D after 4.2 and 11 months were determined in an observational study. Design: A prospective observational study. Methods: Out of 1481 consecutive women and men with a recent clinical fracture, 707 had a baseline 25(OH)D level !50 nmol/l and were supplemented with increasing doses of vitamin D3 (400, 800, 1700, and R3500 IU/day) according to the lower baseline 25(OH)D. Final analysis was restricted to the 221 participants who had full follow-up data available for 11 months. Results: Serum 25(OH)D R50 nmol/l was achieved in 57-76% of patients after 4.2 months and in 73-79% after 11 months. These percentages were similar for all doses (PZ0.06 and PZ0.91 respectively). The mean achieved 25(OH)D was similar for all dose groups (56.1-64.0 nmol/l after 4.2 months and 60.2-76.3 nmol/l after 11 months). With multivariate analysis, the increase in 25(OH)D (17G32.0 after 4.2 months and 24.3G34.0 nmol/l after 11 months) was dependent on the baseline 25(OH)D (P!0.001), not on supplementation dose, season, age, BMI, or gender. Conclusions: The increase in serum 25(OH)D was significantly larger with higher vitamin D3 supplementation doses. However, this dose-effect response was mainly explained by the baseline 25(OH)D, not the supplementation dose, with a greater magnitude of response at lower baseline 25(OH)D concentrations. In 21-27% of patients, serum 25(OH)D3 levels did not reach 50 nmol/l after 11 months, at any dose. Further studies are needed to identify possible causes of suboptimal response such as non-compliance, undiagnosed malabsorption syndromes, or variability in cholecalciferol content of the vitamin D supplements.

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Section: Discussionsupporting

confidence: 61%

Suboptimal effect of different vitamin D3 supplementations and doses adapted to baseline serum 25(OH)D on achieved 25(OH)D levels in patients with a recent fracture: a prospective observational study

Shab-Bidar

Bours

Geusens

et al. 2013

European Journal of Endocrinology

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“…24,26 La falta de unidad en los valores de referencia utilizados para la clasificación de las deficiencias e insuficiencias en los diferentes estudios también causa una gran variabilidad en los reportes e impide un adecuado análisis de la situación a nivel regional. 27,28 En general, habrá que considerar que la insuficiencia de vitamina D corresponde a valores séricos inferiores a 30 ng/ml y que la deficiencia a valores inferiores a 20 ng/ml son los criterios más aceptados a nivel mundial, 13 aunque no necesariamente son considerados los mejores, ya que algunos autores asocian niveles séricos más altos de esta vitamina con efectos protectores contra enfermedades como el cáncer. 2,13 Realizar estudios como el aquí presentado sobre los niveles de vitamina D de la población saludable en un determinado entorno resulta de gran importancia como referencia para futuros estudios de grupos poblacionales comparables pero en otras condiciones de salud.…”

Section: Cuadro Iunclassified

Estado de la 25-hidroxivitamina D sérica en niños sanos menores de 10 años del área metropolitana de Barranquilla

Acosta-Bendek¹,

Sánchez-Majana

Fonseca-Galé³

et al. 2017

Salud Publica Mex

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Objetivo. Evaluar los niveles séricos de 25-hidroxivitamina D (25-OH-D) en niños sanos menores de 10 años del área metropolitana de Barranquilla (AMB). Material y métodos. Estudio descriptivo de corte transversal, que evaluó los niveles séricos de 25-OH-D en 360 niños del AMB en los años 2014-2015. Resultados. El valor promedio de 25-OH-D en la población estudiada fue 32.23±8.56 ng/mL; 46.38% de los niños tenía niveles de vitamina D considerados insuficientes (<30 ng/mL) y 3.05% mostro deficiencia (<20 ng/mL). Soledad y Puerto Colombia fueron los municipios con mayor población en esta condición. Conclusiones. Es necesario generar programas de suplementación nutricional y fomentar estilos de vida que permitan, de forma segura, mejorar los niveles de vitamina D en la población.

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“…Some experts consider serum 25(OH)D concentrations higher than 75 nmol/l as adequate not just for bone health, but for the non-skeletal effects as well (3,4). Others suggest that serum 25(OH)D concentrations of 50 nmol/l are sufficient (5).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D status and metabolic syndrome in the elderly: the Rotterdam Study

Vitezova

Zillikens

Herpt

et al. 2015

European Journal of Endocrinology

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Objective: The effects of vitamin D in the elderly are inconsistent. The aim of this study was to evaluate the association between vitamin D status and the metabolic syndrome (MetS) in the elderly, as well as between vitamin D status and the components of MetS (i.e. serum glucose, triglycerides (TG), HDL cholesterol (HDL-C), waist circumference (WC), and blood pressure (BP)). Methods: The study was embedded in the Rotterdam Study, a population-based cohort of middle-aged and elderly adults. We analyzed data from 3240 people (median age 71.2 years) who did not have type 2 diabetes mellitus at baseline.

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IOM Committee Members Respond to Endocrine Society Vitamin D Guideline

Cited by 487 publications

References 20 publications

Suboptimal effect of different vitamin D3 supplementations and doses adapted to baseline serum 25(OH)D on achieved 25(OH)D levels in patients with a recent fracture: a prospective observational study

Suboptimal effect of different vitamin D3 supplementations and doses adapted to baseline serum 25(OH)D on achieved 25(OH)D levels in patients with a recent fracture: a prospective observational study

Estado de la 25-hidroxivitamina D sérica en niños sanos menores de 10 años del área metropolitana de Barranquilla

Vitamin D status and metabolic syndrome in the elderly: the Rotterdam Study

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