Iohexol-Induced Neutrophil Myeloperoxidase Release and Activation Upon Contact With Vascular Stent-Graft Material: A Mechanism Contributing to the Postimplantation Syndrome?

Abstract

Iohexol induces neutrophil degranulation, which is greatly enhanced when combined with vascular stent-graft material. Thus, iohexol-induced neutrophil activation may contribute to an inflammatory response following stent-graft implantation. We speculate that neutrophil activation during other procedures combining catheters and iohexol (e.g., angiography) may induce inflammation, which might have detrimental effects.

Volume of new-onset thrombus is associated with the development of postimplantation syndrome after endovascular aneurysm repair

“…Injury of the endothelium during implantation, bacterial translocation due to transient sigmoid ischemia, contrast medium-induced neutrophil degranulation, endovascular instrumentation of the mural thrombus, and thrombosis of the aneurysm sac after aneurysm exclusion have been proposed as factors triggering the pathophysiologic process leading to PIS. [7][8][9][10][11][12] In a previous study with this same group of patients, we had demonstrated that the type of endograft plays a pivotal role in the inflammatory response after EVAR. 7 The aim of the present study was to evaluate the impact of contrast medium volume, inferior mesenteric artery (IMA) patency, and pre-existing as well as new-onset thrombus on the inflammatory response after elective EVAR.…”

The impact of endograft type on inflammatory response after endovascular treatment of abdominal aortic aneurysm

“…14 Our results are consistent with this study. Videm et al 15 suggested that the contrast medium iohexol induces neutrophil degranulation, which is greatly enhanced when combined with vascular stent graft material contributing to the postimplantation syndrome. This study was based on analysis of whole blood or isolated neutrophils in five patients undergoing diagnostic angiography, and the dose for maximal response ranged from 5 to 50 mg I/mL.…”

Changes in Neutrophil Surface‐Receptor Expression After Stimulation with FMLP, Endotoxin, Interleukin‐8 and Activated Complement Compared to Degranulation

“…Our findings, however, should not lead to the conclusion that flow cytometric assessment of surface-molecule expression is the only useful indicator of neutrophil activation in all experimental settings. Measurement of degranulation is very simple and useful with strong responses or large differences, as shown for example in studies of activation induced by radiographic contrast media [26]. The method also gives a good 'summary measure' for activation over time.…”