Iodonium salt incorporation in dental adhesives and its relation with degree of conversion, ultimate tensile strength, cell viability, and oxidative stress

Ferrúa, Camila Perelló; Leal, Fernanda; Gazal, Marta; Ghisleni, Gabriele; Carvalho, Rodrigo Varella de; Demarco, Flávio Fernando; Ogliari, Fabrício Aulo; Nedel, Fernanda

doi:10.1007/s00784-018-2527-6

Cited by 6 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For this purpose, CS- g -PNIPAAm/PVA 75/25 formulation was tested on two healthy distinct cell lines: In human kidney proximal tubular epithelial cell line (HK-2) and mouse embryonic fibroblast cell line (NIH-3T3). Epithelial and fibroblast cell lines are frequently used in such preliminary cytotoxic studies [30,31,32,33,34,35,36].…”

Section: Resultsmentioning

confidence: 99%

Chitosan-Graft-Poly(N-Isopropylacrylamide)/PVA Cryogels as Carriers for Mucosal Delivery of Voriconazole

et al. 2019

View full text Add to dashboard Cite

The objective of this study was to prepare and characterize physically crosslinked gel formulations of chitosan (CS)-graft-poly(N-isopropyl acrylamide) (PNIPAAm) and polyvinyl alcohol (PVA) for smart delivery of an antifungal drug, Voriconazole, for mucosal applications. For this purpose, cryogels of CS-g-PNIPAAm/PVA and CS/PVA were tested by means of texture profile analysis and rheology to determine optimal matrix properties for topical application. The ratio of 75/25 v/v % CS-g-PNIPAAm/PVA was selected to be used for formulation since it gave low compressibility and hardness (1.2 and 0.6 N) as well as high adhesion properties and non-Newtonian flow behavior. The cryogels and formulations were further characterized by means of FTIR spectroscopy, swelling behavior, texture analysis, scanning electron microscopy (SEM), thermal (differential scanning calorimetry (DSC) and TGA), and rheological behavior. The drug loading capacity and in vitro release profile of the drug, storage stability, and cytotoxicity tests were also performed for the gel formulation. The FTIR, DSC, and TGA results verified the successful formation of cryogels. Swelling studies revealed a pH-dependent swelling ability with a maximum swelling degree of 1200% in acid and 990% in phosphate buffer (pH = 7.4). Thermal studies showed that CS-g-PNIPAAm/PVA 75/25 had higher thermal stability proving the structural complexity of the polymer. The loading capacity of Voriconazole was found to be 70% (w/w). The in vitro release profiles of Voriconazole showed Fickian release behavior for CS-g-PNIPAAm/PVA 75/25 gel with an approximate delivery of 38% within 8 h, slower than matrices containing unmodified chitosan. The storage stability test exhibited that the gel formulation was still stable even after aging for two months. Moreover, the cell culture assays revealed a non-toxic character of the polymeric matrix. Overall results showed that the CS-g-PNIPAAm/PVA 75/25 hydrogel has the potential to be used as a smart polymeric vehicle for topical applications.

show abstract

Section: Resultsmentioning

confidence: 99%

Chitosan-Graft-Poly(N-Isopropylacrylamide)/PVA Cryogels as Carriers for Mucosal Delivery of Voriconazole

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The sample size (n = 3 per group) was estimated based on the data of a previous study that evaluated the antibacterial activity of resin-based endodontic sealers to Enterococcus faecalis. 19 Secondary response variables related to the characterization of the periodontal dressing materials were the degree of C=C conversion (n = 3), 19 cohesive strength (n = 5), 20 water sorption and solubility (n = 10), 21 and cell viability (n = 4). 21 The dressing materials were formulated according to Table 1.…”

Section: Methodology Experimental Designmentioning

confidence: 99%

Effect of alpha-humulene incorporation on the properties of experimental light-cured periodontal dressings

Rossato

Alves²,

Cuevas‐Suárez

et al. 2022

Braz. oral res.

View full text Add to dashboard Cite

The objective of this study was to formulate an experimental light-cured periodontal dressing containing alpha-humulene and to compare its physical, antimicrobial, and cytotoxicity properties with commercial gold standards (Barricaid ® and Periobond ® ). Two periodontal dressing formulations were developed (a and b). The formulations were divided into 5 groups according to the alpha-humulene concentration as follows: Ea -control group, Ea 1 -1%, Ea 5 -5%, Ea 10 -10%, and Ea 20 -20%; Eb -control group, Eb 1 -1%, Eb 5 -5%, Eb 10 -10%, and Eb 20 -20%. Materials characterization was performed using the degree of conversion, cohesive strength, sorption, and solubility assays. Antimicrobial assay was performed using the modified direct contact test against E. faecalis and S. aureus. Cytotoxicity was assessed by the cell viability experiment using L929 fibroblasts. In general, the cohesive strength values of materials decreased as the alpha-humulene concentration increased. All the experimental dressings showed antimicrobial activity against both bacteria tested. Cell viability results for the Ea, Ea 1 , Eb, and Eb 1 groups showed moderate cytotoxic effect. The formulations containing alpha-humulene showed similar behavior to the commercial references. Thus, formulations containing alpha-humulene have potential to be used as periodontal dressing.

show abstract

Effect of the photoinitiator system on the polymerization of secondary methacrylamides of systematically varied structure for dental adhesive applications

et al. 2020

View full text Add to dashboard Cite

Iodonium salt incorporation in dental adhesives and its relation with degree of conversion, ultimate tensile strength, cell viability, and oxidative stress

Abstract: Our study emphasizes the relevance of incorporating the third element-iodonium salt-in a binary adhesive systems composed exclusively of CQ and EDAB.

Cited by 6 publications

References 37 publications

Chitosan-Graft-Poly(N-Isopropylacrylamide)/PVA Cryogels as Carriers for Mucosal Delivery of Voriconazole

Chitosan-Graft-Poly(N-Isopropylacrylamide)/PVA Cryogels as Carriers for Mucosal Delivery of Voriconazole

Effect of alpha-humulene incorporation on the properties of experimental light-cured periodontal dressings

Effect of the photoinitiator system on the polymerization of secondary methacrylamides of systematically varied structure for dental adhesive applications

Contact Info

Product

Resources

About