Iodo-bridged complexes of platinum(II) and synthesis of cis mixed-amine platinum(II) compounds

Platinum(II)‐Acyclovir Complexes: Synthesis, Antiviral andAntitumour Activity

“…The sequence selectivity of DNA modification by platinum complexes was evaluated by the primer extension footprinting assay (13,14). PBR 322 double stranded DNA (1.5x10 -8 mol nucleotides) was reacted with platinum complexes (drug/nucleotide molar ratio 0.02) in a total volume of 10 …”

Synthesis, characterization and cytotoxicity of ammine/ethylamine platinum(II) complexes with carboxylates

“…According to the literature [15], the binuclear platinum complexes [PtLI 2 ] 2 were synthesized from the reaction of cis-[Pt(L) 2 I 2 ] (L ¼ amine) with perchloric acid. In these conditions, one amine is protonated.…”

Combinatorial discovery of new asymmetric platinum anticancer complexes is made possible with solid-phase synthetic methods

“…Most cisplatin analogues described in the literature contain either two identical amine ligands, a chelating didentate ligand or an ammine and an amine ligand. Asymmetrical complexes with two different amine substituents coordinating in cis position present an attractive, but as yet less studied class of platinum complexes with cytotoxic potential [5][6][7][8][9][10][11]. An efficient synthetic method that could be applied for a combinatorial evaluation of this class of compounds would enable in-depth analysis leading to a better understanding of these complexes.…”

“…In solution, it is difficult to form such a mono-amine complex: in the reaction of [PtX 4 ] 2À with one equivalent of N-donating ligand there is little or no control over mono-versus disubstitution, in fact, there is even a preference to form the cis diamine species. The three-step procedure as described by Rochon et al [5] involving a bridged dinuclear intermediate is a useful method to access asymmetrical cis-diamineplatinum complexes in solution. However, this procedure is rather delicate and unsuitable for the rapid preparation of an array of asymmetric cisplatin analogues.…”

“…After characterisation, the crude complexes were subjected to a cytotoxicity screen, which revealed several complexes with activities comparable to cisplatin. Two of the more active compounds were selected and resynthesised on larger scale in solution using earlier described methods [5,10]. These two compounds were analysed in detail and their IC 50 value was determined in two different cell lines, sensitive and resistant to cisplatin.…”