Iodine Supplementation Decreases Hypercholesterolemia in Iodine-Deficient, Overweight Women: A Randomized Controlled Trial ,

Herter-Aeberli, Isabelle; Cherkaoui, Mohamed; Ansari, N. El; Rohner, R; Stinca, Sara; Chabaâ, L.; Eckardstein, Arnold von; Aboussad, A.; Zimmermann, Michael

doi:10.3945/jn.115.213439

Cited by 35 publications

(22 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Iodine supplement treatment for euthyroid goiter on children resulted significant decrease in total cholesterol and LDL cholesterol to their normal level [ 43 ]. A recent randomized controlled intervention study also reported that 6-month intervention with iodine supplementation significantly decreased risks for hypercholesterolemia in overweight and obese Moroccan women [ 44 ]. Additionally, a rural African population-based study reported that pregnant women and their offspring in an iodine deficient area are more likely to have a risk of coronary complications and hyperlipidemia compared to non-iodine deficient region [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Low Urinary Iodine Concentrations Associated with Dyslipidemia in US Adults

2016

View full text Add to dashboard Cite

Iodine is an essential component of the thyroid hormone which plays crucial roles in healthy thyroid function and lipid metabolism. However, the association between iodine status and dyslipidemia has not been well established at a population level. We aimed to test the hypothesis that the odds of dyslipidemia including elevated total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol and apolipoprotein B, and lowered high-density lipoprotein (HDL) cholesterol and HDL/LDL ratio are associated with urinary iodine concentration (UIC) in a population perspective. Data of 2495 US adults (≥20 years) in the National Health and Nutrition Examination Survey 2007–2012 were used in this study. Two subgroups (i.e., UIC below vs. above the 10th percentile) were compared of dyslipidemia as defined based on NCEP ATP III guidelines. The differences between the groups were tested statistically by chi-square test, simple linear regressions, and multiple logistic regressions. Serum lipid concentrations differed significantly between two iodine status groups when sociodemographic and lifestyle covariates were controlled (all, p < 0.05). Those with the lowest decile of UIC were more likely to be at risk for elevated total cholesterol (>200 mg/dL) (adjusted odds ratio (AOR) = 1.51, 95% confidence interval (CI): 1.03–2.23) and elevated LDL cholesterol (>130 mg/dL) (AOR = 1.58, 95% CI: 1.11–2.23) and lowered HDL/LDL ratio (<0.4) (AOR = 1.66, 95% CI: 1.18–2.33), compared to those with UIC above the 10th percentile. In US adults, low UIC was associated with increased odds for dyslipidemia. Findings of the present cross-sectional study with spot urine samples highlight the significant association between UIC and serum lipids at population level, but do not substantiate a causal relationship. Further investigations are warranted to elucidate the causal relationship among iodine intakes, iodine status, and serum lipid profiles.

show abstract

Section: Discussionmentioning

confidence: 99%

Low Urinary Iodine Concentrations Associated with Dyslipidemia in US Adults

2016

View full text Add to dashboard Cite

show abstract

“…Moderate iodine diets improve the lipid profile in mice, increasing low density lipoprotein receptors and scavenger receptor class B type 1 (SR-B1) in liver [46]. Moreover, iodine supplementation decreased hypercholesterolemia in overweight women [47]. More recently, our group showed that a moderate I 2 supplement prevented the pancreatic damage secondary to hypothyroidism by methimazole, normalizing thyroid hormone synthesis in the thyroid and preventing the oxidative status in pancreatic tissue [48].…”

Section: Antioxidant Effectsmentioning

confidence: 97%

Molecular Iodine Has Extrathyroidal Effects as an Antioxidant, Differentiator, and Immunomodulator

Aceves¹,

Mendieta²,

Anguiano³

et al. 2021

IJMS

View full text Add to dashboard Cite

Most investigations of iodine metabolism in humans and animals have focused on its role in thyroid function. However, considerable evidence indicates that iodine could also be implicated in the physiopathology of other organs. We review the literature that shows that molecular iodine (I2) exerts multiple and complex actions on the organs that capture it, not including its effects as part of thyroid hormones. This chemical form of iodine is internalized by a facilitated diffusion system that is evolutionary conserved, and its effects appear to be mediated by a variety of mechanisms and pathways. As an oxidized component, it directly neutralizes free radicals, induces the expression of type II antioxidant enzymes, or inactivates proinflammatory pathways. In neoplastic cells, I2 generates iodolipids with nuclear actions that include the activation of apoptotic pathways and the inhibition of markers related to stem cell maintenance, chemoresistance, and survival. Recently, I2 has been postulated as an immune modulator that depending on the cellular context, can function as an inhibitor or activator of immune responses. We propose that the intake of molecular iodine is increased in adults to at least 1 mg/day in specific pathologies to obtain the potential extrathyroid benefits described in this review.

show abstract

“…These findings suggest that moderate to severe iodine deficiency in overweight women elevates serum TSH and produces a more atherogenic lipid profile and iodine prophylaxis can reduce disease risk in overweight adult [39].…”

Section: Strong Evidence On Iodine Intakementioning

confidence: 81%

Iodine, ingesting or not?

Peres¹

2017

J Nutr Disorders Ther

View full text Add to dashboard Cite

Currently, the population use medicines that contain fluorine/chlorine and ingest bromide that is found in breads, thus they occupy the place iodine injuring the thyroid. Iodine deficiency is a major public health problem thus as medical iodophobia. This mini-review addresses the effect of iodine supplementation in the prevention and treatment of chronic diseases. In this baseline, there are six systematic reviews published in the last 6 years beyond WHO/ UNICEF encourage the safe use iodine in the dosages of 200 µg/day during in pregnancy and 250 µg/day in lactating women. However, one study Australian showed that of 396 healthcare providers only 71% were aware of the National Health and Medical Research Council's recommendation for iodine supplementation, (38%) were aware of the recommended dose or and (44%) duration. Beyond of knowing therapeutic property iodine, a clinical trial showed that iodine supplementation in overweight women reduces the prevalence of hypercholesterolemia. Although there is strong evidence showed that iodine prevents and fight various diseases some doctors and gynecologists still not prescribe iodine in pregnancy and lactation by fear, ignorance or lack of knowledge. Thereby, one change of paradigm in the current medical model in relation in to iodine intake needs to be urgently done.

show abstract

Iodine Supplementation Decreases Hypercholesterolemia in Iodine-Deficient, Overweight Women: A Randomized Controlled Trial ,

Cited by 35 publications

References 33 publications

Low Urinary Iodine Concentrations Associated with Dyslipidemia in US Adults

Low Urinary Iodine Concentrations Associated with Dyslipidemia in US Adults

Molecular Iodine Has Extrathyroidal Effects as an Antioxidant, Differentiator, and Immunomodulator

Iodine, ingesting or not?

Contact Info

Product

Resources

About