Iodine status of euthyroid adults: A cross‐sectional, multicenter study

Wang, Danchen; Yu, Songlin; Yin, Yanzhen; Xie, Shaowei; Cheng, Qian; Li, Honglei; Cheng, Xinqi; Qiu, Ling

doi:10.1002/jcla.22837

Cited by 15 publications

(11 citation statements)

References 15 publications

(30 reference statements)

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“…Smoking decreases the iodine level of visceral leishmaniasis patients by 12.34 mcg/l. This nding agrees with previous scholar's work [66]. This is due to the effect of smoking in disturbing the iodine metabolism [67,68].…”

Section: Discussionsupporting

confidence: 93%

Micronutrient levels and their effect on the prognosis of visceral leishmaniasis treatment; a prospective cohort study.

Feleke

2020

Preprint

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Background: Micronutrients are minerals and vitamins and they are essential for normal physiological activities. The objectives of the study were to describe the progress and determinants of micronutrient levels and to assess the effects of micronutrients in the treatment outcome of kalazar. Methods: A prospective cohort study design was used. The data were collected using patient interviews, measuring anthropometric indicators, and collecting laboratory samples. The blood samples were collected at five different periods during the leishmaniasis treatments: before starting anti-leishmaniasis treatments, in the first week, in the second week, in the third week, and in the 4th week of anti-leishmaniasis treatments. Descriptive statistics were used to describe the profile of patients and to compare the treatment success rate. The generalized estimating equation was used to identify the determinants of serum micronutrients.Results: The mean age of the patients were 32.88 years [SD (standard deviation) ±15.95]. Male constitute 62.3 % of the patients and problematic alcohol use was present in 11.5 % of the patients. The serum zinc level of visceral leishmaniasis patients was affected by alcohol (B -2.7 [95 % CI: -4.01 - -1.5]), DDS (B 9.75 [95 % CI: 7.71 – 11.79]), family size (B -1.63 [95 % CI: -2.68 - -0.58]), HIV (B -2.95 [95 % CI: -4.97 - -0.92]), and sex (B -1.28 [95 % CI: -2.5 - -0.07]). The serum iron level of visceral leishmaniasis patients was affected by alcohol (B 7.6 [95 % CI: 5.86 – 9.35]), family size (B -5.14 [95 % CI: -7.01 - -3.28]), malaria (B -12.69 [95 % CI: -14.53 - -10.87]), Hookworm (-4.48 [-6.82 - -2.14]), chronic diseases (B -7.44 [95 % CI: -9.75 - -5.13]), and HIV (B -5.51 [95% CI: -8.23 - -2.78]). The serum selenium level of visceral leishmaniasis patient was affected by HIV (B -18.1 [95 % CI: -20.63 - -15.58]) and family size (B -11.36 [95 % CI: -13.02 - -9.7]). The iodine level of visceral leishmaniasis patient was affected by HIV (B -38.02 [95 % CI: -41.98 - -34.06]), DDS (B 25 .84 [95 % CI: 22.57 – 29.1]), smoking (B -12.34 [95 % CI: -15.98 - -8.7]), chronic illness (B -5.14 [95 % CI: -7.82 - -2.46]), and regular physical exercise (B 5.82 [95 % CI: 0.39 - 11.26]). The serum vitamin D level of visceral leishmaniasis patient was affected by HIV (B -9.43 [95 % CI: -10.92 - -7.94]), DDS (B 16.24 [95% CI: 14.89 – 17.58]), malaria (B -0.61 [95 % CI: -3.37 - -3.37]), and family size (B -1.15 [95 % CI: -2.03 - -0.28]). The serum vitamin A level of visceral leishmaniasis patient was affected by residence (B 0.81 [95 % CI: 0.08 - 1.54]), BMI (B 1.52 [95 % CI: 0.42 – 2.6]), DDS (B 1.62 [95 % CI: 0.36 – 2.88]), family size (B -5.03 [95 % CI: -5.83 - -4.22]), HIV (B -2.89 [95% CI: -4.44 - -1.34]),MUAC (B 0.86 [95 % CI: 0.52 – 1.21]), and age (B 0.09 [95 % CI: 0.07 – 0.12]). Conclusion: The micronutrient levels of visceral leishmaniasis patients were significantly lower. The anti-leishmaniasis treatment did not increase the serum micronutrient level of the patients.

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Section: Discussionsupporting

confidence: 93%

Micronutrient levels and their effect on the prognosis of visceral leishmaniasis treatment; a prospective cohort study.

Feleke

2020

Preprint

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“…Smoking decreases the iodine level of visceral leishmaniasis patients by 12.34mcg/l. This nding agrees with previous scholar's work [65]. This is due to the effect of smoking in disturbing the iodine metabolism by disrupting the normal thyroid gland functions [66,67].…”

Section: Discussionsupporting

confidence: 93%

Micronutrient levels and their effect on the prognosis of visceral leishmaniasis treatment; a prospective cohort study.

Feleke

2020

Preprint

View full text Add to dashboard Cite

Background: Micronutrients are minerals and vitamins required in small amounts, and they are essential for normal physiological activities. The objectives of the study were to describe the progress and determinants of micronutrients level and to assess the effect of micronutrients in the treatment outcomes. Methods: A prospective cohort study was implemented. The data were collected using interviews, measuring anthropometric indicators, collecting blood, urine, and stool samples from each patient. The blood samples were collected five times: before starting anti-leishmaniasis treatments, in the first week, in the second week, in the third week, and in the 4th week of anti-leishmaniasis treatments. Descriptive statistics were used to describe the profile of patients and to compare the treatment success rate of visceral leishmaniasis patients. The generalized estimating equation was used to identify the determinants of serum micronutrients.Results: The serum zinc level of visceral leishmaniasis patients was affected by alcohol, DDS, family size, HIV, and sex. The serum iron level of visceral leishmaniasis patients were affected by alcohol, family size, malaria, hookworm, chronic diseases, and HIV. The serum selenium level of visceral leishmaniasis patients was affected by HIV and family size. The iodine level of visceral leishmaniasis patients was affected by HIV, DDS, smoking, chronic illness, and regular physical exercise. The serum vitamin D level of visceral leishmaniasis patients was affected by HIV, alcohol, chronic illness, DDS, malaria, family size, age, residence, and MUAC. The serum vitamin D level of visceral leishmaniasis patients was affected by BMI, DDS, malaria, hookworm, family size, HIV, and age. Conclusion: The Micronutrient levels of visceral leishmaniasis patients were significantly low. Anti-leishmaniasis treatment did not increase the serum micronutrient levels of the patients.

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“…In recent years, with the increasing number of patients with hypothyroidism in the population, the impact of iodine and uoride on thyroid function has become a hot issue of common concern but the research results are different [7,13,14] [15-21, 38, 39] . This study found that gender and urinary iodine are in uencing factors of TSH increase, which is consistent with the results of studies such as Vanderpump MP [12], Danchen Wang [40], and Wang D [41] Drinking water uoride is a critical in uencing factor. Some studies have found that [6,15,16,42,43] high uoride and high iodine and high uoride are related to elevated serum TSH.…”

Section: Discussionsupporting

confidence: 91%

Construction of a Nomogram Model to Predict The Risk of Hypothyroidism in Patients With Thyroid Nodule Caused by Environmental Iodine and Fluorine

RuiXia¹,

Yang²,

Yan-guo³

et al. 2020

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Background: Patients with thyroid nodules may be complicated by hypothyroidism. However, effective means to predict thyroid-stimulating hormone (TSH) elevation in patients with thyroid nodules are currently lacking. Therefore, the research team recruited some patients with thyroid nodules to explore the relationship between TSH, environmental iodine, and fluoride and the development of thyroid nodules, and to draw a Nomogram in order to provide guidance for predicting hypothyroidism in patients with thyroid nodules.Methods: The subjects were from 313 patients with thyroid nodules in different areas of iodine and fluoride, with 71 men and 242 women. The content of TSH in serum of thyroid nodule patients was determined by electrochemical luminescence method. The iodine content in drinking water and urine was determined by arsenic-cerium catalytic spectrophotometry. Fluoride in drinking water and urine was determined by fluoride ion selective electrode method. Univariate analysis, Lasso regression analysis and multiple factor Logistic regression analysis were used to screen the variables included in the Nomogram model. And the corresponding Nomogram model was constructed. ROC curve was drawn and repeated Bootstrap self-sampling method was used to test model differentiation.Results: There were 53 patients with elevated serum TSH and 256 patients with normal thyroid nodule. Multivariate logistic regression analysis shows that urine iodine（Odds Ratio[OR]=1.001, 95% confidence interval [95%CI]:1.001～1.002, P=0.01） and gender (OR=3.328, 95% CI:1.256～8.819, P=0.079) are independent risk factors raised by serum TSH. And drinking water fluoride（OR=1.990, 95% CI:0.924～4.289, P=0.079）is a critical factor. Based on these risk factors, the predictive model and nomogram of serum TSH elevation in patients with thyroid nodule were constructed. The area under the ROC curve was 0.678 (P<0.001), confirming Nomogram's predictive potential. The calibration diagram of the Nomogram prediction model shows that the predicted values are in good agreement with the observed values.Conclusion: Gender, urine iodine and drinking water fluoride of thyroid nodules are independent influencing factors for the rise of serum TSH. The Nomogram can become a predictive accuracy and differentiation.

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Iodine status of euthyroid adults: A cross‐sectional, multicenter study

Cited by 15 publications

References 15 publications

Micronutrient levels and their effect on the prognosis of visceral leishmaniasis treatment; a prospective cohort study.

Micronutrient levels and their effect on the prognosis of visceral leishmaniasis treatment; a prospective cohort study.

Micronutrient levels and their effect on the prognosis of visceral leishmaniasis treatment; a prospective cohort study.

Construction of a Nomogram Model to Predict The Risk of Hypothyroidism in Patients With Thyroid Nodule Caused by Environmental Iodine and Fluorine

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