Iodine seeds in the treatment of slowly proliferating tumours in the head and neck region

Surgery combined with postoperative 125I seed brachytherapy for the treatment of mucoepidermoid carcinoma of the parotid gland in pediatric patients

“…Postoperative 125 I seed brachytherapy delivers a high dose of radiation directly to the tumor, minimizing nontarget dose dispersal to the adjacent normal structures, and is increasingly being found effective for treating patients with malignant head and neck tumors and improving local control (LC) and patient survival. 12,13 In adult patients with parotid gland malignances, 125 I seed brachytherapy has been proved effective with minor radiation-associated side effects. [14][15][16][17] To determine the long-term outcomes and associated complications among pediatric patients with MEC of the parotid gland treated with a combination of surgery and postoperative 125 I seed brachytherapy, we retrospectively reviewed patient data from Peking University School and Hospital of Stomatology.…”

Postoperative iodine‐125 interstitial brachytherapy for the early stages of minor salivary gland carcinomas of the lip and buccal mucosa with positive or close margins

“…Local control rates can reach 90% to 95% at 5 years for early stages of lip squamous cell carcinomas treated by low‐dose‐rate brachytherapy and 80% to 90% for buccal mucosa carcinomas . The half‐life period of 125 I is 59.4 days, which is classified as low‐dose‐rate brachytherapy, exhibiting a favorable efficacy to slowly proliferating tumors . The application of permanent 125 I seed interstitial brachytherapy for recurrent or locally advanced salivary gland carcinomas showed satisfactory efficacy .…”

“…24 The half-life period of 125 I is 59.4 days, which is classified as low-dose-rate brachytherapy, exhibiting a favorable efficacy to slowly proliferating tumors. 25,26 The application of permanent 125 I seed interstitial brachytherapy for recurrent or locally advanced salivary gland carcinomas showed satisfactory efficacy. 27,28 According to Zhang et al, 29 surgery that preserved the facial nerves plus postoperative 125 I seed interstitial brachytherapy was successful in the treatment of parotid gland carcinomas and improving the subsequent quality of life in 12 patients.…”

Postoperative 125I brachytherapy delivered by digital model obturators for recurrent or locally advanced maxillary cancers

“…Brachytherapy can deliver a high radiation dose to a tumor while sparing surrounding normal vital tissues 20, 21. The low dose rate of 125 I irradiation can enhance the tolerance of normal tissues 22. Several reports have analyzed the benefits of 125 I brachytherapy used alone or combined with surgery for head and neck cancers 21–25…”