Iodine prophylaxis—the protective factor against stomach cancer in iodine deficient areas

Gołkowski, Filip; Szybiński, Z; Rachtan, Jadwiga; Sokołowski, Andrzej; Buziak-Bereza, Monika; Trofimiuk, Małgorzata; Hubalewska‐Dydejczyk, Alicja; Przybylik-Mazurek, Elwira; Huszno, Bohdan

doi:10.1007/s00394-007-0657-8

Cited by 34 publications

(21 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The risk of stomach cancer is increased significantly by cigarette smoking (40% in smokers, and by 82% in heavy smokers) and alcohol intake (IARC, 2004). Some researchers have pointed out the correlation between lack or excess of iodine, goiter and stomach cancer, and reduced mortality from the stomach cancer following effective iodine prophylaxis (Gołkowski et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Mortality from Stomach Cancer in Serbia, Excluding the Province of Kosovo, in the 1991-2009 Period

Ilić

Prodović²,

Milosavljević³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Mortality from Stomach Cancer in Serbia, Excluding the Province of Kosovo, in the 1991-2009 Period

Ilić

Prodović²,

Milosavljević³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…The thyroid gland and stomach, despite the different localization and function, share some similar morphologic and functional characteristics, likely due to their common embryologic origin (11). In fact, the thyroid gland develops from the primitive gut and therefore thyroid follicular share with parietal cells the same endodermal origin.…”

Section: Thyroid and Stomach: Embryologic Derivation And Role Of Na+/mentioning

confidence: 99%

“…This notion is supported by the high percentage (12–40%) of positivity of PCA in adult patients with HT (9) which, in turn, is present in approximately 40% of patients with atrophic gastritis (10). Besides the fact that the thyroid and the stomach share some embryological and biochemical features (11), some intriguing similarities have been observed even in the putative pathogenic mechanisms, which characterize the thyrogastric syndrome (12). Furthermore, some specific clinical features characterize or lead to the suspicion of the coexistence of both thyroid and gastric autoimmune (13, 14) disorders.…”

Section: Introductionmentioning

confidence: 99%

Hashimoto’s Thyroiditis and Autoimmune Gastritis

Cellini¹,

Santaguida²,

Virili³

et al. 2017

Front. Endocrinol.

View full text Add to dashboard Cite

The term “thyrogastric syndrome” defines the association between autoimmune thyroid disease and chronic autoimmune gastritis (CAG), and it was first described in the early 1960s. More recently, this association has been included in polyglandular autoimmune syndrome type IIIb, in which autoimmune thyroiditis represents the pivotal disorder. Hashimoto’s thyroiditis (HT) is the most frequent autoimmune disease, and it has been reported to be associated with gastric disorders in 10–40% of patients while about 40% of patients with autoimmune gastritis also present HT. Some intriguing similarities have been described about the pathogenic mechanism of these two disorders, involving a complex interaction among genetic, embryological, immunologic, and environmental factors. CAG is characterized by a partial or total disappearance of parietal cells implying the impairment of both hydrochloric acid and intrinsic factor production. The clinical outcome of this gastric damage is the occurrence of a hypochlorhydric-dependent iron-deficient anemia, followed by pernicious anemia concomitant with the progression to a severe gastric atrophy. Malabsorption of levothyroxine may occur as well. We have briefly summarized in this minireview the most recent achievements on this peculiar association of diseases that, in the last years, have been increasingly diagnosed.

show abstract

“…The reference electrode was Ag/AgCl saturated KCl, the counter electrode was a platinum wire and the working electrode was BDD. The working geometric area was 0.126 cm 2 . The electrochemical oxidation of I 2 , KI and KIO 3 was performed in 1 M NaClO 4 .…”

Section: Electrochemical Measurementsmentioning

confidence: 99%

“…Deficiency of iodine can lead to mental retardation, endemic goiter and could be a possible cause of stomach cancer [1,2]. In women, such deficiency can lead to overt hypothyroidism and consequent anovulation, infertility, gestational hypertension, spontaneous first-trimester abortion and stillbirth [3].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous detection of iodine and iodide on boron doped diamond electrodes

Fierro

Comninellis

Einaga

2013

Talanta

View full text Add to dashboard Cite

a b s t r a c tIndividual and simultaneous electrochemical detection of iodide and iodine has been performed via cyclic voltammetry on boron doped diamond (BDD) electrodes in a 1 M NaClO 4 (pH 8) solution, representative of typical environmental water conditions. It is feasible to compute accurate calibration curve for both compounds using cyclic voltammetry measurements by determining the peak current intensities as a function of the concentration. A lower detection limit of about 20 mM was obtained for iodide and 10 mM for iodine. Based on the comparison between the peak current intensities reported during the oxidation of KI, it is probable that iodide (I À ) is first oxidized in a single step to yield iodine (I 2 ). The latter is further oxidized to obtain IO 3 À . This technique, however, did not allow for a reasonably accurate detection of iodate (IO 3 À ) on a BDD electrode.

show abstract

Iodine prophylaxis—the protective factor against stomach cancer in iodine deficient areas

Abstract: Observed association between improved iodine supply and decrease of incidence of stomach cancer could indicate the protective role against stomach cancer of iodine prophylaxis in iodine deficient areas--further studies are necessary.

Cited by 34 publications

References 13 publications

Mortality from Stomach Cancer in Serbia, Excluding the Province of Kosovo, in the 1991-2009 Period

Mortality from Stomach Cancer in Serbia, Excluding the Province of Kosovo, in the 1991-2009 Period

Hashimoto’s Thyroiditis and Autoimmune Gastritis

Simultaneous detection of iodine and iodide on boron doped diamond electrodes

Contact Info

Product

Resources

About