Abstract:Objectives: Papillary thyroid carcinoma (PTC) accounts for approximately 85%-90% of all thyroid cancers. Of the iodine-metabolizing genes, BRAFV600E is a highly specific target for PTC and may have a reciprocal causative relationship with iodide-metabolizing genes. Materials and methods: In this study, we performed a data analysis of selected quantitative studies to determine the relationship between iodine nutritional status and the prevalence of the BRAF600E mutation in patients with PTC. Five studies were s… Show more
“…A Korean study found that both relatively excessive iodine intake and low iodine intake appear to be important risk factors for BRAF mutations in PTC patients [ 24 ]. A recent Meta-Analysis study found that the incidence of BRAF V600E mutations in PTC patients with high iodine intake was 77.6%, which was higher than 64.61% in patients with low iodine intake and 60.15% in patients with normal iodine intake [ 7 ]. Despite a considerable body of research on the impact of iodine on thyroid cancer tumorigenesis and progression, the association involving high iodine intake and TC risk remains contentious, and the mechanisms behind iodine excess in the development of PTC are still unclear [ 25 – 34 ].…”
Section: Discussionmentioning
confidence: 99%
“…Iodine intake may induce BRAF V600E gene mutations in PTC patients through various indirect pathways [ 7 ]. However, the effect of BRAF V600E gene mutation on the circ-0004851/miR-296-3p/FGF11 pathway is unknown.…”
Section: Discussionmentioning
confidence: 99%
“…The above findings suggest that miR-296-3p may indirectly regulate the level of HIF1α by targeting and regulating its downstream genes. Iodine intake may induce BRAF V600E gene mutations in PTC patients through various indirect pathways [7]. However, the effect of BRAF V600E gene mutation on the circ-0004851/miR-296-3p/FGF11 pathway is unknown.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, the BRAF V600E gene mutation is the most common genetic mutation in PTC, with an average incidence of about 45% [ 6 ]. Interestingly, previous studies have concluded that among the iodine metabolism genes, BRAF V600E is a highly specific target for PTC [ 7 ]. Nonetheless, the impact of high iodine levels on existing thyroid cancer and its underlying mechanisms warrant further investigation.…”
The prevalence of papillary thyroid cancer (PTC) has been rising in recent years. Despite its relatively low mortality, PTC frequently metastasizes to lymph nodes and often recurs, posing significant health and economic burdens. The role of iodine in the pathogenesis and advancement of thyroid cancer remains poorly understood. Circular RNAs (circRNAs) are recognized to function as competing endogenous RNAs (ceRNAs) that modulate gene expression and play a role in various cancer stages. Consequently, this research aimed to elucidate the mechanism by which circRNA influences the impact of iodine on PTC. Our research indicates that high iodine levels can exacerbate the malignancy of PTC via the circ_0004851/miR-296-3p/FGF11 axis. These insights into iodine’s biological role in PTC and the association of circRNA with the disease could pave the way for novel biomarkers and potentially effective therapeutic strategies to mitigate PTC progression.
“…A Korean study found that both relatively excessive iodine intake and low iodine intake appear to be important risk factors for BRAF mutations in PTC patients [ 24 ]. A recent Meta-Analysis study found that the incidence of BRAF V600E mutations in PTC patients with high iodine intake was 77.6%, which was higher than 64.61% in patients with low iodine intake and 60.15% in patients with normal iodine intake [ 7 ]. Despite a considerable body of research on the impact of iodine on thyroid cancer tumorigenesis and progression, the association involving high iodine intake and TC risk remains contentious, and the mechanisms behind iodine excess in the development of PTC are still unclear [ 25 – 34 ].…”
Section: Discussionmentioning
confidence: 99%
“…Iodine intake may induce BRAF V600E gene mutations in PTC patients through various indirect pathways [ 7 ]. However, the effect of BRAF V600E gene mutation on the circ-0004851/miR-296-3p/FGF11 pathway is unknown.…”
Section: Discussionmentioning
confidence: 99%
“…The above findings suggest that miR-296-3p may indirectly regulate the level of HIF1α by targeting and regulating its downstream genes. Iodine intake may induce BRAF V600E gene mutations in PTC patients through various indirect pathways [7]. However, the effect of BRAF V600E gene mutation on the circ-0004851/miR-296-3p/FGF11 pathway is unknown.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, the BRAF V600E gene mutation is the most common genetic mutation in PTC, with an average incidence of about 45% [ 6 ]. Interestingly, previous studies have concluded that among the iodine metabolism genes, BRAF V600E is a highly specific target for PTC [ 7 ]. Nonetheless, the impact of high iodine levels on existing thyroid cancer and its underlying mechanisms warrant further investigation.…”
The prevalence of papillary thyroid cancer (PTC) has been rising in recent years. Despite its relatively low mortality, PTC frequently metastasizes to lymph nodes and often recurs, posing significant health and economic burdens. The role of iodine in the pathogenesis and advancement of thyroid cancer remains poorly understood. Circular RNAs (circRNAs) are recognized to function as competing endogenous RNAs (ceRNAs) that modulate gene expression and play a role in various cancer stages. Consequently, this research aimed to elucidate the mechanism by which circRNA influences the impact of iodine on PTC. Our research indicates that high iodine levels can exacerbate the malignancy of PTC via the circ_0004851/miR-296-3p/FGF11 axis. These insights into iodine’s biological role in PTC and the association of circRNA with the disease could pave the way for novel biomarkers and potentially effective therapeutic strategies to mitigate PTC progression.
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