Iodine Mediated Oxidative Cross-Coupling of Benzo[ d ]Imidazo[2,1- b ]Thiazoles with Ethylbenzene: An Unprecedented Approach of C3-Dicarbonylation

Iodine and DMSO as Surrogate of Hazardous Metal and Non‐Metal Reagents in Organic Synthesis

“…[621] Iodine and DMSO have also been used to achieve the same goal with phenylbenzoimidazothiazole and ethylbenzene as precursors (Scheme 60 (c)). [622] The latter method yielded 78 % product using 0.2 equivalent of molecular iodine and TBHP in a 3 : 1 solvent mixture with DMSO. The absence of TBHP decreased the yield to 22 %, and the absence of iodine resulted in no product formation.…”

“…Later in 2017, Shaik and group used iodine and DMSO as reagent combination to achieve the desired products starting from styrene and phenylbenzoimidazothiazole (Scheme 60 (b)) [621] . Iodine and DMSO have also been used to achieve the same goal with phenylbenzoimidazothiazole and ethylbenzene as precursors (Scheme 60 (c)) [622] . The latter method yielded 78 % product using 0.2 equivalent of molecular iodine and TBHP in a 3 : 1 solvent mixture with DMSO.…”