Iodine intake as a risk factor for BRAF mutations in papillary thyroid cancer patients from an iodine-replete area

Kim, Hye Jeong; Park, Hyeong Kyu; Byun, Dong Won; Suh, Kyoil; Yoo, Myung Hi; Min, Yong‐Ki; Kim, Sun Wook; Chung, Jae Hoon

doi:10.1007/s00394-016-1370-2

Cited by 44 publications

(49 citation statements)

References 25 publications

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“…Our finding is similar to those reported in PTC patients diagnosed in cities from other Brazilian regions, such as Goiânia (74/116; 63,8%) and Porto Alegre (19/32; 59,4%) (19,20). Some studies have implied that the increased occurrence of BRAF (V600E) mutation in PTC may be associated with high dietary iodine intake (21). We found in a previous study from our laboratory a high risk of excessive nutritional iodine intake among schoolchildren in Salvador (22), a coastal Brazilian city.…”

Section: Discussionsupporting

confidence: 89%

Association between BRAF (V600E) mutation and clinicopathological features of papillary thyroid carcinoma: a Brazilian single-centre case series

Pessôa‐Pereira¹,

Medeiros²,

Lima³

et al. 2019

Archives of Endocrinology and Metabolism

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Objectives: We aimed to investigate the prevalence of the BRAF (V600E) mutation in consecutive cases of papillary thyroid carcinoma (PTC) in patients diagnosed and treated at the Hospital Sao Rafael (Salvador, BA, Brazil) and evaluate its association with clinical and pathological characteristics of PTC. Subjects and methods: We retrospectively enrolled in the study a total of 43 consecutive PTC patients who underwent total thyroidectomy. We performed DNA extraction from formalinfixed paraffin-embedded (FFPE) tumour tissue samples. Polymerase chain reaction (PCR) and direct sequencing were used to determine BRAF (V600E) mutation status. Univariate and multivariate logistic regression analyses were employed to identify independent associations. Results: The prevalence of BRAF (V600E) mutation was 65.1% (28/43). A high frequency of older patients (p value: 0.004) was observed among the BRAF-mutated PTC group and, in contrast, a low frequency of concurrent Hashimoto's thyroiditis (HT) (p value: 0.011) was noted. Multivariate analysis confirmed that older age (OR: 1.15; 95% CI: 1.00-1.33; p value: 0.047) and HT (OR: 0.05; 95% CI: 0.006-0.40; p value: 0.005) were independent factors associated with BRAF (V600E) mutation. Conclusion: We found a high prevalence of BRAF (V600E) mutation in PTC cases. Older age and no concurrent HT were independently associated with BRAF (V600E) mutation.

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Section: Discussionsupporting

confidence: 89%

Association between BRAF (V600E) mutation and clinicopathological features of papillary thyroid carcinoma: a Brazilian single-centre case series

Pessôa‐Pereira¹,

Medeiros²,

Lima³

et al. 2019

Archives of Endocrinology and Metabolism

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“…In contrast, in a Korean population that chronically consumes iodine-rich foods, Kim et al demonstrated that BRAF mutations in PTC were more frequent in subjects with either low (urinary iodine concentration, UIC < 300 µg/L) or excessive iodine intakes (UIC ≥ 500 µg/L) [26]. …”

Section: Eating Habitsmentioning

confidence: 99%

Nutritional and Environmental Factors in Thyroid Carcinogenesis

Nettore

Colao

Macchia

2018

IJERPH

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Several epidemiological studies suggest an increased incidence of thyroid carcinoma (TC) in recent years, especially for the papillary histotype (PTC), suggesting that specific carcinogens might promote molecular abnormalities that are typical of PTC. The increased incidence is probably attributed to more intensive and sensitive diagnostic procedures, even if recent data suggest that various toxic elements could explain the phenomenon. Ionizing radiation exposure represents the most accepted risk factor for differentiated thyroid cancer that includes both the follicular and papillary histotypes. In this review, we examined the other environmental carcinogens that play a role in TC, such as eating habits, living in volcanic areas, and xenobiotic elements. Among eating habits, iodine intake represents one of the more discussed elements, because its deficiency is associated with follicular thyroid carcinomas (FTCs), while its progressive increment seems to be responsible for PTC. The gas, ash, and lava emissions of volcanoes are composed of various toxic compounds that pollute ground water, vegetables, and animals, contaminating humans via the food chain. Finally, the risk of developing PTC has also been associated with exposure of the population to xenobiotics in the environment or in the home. Their carcinogenic effects are probably caused by their accumulation, but additional studies are necessary to better understand the mechanisms of action.

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“…Так, дефіцит йоду може призводити до превалювання фолікулярного типу РЩЗ, а при проведені йодної профілактики, навпаки -папілярної, про що свідчать дослідження Dong W. et al (2013) та Kim H.J. et al (2017) [91,92]. Пов'язаний з йодом зсув від фолікулярного до папілярного гістологічного типу може бути зумовлений частотою мутації BRAF (V600E) [92].…”

Section: в п о м о щ ь п р а к т и ч е с к о м у в р а ч уunclassified

“…et al (2017) [91,92]. Пов'язаний з йодом зсув від фолікулярного до папілярного гістологічного типу може бути зумовлений частотою мутації BRAF (V600E) [92]. Один з недавніх мета-аналізів, проведений Cao L.Z.…”

Section: в п о м о щ ь п р а к т и ч е с к о м у в р а ч уunclassified

Modern view on the risk factors for malignant tumors of the thyroid gland: a systematic review

Ткаченко

Рімар

2018

FMEP

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The morbidity of thyroid carcinoma (TC) tends to annual growth. The results of the multifactorial studies of the development of thyroid carcinogenesis testify the insufficient knowledge about the influence and significance of certain TC factors, which requires systematization in order to improve the oncoepidemic situation in the country.The objective: of this study was to conduct an analytical systematic review of literature to resume risk factors of TC in the last 10 years.Materials and methods. The generalization of literary sources, founded by key words in Google Scholar, PubMed and eLIBRARY.ru for 2007 to 2017 was carried out. We analyzed the value of the odds ratio (OR), the relative risk (RR), the hazard ratio (HR), standardized incidence ratio (SIR) and an excess relative risk (ERR) with respective confidence intervals (95% CI), as well as the reliability value (p).Results. The most significant risk factors for TC are: ionizing radiation (increases the incidence in 1,3–5 times); previous thyroid disease (associated with TC in 30–94% cases, most goiter, adenoma and AIT – in 29,7%, OR=2,12; RR=1,4), heredity (presence of TC in I degree relatives increases the chance of occurrence in > 4-times), systemic autoimmune disease (SLE increases the risk 1,8 times), diabetes (TC risk increases on 18–20%), menstrual and reproductive factors (increased risk in 1,2–2,4 times), anthropometric factors (high height – increases the risk in 1,2–1,6 times, BMI ≥30 kg/m2 – in 1,35–1,7 times, and the waist >90 cm in women – in 1,3 times); benign breast disease (TC risk is higher on 38–56%), breast cancer (TC risk increases in 1,4–2,3 times), deficiency of vitamin D (TC risk increases 2–6 times), the persistence of virus, insufficient iodine intake, lifestyle – the use of certain products and physical activity, anthropogenic and occupational factors.Conclusion. The primary care physician should take into account the current understanding of the risk ТС factors in patients, especially in high-risk groups.

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Iodine intake as a risk factor for BRAF mutations in papillary thyroid cancer patients from an iodine-replete area

Abstract: Relatively low iodine intake and more than excessive iodine intake seem to be significant risk factors for the occurrence of BRAF mutations in the thyroid and, therefore, may be risk factors for the development of PTC in an iodine-replete area.

Cited by 44 publications

References 25 publications

Association between BRAF (V600E) mutation and clinicopathological features of papillary thyroid carcinoma: a Brazilian single-centre case series

Association between BRAF (V600E) mutation and clinicopathological features of papillary thyroid carcinoma: a Brazilian single-centre case series

Nutritional and Environmental Factors in Thyroid Carcinogenesis

Modern view on the risk factors for malignant tumors of the thyroid gland: a systematic review

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