Iodine-Induced Hypothyroidism in Full-term Infants With Congenital Heart Disease: More Common Than Currently Appreciated?

Thaker, Vidhu; Leung, Angela M.; Braverman, Lewis E.; Brown, Rosalind S.; Levine, Bat-Sheva

doi:10.1210/jc.2014-1956

Cited by 46 publications

(36 citation statements)

References 27 publications

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“…This can occur especially in premature babies (28,29) and in term infants with congenital heart disease needing cardiac catheterization (30,31). Preterm infants get exposed high doses of iodine with usage of iodine containing antiseptics for umbilical and peripherally inserted central catheter (PICC) lines.…”

Section: Neonatal Iodine Exposurementioning

confidence: 99%

Transient hypothyroidism in the newborn: to treat or not to treat

Kanike¹,

Davis²,

Shekhawat³

2017

Transl. Pediatr

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Section: Neonatal Iodine Exposurementioning

confidence: 99%

Transient hypothyroidism in the newborn: to treat or not to treat

Kanike¹,

Davis²,

Shekhawat³

2017

Transl. Pediatr

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“…Infants may be particularly vulnerable to iodine deficiency and iodine excess as the fetal and newborn thyroid has limited iodine stores and adapts poorly to high intakes (3,4,5). Acute iodine excess from for example maternal iodine supplements and iodine containing skin disinfectants may cause hypothyroidism in newborns (6,7). Recent data indicate that older infants may be able to adapt to high iodine intakes and maintain their euthyroid state (8).…”

Section: Introductionmentioning

confidence: 99%

Breast-Milk Iodine Concentrations, Iodine Status, and Thyroid Function of Breastfed Infants Aged 2-4 Months and Their Mothers Residing in a South African Township

Osei

Andersson²,

Reijden³

et al. 2016

Jcrpe

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Objective:Lactating women and their infants are susceptible to iodine deficiency and iodine excess. In South Africa, no data exist on the iodine status and thyroid function of these vulnerable groups.Methods:In a cross-sectional study, urinary iodine concentrations (UIC), thyroid function, and breast-milk iodine concentrations (BMIC) were assessed in 100 lactating women from a South African township and their 2-4-month-old breastfed infants. Potential predictors of UIC, thyroid function, and BMIC, including household salt iodine concentrations (SIC) and maternal sodium excretion, were also investigated.Results:The median (25th-75th percentile) UIC was 373 (202-627) μg/L in infants and 118 (67-179) μg/L in mothers. Median household SIC was 44 (27-63) ppm. Household SIC and maternal urinary sodium excretion predicted UIC of lactating mothers. Median BMIC was 179 (126-269) μg/L. Age of infants, SIC, and maternal UIC predicted BMIC. In turn, infant age and BMIC predicted UIC of infants. Forty-two percent of SIC values were within the South African recommended salt iodine fortification level at production of 35-65 ppm, whilst 21% of SIC were >65 ppm. Thyroid-stimulating hormone, total thyroxine, and thyroglobulin concentrations in the dried whole blood spot specimens from the infants were 1.3 (0.8-1.9) mU/L, 128±33 mmol/L, and 77.1 (56.3-105.7) μg/L, respectively, and did not correlate with infant UIC or BMIC.Conclusion:Our results suggest that the salt fortification program in South Africa provides adequate iodine to lactating women and indirectly to their infants via breast milk. However, monitoring of salt iodine content of the mandatory salt iodization program in South Africa is important to avoid over-iodization of salt.

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“…15 Furthermore, iodine in topical antiseptic agents and contrast media can affect thyroid function of preterm neonates. 16 In our NICU, iodine antiseptic agent has not been used for many years, so any effect of topical iodine antiseptic agents could be ruled out. Additionally, those medications that might affect thyroid function were not administered to the three twins.…”

Section: ) Twin Amentioning

confidence: 98%

“…They did not have any history of RDS, NEC, or IVH. There was no history of dopamine, glucocorticoid, furosemide, phenobarbital, insulin, and vancomycin administration.Both infants started breastfeeding before the initial screening.There was not much difference in breastmilk ingestion until the initial TFT between siblings (infants C-1 and C-2, 15.4 vs 16…”

mentioning

confidence: 91%

Thyroid Function of Preterm Twins Having Breastmilk from Their Mothers Consuming Seaweed Soup Might Be Variable between Siblings: A Case Series

et al. 2020

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Thyroid dysfunction is common in preterm infants. Breastmilk-fed (BMF) preterm infants in Korea often develop hypothyroidism because of excessive maternal iodine ingestion. Recently in our neonatal intensive care unit, we encountered three pairs of BMF preterm twins showing discrepancies in thyroid function at 1 month of age. Their mothers consumed seaweed soup daily during that time. Within each BMF pair, the amount of breastmilk intake was almost similar. However, thyroid function differed within twins. Urinary iodine concentrations were different within twins and not correlated with thyroid dysfunction. The clinical characteristics within each pair were not significantly different.In conclusion, thyroid function would be different even between BMF premature twin siblings despite the same amount of iodine intake and the similar conditions that are currently known to affect thyroid function. Therefore, serial evaluation of thyroid function in BMF preterm infants would be crucial.

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Iodine-Induced Hypothyroidism in Full-term Infants With Congenital Heart Disease: More Common Than Currently Appreciated?

Cited by 46 publications

References 27 publications

Transient hypothyroidism in the newborn: to treat or not to treat

Transient hypothyroidism in the newborn: to treat or not to treat

Breast-Milk Iodine Concentrations, Iodine Status, and Thyroid Function of Breastfed Infants Aged 2-4 Months and Their Mothers Residing in a South African Township

Thyroid Function of Preterm Twins Having Breastmilk from Their Mothers Consuming Seaweed Soup Might Be Variable between Siblings: A Case Series

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